The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Lopatin A.S.

Polyclinic No.1 President’s Affairs Management of the Russian Federation

Azizov I.S.

Smolensk State Medical University

Kozlov R.S.

Smolensk State Medical University

Microbiome of nasal cavity and paranasal sinuses in norm and pathology. Part II

Authors:

Lopatin A.S., Azizov I.S., Kozlov R.S.

More about the authors

Journal: Russian Rhinology. 2021;29(2): 81‑89

DOI: 10.17116/rosrino20212902181

Read: 12595 times

Download PDF (RU)
Contact the author
Table of contents

MICROBIOME OF NASAL CAVITY AND PARANASAL SINUSES IN NORM AND PATHOLOGY. PART II
MICROBIOME OF NASAL CAVITY AND PARANASAL SINUSES IN NORM AND PATHOLOGY. PART II

To cite this article:

Lopatin AS, Azizov IS, Kozlov RS. Microbiome of nasal cavity and paranasal sinuses in norm and pathology. Part II. Russian Rhinology. 2021;29(2):81‑89. (In Russ.)
https://doi.org/10.17116/rosrino20212902181

Подписка 2026 Российская ринология (Russian Rhinology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Morphological features of repa­rative rege­neration in inflammatory response of the nasal mucosa after injury: an expe­rimental study. Russian Rhinology. 2024;(4):254-261
A Randomized Controlled Trial Comparing Bude­sonide and Mome­tasone Furoate Nasal Spray in the Treatment of Chro­nic Rhinosinusitis with Nasal Poly­posis: Evaluating Symptom Scores and Quality of Life. Russian Rhinology. 2025;(1):12-17
Foreign body of ethmoidal air cells. Russian Rhinology. 2025;(1):72-75
On the issue of the etiology of acute inflammatory pathology of the pharynx in children. Russian Bulletin of Otorhinolaryngology. 2024;(5):10-15
Preoperative protective preparation of the nasal mucosa of rhinological patients. Russian Bulletin of Otorhinolaryngology. 2024;(5):23-28
Proton pump inhi­bitors: posi­tive and nega­tive properties. On the 45th anni­versary of their discovery. Russian Journal of Preventive Medi­cine. 2024;(11):135-140
Gut microbiota: role in human health and pote­ntial for personalized medi­cine. Russian Journal of Evidence-Based Gastroenterology. 2024;(4):81-88
The gut microbiota in bipo­lar diso­rder. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):28-33
Nutrition correction in the complex therapy and reha­bilitation of the posttraumatic stress diso­rder. Russian Journal of Preventive Medi­cine. 2025;(2):114-119
Diagnostic significance of the gut microbiota and its meta­bolites in cardiovascular risk asse­ssment among patients with ulce­rative coli­tis. Russian Journal of Evidence-Based Gastroenterology. 2025;(1):39-46
Abstract:

The number of publications on the microbiome of the paranasal sinuses (PNS) in norm and pathology has been growing rapidly recent years. Despite the contradictory and difficult to generalize results the studies conducted generally indicate the synonasal microbiome (SNM) in patients with chronic rhinosinusitis (CRS) differs significantly in healthy individuals due to a decrease in biodiversity. Some drugs, primarily antibiotics, have a negative effect on SNM and contribute to the persistence of bacterial inflammation in the SNP. Correction of dysbiotic changes in SNM with the help of systemic or topical probiotics seems to be a promising direction; however, at present, the lack of evidence base does not allow recommending their use in the treatment of CRS.

Keywords:

microbiome
microbiota
nasal cavity
paranasal sinuses
whole genome sequencing
chronic rhinosinusitis
antibiotics
probiotics

Authors:

Lopatin A.S.

Polyclinic No.1 President’s Affairs Management of the Russian Federation

Azizov I.S.

Smolensk State Medical University

Kozlov R.S.

