Preoperative protective preparation of the nasal mucosa of rhinological patients

Berest I.E.

doi:https://doi.org/10.17116/otorino20248905123

Berest I.E.

St. Luke Lugansk State Medical University

ORCID: 0000-0003-1694-341X

Preoperative protective preparation of the nasal mucosa of rhinological patients

Authors:

Berest I.E.

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Journal: Russian Bulletin of Otorhinolaryngology. 2024;89(5): 23‑28

DOI: 10.17116/otorino20248905123

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To cite this article:

Berest IE. Preoperative protective preparation of the nasal mucosa of rhinological patients. Russian Bulletin of Otorhinolaryngology. 2024;89(5):23‑28. (In Russ.)
https://doi.org/10.17116/otorino20248905123

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)

Использование инфографики авторами научных работ

OBJECTIVE

To evaluate the effectiveness of the protective effect of sodium deoxyribonuclease solution on the nasal mucosa in the preoperative period in rhinological patients.

MATERIAL AND METHODS

71 patients were examined after septoplasty with vasotomy of the lower nasal concha for curvature of the nasal septum and vasomotor rhinitis. Patients were divided into two groups: patients of group 1 (n=36) did not undergo protective preoperative preparation; patients of group 2 (n=35) were locally prescribed 0.25% sodium deoxyribonuclease solution as protective therapy. All patients underwent cytological examination of nasal secretions using smear prints at the initial treatment, before surgery, on the 5th, 10th, 21st, 30th, 42nd and 60th days of the postoperative period.

RESULTS

The use of sodium deoxyribonuclease solution in the preoperative period led to statistically significant cytoprotective, anti-inflammatory, reparative and immunostimulating effects compared with the control group. There was a more pronounced and rapid restoration of the cellular composition of the mucous membrane, a decrease in the indices of destruction and cytolysis of cells compared with preoperative indicators.

CONCLUSION

The necessity and effectiveness of preoperative protective preparation of the nasal mucosa in rhinological patients is confirmed by the identified positive therapeutic effects.

Keywords:

preoperative period

mucous membrane

nasal cavity

sodium deoxyribonuclease

Authors:

Berest I.E.

St. Luke Lugansk State Medical University

ORCID: 0000-0003-1694-341X

Received:

24.11.2023

Accepted:

30.05.2024

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References:

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