Skin quality treatments by injecting uncrosslinked hyaluronic acid (HA) are widely used in aesthetic medicine. The proven biological effect of native high molecular weight HA contributes to moisturize, improve skin color and texture, as well as restore its density by stimulating neocollagenesis. HA-based injectables have a proven profile of efficacy and safety. They are biocompatible with human tissues; therefore, they are actively used in programs of age-related changes treatment. The biorevitalization treatment is intradermal injection of HA in order to replenish the lost reserve of glycosaminoglycans and restore natural conditions for cell's functioning. The treatment result is the activation of the autoregulation mechanism of the synthesis of endogenous HA and other components of the dermal intercellular. Biorevitalization provides improvement of elasticity and turgor of tissues, rehydration and increase the antioxidant potential of skin. There are numerous cosmetic preparations, injectables and energy-based methods designed to treat involutional skin changes. The comprehensive approach involves the possibility of combining biorevitalization treatment with peelings, HA fillers, polylactic acid (PLLA), botulinum toxin, high-intensity focused ultrasound (HIFU), lasers and thread lift. The inclusion of biorevitalization in combined programs contributes to the optimization of aesthetic effect due to the multiple components and synergy of action mechanism. The use of combined effects contributes to favorable clinical results and high patients' satisfaction with their general appearance.