Smolensk State Medical University

Received:

23.08.2020

Accepted:

16.09.2020

Close metadata

References:

  1. Ipci K, Altintoprak N., Bayar Muluk N, Senturk M, Cingi C. The possible mechanisms of the human microbiome in allergic diseases. European Archives of Oto-Rhino-Laryngology. 2017;274(2):617-626.  https://doi.org/10.1007/s00405-016-4058-6
  2. Bell JS, Spencer JI, Yates RL, Yee SA, Jacobs BM, DeLuca GC. Invited review: From nose to gut — the role of the microbiome in neurological disease. Neuropathology and Applied Neurobiology. 2019;45(3):195-215.  https://doi.org/10.1111/nan.12520
  3. de Steenhuijsen Piters WAA, Sanders EAM, Bogaert D. The role of the local microbial ecosystem in respiratory health and disease. Philosophical Transactions of the Royal Society B: Biological Sciences. 2015;370:20140294. https://doi.org/10.1098/rstb.2014.0294
  4. Choi CH, Poroyko V, Watanabe S, Jiang D, Lane J, deTineo M, Baroody F, Naclerio RM, Pinto JM. Seasonal allergic rhinitis affects sinonasal microbiota. American Journal of Rhinology. 2014;28:281-286.  https://doi.org/10.2500/ajra.2014.28.4050
  5. Lal D, Keim P, Delisle J, Barker B, Rank MA, Chia N, Schupp JM, Gillece JD, Cope EK. Mapping and comparing bacterial microbiota in the sinonasal cavity of healthy, allergic rhinitis, and chronic rhinosinusitis subjects. International Forum of Allergy & Rhinology. 2017;7:561-569.  https://doi.org/10.1002/alr.21934
  6. Ramakrishnan VR, Feazel LM, Gitomer SA, Robertson CE, Frank DN. The microbiome of the middle meatus in healthy adults. PLoS One. 2013;8:1-10.  https://doi.org/10.1371/journal.pone.0085507
  7. Charlson ES, Chen J, Custers-Allen R, Bittinger K, Li H, Sinha R, Hwang J, Bushman FD, Collman RG. Disordered microbial communities in the upper respiratory tract of cigarette smokers. PLoS One. 2010;5:1-10.  https://doi.org/10.1371/journal.pone.0015216
  8. Brook I, Gober AE. Effect of smoking cessation on the microbial flora. Archives of Otolaryngology — Head & Neck Surgery. 2007;133:135-138.  https://doi.org/10.1001/archotol.133.2.135
  9. Koskinen K, Reichert JL, Hoier S, Schachenreiter J, Duller S, Moissl-Eichinger C, Schöpf V. The nasal microbiome mirrors and potentially shapes olfactory function. Scientific Reports. 2018;8:1-11.  https://doi.org/10.1038/s41598-018-19438-3
  10. Cook HE, Haber JJ. Bacteriology of the maxillary sinus. Oral & Maxillofacial Surgery. 1987;45:1011-1014. https://doi.org/10.1016/0278-2391(87)90155-8
  11. Abou-Hamad W, Matar N, Elias M, Nasr M, Sarkis-Karam D, Hokayem N, Haddad A. Bacterial flora in normal adult maxillary sinuses. American Journal of Rhinology & Allergy. 2009;23:261-263.  https://doi.org/10.2500/ajra.2009.23.3317
  12. Thanasumpun T, Batra PS. Endoscopically-derived bacterial cultures in chronic rhinosinusitis: A systematic review. American Journal of Otolaryngology. 2015;36:686-691.  https://doi.org/10.1016/j.amjoto.2015.04.010
  13. Zhang Z, Adappa ND, Lautenbach E, Chiu AG, Doghramji LJ, Cohen NA, Palmer JN. Coagulase-negative Staphylococcus culture in chronic rhinosinusitis. International Forum of Allergy & Rhinology. 2015;5:204-213.  https://doi.org/10.1002/alr.21439
  14. Liu CM, Soldanova K, Nordstrom L, Dwan MG, Moss OL, Contente-Cuomo TL, Keim P, Price LB, Lane AP. Medical therapy reduces microbiota diversity and evenness in surgically recalcitrant chronic rhinosinusitis. International Forum of Allergy & Rhinology. 2013;3:775-781.  https://doi.org/10.1002/alr.21195
  15. Hoggard M, Biswas K, Zoing M, Wagner Mackenzie B, Taylor MW, Douglas RG. Evidence of microbiota dysbiosis in chronic rhinosinusitis. International Forum of Allergy & Rhinology. 2017;7:230-239.  https://doi.org/10.1002/alr.21871
  16. Bassiouni A, Paramasivan S, Shiffer A, Dillon MR, Cope EK, Cooksley C, Ramezanpour M, Moraitis S, Ali MJ, Bleier BS, Callejas C, Cornet ME, Douglas RG, Dutra D, Georgalas C, Harvey RJ, Hwang PH, Luong AU, Schlosser RJ, Tantilipikorn P, Tewfik MA, Vreugde S, Wormald PJ, Caporaso JG, Psaltis AJ. Microbiotyping the sinonasal microbiome. Frontiers in Cellular and Infection Microbiology. 2020;10:137.  https://doi.org/10.3389/fcimb.2020.00137
  17. Hoggard M, Waldvogel-Thurlow S, Zoing M, Chang K, Radcliff FJ, Wagner Mackenzie B, Biswas K, Douglas RG, Taylor MW. Inflammatory endotypes and microbial associations in chronic rhinosinusitis. Frontiers in Immunology. 2018;9:2065. https://doi.org/10.3389/fimmu.2018.02065
  18. Wagner Mackenzie B, Waite DW, Hoggard M, Douglas RG, Taylor MW, Biswas K. Bacterial community collapse: a meta-analysis of the sinonasal microbiota in chronic rhinosinusitis. Environmental Microbiology. 2017;19:381-392.  https://doi.org/10.1111/1462-2920.13632
  19. Choi E-B, Hong S-W, Kim D-K, Jeon S-G, Kim K-R, Cho S-H, Gho YS, Jee YK, Kim YK. Decreased diversity of nasal microbiota and their secreted extracellular vesicles in patients with chronic rhinosinusitis based on a metagenomic analysis. Allergy. 2014;69:517-526.  https://doi.org/10.1111/all.12374
  20. Aurora R, Chatterjee D, Hentzleman J, Prasad G, Sindwani R, Sanford T. Contrasting the microbiomes from healthy volunteers and patients with chronic rhinosinusitis. JAMA Otolaryngology — Head & Neck Surgery. 2013;139:1328. https://doi.org/10.1001/jamaoto.2013.5465
  21. Chalermwatanachai T, Vilchez-Vargas R, Holtappels G, Lacoere T, Jáuregui R, Kerckhof F-M, Pieper DH, de Wiele TV, Vaneechoutte M, Van Zele T, Bachert C. Chronic rhinosinusitis with nasal polyps is characterized by dysbacteriosis of the nasal microbiota. Scientific Reports. 2018;8:7926. https://doi.org/10.1038/s41598-018-26327-2
  22. Anderson M, Stokken J, Sanford T, Aurora R, Sindwani R. A systematic review of the sinonasal microbiome in chronic rhinosinusitis. American Journal of Rhinology & Allergy. 2016;30:161-166.  https://doi.org/10.2500/ajra.2016.30.4320
  23. Cope EK, Goldberg AN, Pletcher SD, Lynch SV. Compositionally and functionally distinct sinus microbiota in chronic rhinosinusitis patients have immunological and clinically divergent consequences. Microbiome. 2017;5:53.  https://doi.org/10.1186/s40168-017-0266-6
  24. Rom D, Bassiouni A, Eykman E, Liu Z, Paramasivan S, Alvarado R, Earls P, Psaltis AJ, Harvey RJ. The association between disease severity and microbiome in chronic rhinosinusitis. Laryngoscope. 2019;129:1265-1273. https://doi.org/10.1002/lary.27726
  25. Liu CM, Kohanski MA, Mendiola M, Soldanova K, Dwan MG, Lester R, Nordstrom L, Price LB, Lane AP. Impact of saline irrigation and topical corticosteroids on the postsurgical sinonasal microbiota. International Forum of Allergy & Rhinology. 2015;5:185-190.  https://doi.org/10.1002/alr.21467
  26. Bendouah Z, Barbeau J, Hamad WA, Desrosiers M. Biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa is associated with an unfavorable evolution after surgery for chronic sinusitis and nasal polyposis. Otolaryngology — Head & Neck Surgery. 2006;134:991-996.  https://doi.org/10.1016/j.otohns.2006.03.001
  27. Bordin A, Sidjabat HE, Cottrell K, Cervin A. Chronic rhinosinusitis: A microbiome in dysbiosis and the search for alternative treatment options. Microbiology Australia. 2016;37(3):149-152.  https://doi.org/10.1071/ma16051
  28. Kumpitsch C, Koskinen K, Schöpf V, Moissl-Eichinger C. The microbiome of the upper respiratory tract in health and disease. BMC Biology. 2019;17:87.  https://doi.org/10.1186/s12915-019-0703-z
  29. Ramakrishnan VR, Holt J, Nelson LF, Ir D, Robertson CE, Frank DN. Determinants of the nasal microbiome: pilot study of effects of intranasal medication use. Allergy & Rhinology (Providence). 2018;9:2152656718789519. https://doi.org/10.1177/2152656718789519
  30. Feazel LM, Robertson CE, Ramakrishnan VR, Frank DN. Microbiome complexity and Staphylococcus aureus in chronic rhinosinusitis. Laryngoscope. 2012;122:467-472.  https://doi.org/10.1002/lary.22398
  31. Ichinohe T, Pang IK, Kumamoto Y, Peaper DR, Ho JH, Murray TS, Iwasaki A. Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(13):5354-5359. https://doi.org/10.1073/pnas.1019378108
  32. Abreu NA, Nagalingam NA, Song Y, Roediger FC, Pletcher SD, Goldberg AN, Lynch SV. Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis. Science Translational Medicine. 2012:4(151);151ra124. https://doi.org/10.1126/scitranslmed.3003783
  33. Maxfield AZ, Korkmaz H, Gregorio LL, Busaba NY, Gray ST, Holbrook EH, Guo R, Bleier BS. General antibiotic exposure is associated with increased risk of developing chronic rhinosinusitis. Laryngoscope. 2017;127:296-302.  https://doi.org/10.1002/lary.26232
  34. Merkley MA, Bice TC, Grier A, Strohl AM, Man L-X, Gill SR. The effect of antibiotics on the microbiome in acute exacerbations of chronic rhinosinusitis. International Forum of Allergy & Rhinology. 2015;5:884-893.  https://doi.org/10.1002/alr.21591
  35. Drilling A, Coombs GW, Tan HL, Pearson JC, Boase S, Psaltis A, Speck P, Vreugde S, Wormald PJ. Cousins, siblings, or copies: the genomics of recurrent Staphylococcus aureus infections in chronic rhinosinusitis. International Forum of Allergy & Rhinology. 2014;4:953-960.  https://doi.org/10.1002/alr.21423
  36. Goggin R, Jardeleza C, Wormald PJ, Vreugde S. Corticosteroids directly reduce Staphylococcus aureus biofilm growth: an in vitro study. Laryngoscope. 2014;124:602-607.  https://doi.org/10.1002/lary.24322
  37. Hauser LJ, Ir D, Kingdom TT, Robertson CE, Frank DN, Ramakrishnan VR. Investigation of bacterial repopulation after sinus surgery and perioperative antibiotics. International Forum of Allergy & Rhinology. 2016;6:34-40.  https://doi.org/10.1002/alr.21630
  38. Jain R, Hoggard M, Biswas K, Zoing M, Jiang Y, Douglas R. Changes in the bacterial microbiome of patients with chronic rhinosinusitis after endoscopic sinus surgery. International Forum of Allergy & Rhinology. 2017;7:7-15.  https://doi.org/10.1002/alr.21849
  39. Singhal D, Foreman A, Jervis-Bardy J, Wormald PJ. Staphylococcus aureus biofilms: Nemesis of endoscopic sinus surgery. Laryngoscope. 2011;121:1578-1583. https://doi.org/10.1002/lary.21805
  40. Jervis-Bardy J, Foreman A, Boase S, Valentine R, Wormald PJ. What is the origin of Staphylococcus aureus in the early postoperative sinonasal cavity? International Forum of Allergy & Rhinology. 2011;1:308-312.  https://doi.org/10.1002/alr.20050
  41. Fiocchi A, Burks W, Bahna SL, Bielory L, Boyle RJ, Cocco R, Dreborg S, Goodman R, Kuitunen M, Haahtela T, Heine RG, Lack G, Osborn DA, Sampson H, Tannock GW, Lee BW. Clinical use of probiotics in pediatric allergy (CUPPA): a World Allergy Organization position paper. World Allergy Organization Journal. 2012;5:148-167.  https://doi.org/10.1097/WOX.0b013e3182784ee0
  42. West CE, Jenmalm MC, Prescott SL. The gut microbiota and its role in the development of allergic disease: a wider perspective. Clinical & Experimental Allergy. 2015;45:43-53.  https://doi.org/10.1111/cea.12332
  43. Hao Q, Lu Z, Dong BR, Huang CQ, Wu T. Probiotics for preventing acute upper respiratory tract infections. Cochrane database of systematic reviews. 2011;7:CD006895. https://doi.org/10.1002/14651858
  44. Cleland EJ, Drilling A, Bassiouni A, James C, Vreugde S, Wormald PJ. Probiotic manipulation of the chronic rhinosinusitis microbiome. International Forum of Allergy & Rhinology. 2014;4:309-314.  https://doi.org/10.1002/alr.21279
  45. Cervin AU. The potential for topical probiotic treatment of chronic rhinosinusitis, a personal perspective. Frontiers in Cellular and Infection Microbiology. 2017;7:530.  https://doi.org/10.3389/fcimb.2017.00530
  46. Mukerji SS, Pynnonen MA, Kim HM, Singer A, Tabor M, Terrell JE. Probiotics as adjunctive treatment for chronic rhinosinusitis: a randomized controlled trial. Otolaryngology — Head & Neck Surgery. 2009;140:202-208.  https://doi.org/10.1016/j.otohns.2008.11.020
  47. Habermann W, Zimmermann K, Skarabis H, Kunze R, Rusch V. Reduction of acute recurrence in patients with chronic recurrent hypertrophic sinusitis by treatment with a bacterial immunostimulant Enterococcus faecalis, bacteriae of human origin. Arzneimittelforschung. 2002;52:622-627.  https://doi.org/10.1055/s-0031-1299941
  48. Psaltis AJ, Wormald PJ. Therapy of sinonasal microbiome in CRS: A critical approach. Current Allergy and Asthma Reports. 2017;17:59.  https://doi.org/10.1007/s11882-017-0726-x
  49. Schwartz JS, Peres AG, Endam MF, Cousineau B, Madrenas J, Desrosiers M. Topical probiotics as a therapeutic alternative for chronic rhinosinusitis: A preclinical proof of concept. American Journal of Rhinology & Allergy. 2016;30:202-205.  https://doi.org/10.2500/ajra.2016.30.4372
  50. Martensson A, Abolhalaj M, Lindstedt M, Martensson A, Olofsson TC, Vásquez A, Greiff L, Cervin A. Clinical efficacy of a topical lactic acid bacterial microbiome in chronic rhinosinusitis: a randomized controlled trial. Laryngoscope Investigative Otolaryngology. 2017;2:410-416.  https://doi.org/10.1002/lio2.93
  51. Szaleniec J, Gorski A, Szaleniec M, Miedzybrodzki R, Weber-Dabrowska B, Strek P, Skladzien J. Can phage therapy solve the problem of recalcitrant chronic rhinosinusitis? Future Microbiology. 2017;12:1427-1442. https://doi.org/10.2217/fmb-2017-0073
  52. Drilling A, Morales S, Jardeleza C, Vreugde, S, Speck P, Wormald PJ. Bacteriophage reduces biofilm of Staphylococcus aureus ex vivo isolates from chronic rhinosinusitis patients. American Journal of Rhinology & Allergy. 2014;28:3-11.  https://doi.org/10.2500/ajra.2014.28.4001
  53. Fong SA, Drilling A, Morales S, Cornet ME, Woodworth BA, Fokkens WJ, Psaltis AJ, Vreugde S, Wormald PJ. Activity of bacteriophages in removing biofilms of Pseudomonas aeruginosa isolates from chronic rhinosinusitis patients. Frontiers in Cellular and Infection Microbiology. 2017;7:418.  https://doi.org/10.3389/fcimb.2017.00418
  54. Zhang G, Zhao Y, Paramasivan S, Richter K, Morales S, Wormald PJ, Vreugde S. Bacteriophage effectively kills multidrug resistant Staphylococcus aureus clinical isolates from chronic rhinosinusitis patients. International Forum of Allergy & Rhinology. 2018;8:406-414.  https://doi.org/10.1002/alr.22046
  55. Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, Toppila-Salmi S, Bernal-Sprekelsen M, Mullol J, Alobid I, Anselmo-Lima WT, Bachert C, Baroody F, von Buchwald C, Cervin A, Cohen N, Constantinidis J, De Gabory L, Desrosiers M, Diamant Z, Douglas RG, Gevaert PH, Hafner A, Harvey RJ, Joos GF, Kalogjera L, Knill A, Kocks JH, Landis BN, Limpens J, Lebeer S, Lourenco O, Matricardi MP, Meco C, O’Mahony L, Philpott CM, Ryan D, Schlosser R, Senior B, Smith TL, Teeling T, Tomazic PV, Wang DY, Wang D, Zhang L, Agius AM, Ahlström-Emanuelsson C, Alabri R, Albu S, Alhabash S, Aleksic A, Aloulah M, Al-Qudah M, Alsaleh S, Baban MA, Baudoin T, Balvers T, Battaglia P, Bedoya JD, Beule A, Bofares KM, Braverman I, Brozek-Madry E, Byaruhanga R, Callejas C, Carrie S, Caulley L, Chussi D, de Corso E, Coste A, El Hadi U, Elfarouk A, Eloy PH, Farrokhi S, Felisati G, Ferrari MD, Fishchuk R, Grayson JW, Goncalves PM, Grdinic B, Grgic V, Hamizan AW, Heinichen JV, Husain S, Ping TI, Ivaska J, Jakimovska F, Jovancevic L, Kakande E, Kamel R, Karpischenko S, Kariyawasam HH, Kawauchi H, Kjeldsen A, Klimek L, Krzeski A, Kopacheva Barsova G, Kim SW, Lal D, Letort JJ, Lopatin A, Mahdjoubi A, Mesbahi A, Netkovski J, Tshipukane DN, Obando-Valverde A, Okano M, Onerci M, Ong YK, Orlandi R, Otori N, Ouennoughy K, Ozkan M, Peric A, Plzak J, Prokopakis E, Prepageran N, Psaltis A, Pugin B, Raftopulos M, Rombaux P, Riechelmann H, Sahtout S, Sarafoleanu C-C, Searyoh K, Rhee C-S, Shi J, Shkoukani M, Shukuryan AK, Sicak M, Smyth D, Snidvongs K, Kosak TS, Stjärne P, Sutikno B, Steinsvåg S, Tantilipikorn P, Thanaviratananich S, Tran T, Urbancic J, Valiulis A, de Aparicio CV, Vicheva D, Virkkula PM, Vicente G, Voegels R, Wagenmann M, Wardani RS, Welge-Lussen A, Witterick I, Wright E, Zabolotniy D, Zsolt B, Zwetsloot CP. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology. 2020;58(Suppl S29):1-464.  https://doi.org/10.4193/Rhin20.600
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.