The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Chekaldina E.V.

GBOU VPO «Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova» Minzdrava Rossii, Moskva, Rossija

Nasal septal perforations: Etiology, pathogenesis, clinical manifestation and treatment (A review of literature)

Authors:

Chekaldina E.V.

More about the authors

Journal: Russian Rhinology. 2016;24(1): 24‑27

DOI: 10.17116/rosrino201624124-27

Views: 2544

Downloaded: 64

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Chekaldina EV. Nasal septal perforations: Etiology, pathogenesis, clinical manifestation and treatment (A review of literature). Russian Rhinology. 2016;24(1):24‑27. (In Russ.)
https://doi.org/10.17116/rosrino201624124-27

 
МСФ на ЯМ
Close metadata
Recommended articles:
Closing of nasal septum perforation using adipose stro­mal vascular fraction: an expe­rimental study. Russian Bulletin of Otorhinolaryngology. 2024;(2):21-27
Surgical treatment of seco­ndary trigeminal neuralgia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):203-209
Granulomatosis with polya­ngiitis. Analysis of two clinical cases from the practice of an otorhinolaryngologist. Russian Bulletin of Otorhinolaryngology. 2024;(6):95-98
Mystery of the illness of the great painter I. Repin. By the 180th anni­versary. Burdenko's Journal of Neurosurgery. 2025;(1):6-10
On the issue of choosing anesthesia methods: a comparison of gene­ral medi­cine and clinical dentistry. Stomatology. 2025;(1):76-80

The review gives the data available in the literature on the prevalence of nasal septal perforations (NSP) and describes the etiological factors leading to their development. It considers iatrogenic (nasal septal surgery, nasal bone repositions) and occupational risk factors and describes the causes of NSP in the abuse of different intranasal substances, because of systemic inflammatory or infectious diseases, neoplasms, as well as those occurring after systemic chemotherapy. The disease symptoms, such as wheezing, dryness, nasal hemorrhage, external nasal deformity, are described according to the sizes and position of NSP; the types of asymptomatic perforations are considered. The paper depicts the medical treatment for large NSP, which is per palliative for this pathology. It presents surgical treatments that are aimed at not perforation closure, but may improve nasal breathing and alleviate the manifestation of the disease. If there are contraindications to plastic NSP closure, a procedure for using nasal septal buttons is proposed as an alternative to surgical treatment.

Keywords:

nasal septal perforation; etiology; submucosal resection of the nasal septum; topical glucocorticosteroids; decongestants; side effects; heavy metal salts; bevacizumab; Wegener’s disease; sarcoidosis; chemotherapy and angiogenesis; classification of perforations; wheezing; saddle nose deformity; medical treatment of nasal septal perforations; nasal septal buttons

Authors:

Chekaldina E.V.

GBOU VPO «Pervyj Moskovskij gosudarstvennyj meditsinskij universitet im. I.M. Sechenova» Minzdrava Rossii, Moskva, Rossija

List of references:

  1. Kridel RW. Considerations in the etiology, treatment, and repair of septal perforations. Facial Plast Surg Clin North Am. 2004;12(4):435-450.  doi:10.1016/j.fsc.2004.04.014. 
  2. Oberg D, Akerlund A, Johansson L, Bende M. Prevalence of nasal septal perforation: the Scovde population-based study. Rhinology. 2003;41(2):72-75.
  3. Bokshtejn F. Vnutrinosovaya khirurgiya. Moscow: Medgiz; 1956:230. (In Russ.)
  4. Meyer R, Berghaus A. Closure of perforations of the septum including a single-session method for large defects. Head Neck Surg. 1983;5(5):390-400.  doi:10.1002/hed.2890050505.
  5. Cervin A, Andersson M. Intranasal steroids and septum perforation - an overlooked complication? A description of the course of events and a discussion of the causes. Rhinology. 1998;36(3):128-132.
  6. Antoniv V, Aksenov M. Sposob plasticheskogo zakrytiya perforatsii nosovoi peregorodki. Rossiiskaya otorinolaringologiya. 1994;Suppl 2:77. (In Russ.)
  7. Akylidiz AM. Septoplasty in perforations of the nasal septum. Int Rhinol. 1983;7:1.
  8. Teichgraeber JF, Riley WB, Parks DH. Nasal surgery complications. Plast Reconstr Surg. 1990;85(4):527-531.
  9. Egorov V, Kazarenko A. Modifikaciya septoplastiki pri iskrivleniyah peregorodki nosa. Rossijskaya rinologiya. 2005;(2):115. (In Russ.)
  10. Gadzhimirzaev G, Gamzatova A, Dzhamaludinov Yu, Gadzhimirzaev R. K ocenke nekotoryh polozhenij hirurgicheskoj korrekcii deformacii peregorodki i naruzhnogo nosa. Rossijskaya rinologiya. 1997;(3):28-29. (In Russ.)
  11. Umarov U, Gulomov Z, Kodiri D, Mirzoeva S, Muhtarova P. Voprosy taktiki hirurgicheskogo lecheniya perelomov kostej nosa. Rossijskaya rinologiya. 2005;(2):122. (In Russ.)
  12. Romo T 3rd, Jablonski RD, Shapiro AL, McCormick SA. Long term nasal mucosal tissue expansion use in repair of large nasoseptal perforations. Arch Otolaryngol Head Neck Surg. 1995;121(3):327-332.  doi:10.1001/archotol.1995.01890030057009.
  13. Ustyanov Yu. K voprosu o lechenii perforacii nosovoj peregorodki. Rossijskaya rinologiya. 1996;(1):65-72. (In Russ.)
  14. Fergison BJ. Nasal steroid sprays and septal perforations. Ear Nose Throat J. 1997;76(2):75-76.
  15. Bende M, Mark J. Long-term effects of topical corticosteroids in the nose. J Laryngol Otol. 1992;106(9):810-812.  doi:10.1017/s0022215100120948.
  16. Chiang MY, Shah P. Nasal septal perforation enlargement related to topical ocular steroids. Br J Clin Pharmacol. 2005;60(6):664-665.  doi:10.1111/j.1365-2125.2005.02486.x. 
  17. Chalaye JC, Levignac J. La reparation des perforations du septum nasal provoquees par la cocaine (ou le lambeau en aile de planeur). Ann Chi. Plast Esthet. 1985;30(3):229-235.
  18. Bekhahaee M, Khadivi E, Naseri Sadr M., Esmatinia F. Nasal Septum Perforation due to Methamphetamine abuse. Iran J Otorhinolaryngol. 2013;25(70):53-56.
  19. Bloomfield JJ, Blum W. Emergency and Continuous Exposure Limits for Selected Airborne Contaminants. Netional Academy Press; 1988:55.
  20. Jindrichová J. Chromium-induced injuries in electric welders. Z Gesamte Hyg. 1978;24(2):86-88.
  21. Lee CR, Yoo CI, Lee Jh, Kang SK. Nasal septum perforation of walders. Ind Health. 2002;40(3):286-289.
  22. Kiger JR, Brenkert TE, Losek JD. Nasal foreign body removal in children. Pediatr Emerg Care. 2008;24(11):785-792.  doi:10.1097/pec.0b013e31818c2cb9.
  23. Chinski A, Foltran F, Gregori D, Passali D, Bellussi L. Nasal foreign bodies: the experience of the Buenos Aires pediatric otolaryngology clinic. Pediatr Int. 2011;53(1):90-93.  doi:10.1111/j.1442-200x.2010.03176.x. 
  24. Zanetta A, Cuestas G, Rodrigues H, Quiroga V. Septal perforation in children due to button battery lodged in the nose: case series. Arch Argent Pediatr. 2012;110(5):430-434.
  25. Ibáñez-Bermúdez F, Castillo Ceballos A, Gallardo Avila A, Pérez Benítez T, Criado Montilla J, Martínez García RC. Wegener’s granulomatosis of the nasal fossa. Acta Otorinolaringol Esp. 1995;46(5):361-364.
  26. Keles MK, Cepni H, Cicekci F, Yenigun A. Nasal septal perforation reconstruction with superior-based pedicled nasolabial island flap in a patient with the raynaud phenomenon. J Сraniofac Surg. 2015;26(3):209-210.  doi:10.1097/scs.0000000000001432.
  27. Baum ED, Boudousquie AC, Li S, Mirza N. Sarcoidosis with nasal obstruction and septal perforation. Ear Nose Throat J. 1998;77(11):896-898, 900-902.
  28. Avcin T, Silverman ED, Forte V, Schneider R. Nasal septal perforation: a novel clinical manifestation of systemic juvenile idiopathic artritis/adult onset Still’s disease. J Rheumatol. 2005;32(12):2429-2431.
  29. Barnes L. Schneiderian pappilomas and nonsalivary glandular neoplasms of the head and neck. Mod Pathol. 2002;15(3):279-297.  doi:10.1038/modpathol.3880524.
  30. Diamantopoulos II, Jones NS. The investigation of nasal septal perforations and ulcers. J Laryngol Otol. 2001;115(7):541-544.  doi:10.1258/0022215011908441.
  31. Burkart CM, Grisel JJ, Hom DB. Spontaneous nasal septal perforation with antiangiogenic bevacizumab therapy. Laryngoscope. 2008;118(9):1539-1541. doi:10.1097/mlg.0b013e31817c4296.
  32. Ramiscal JA, Jatoi A. Nasal septal perforation from bevacizumab: a discussion of outcomes, management, and pharmacovigilance. Curr Oncol Rep. 2012;14(4):307-310.  doi:10.1007/s11912-012-0236-x. 
  33. Shivaprasad A, Ravi GC, Shivapriya, Rama. A Rare Case of Nasal Septal Perforation Due to Purpureocillium lilacinum: Case Report and Review. Indian J Otolaryngol Head Neck Surg. 2013;65(2):184-188.  doi:10.1007/s12070-012-0570-1. 
  34. Meyer R. Nasalseptal perforation must and can be closed. Rossijskaya rinologiya. 1995;(3-4):12-27. (In Russ.)
  35. Lindemann J, Kühnemann S, Stehmer V, Leiacker R, Rettinger G, Keck T. Temperature and humidity profile of the anterior nasal airways of patients with nasal septal perforation. Rhinology. 2001;39(4):202-206.
  36. Leong SC, Chen XB, Lee HP, Wang DY. A review of the implications of computational fluid dynamic studies on nasal airflow and physiology. Rhinology. 2010;48(2):139-145.  doi:10.4193/rhin09.133. 
  37. Fairbanks DN, Fairbanks GR. Nasal septal perforation: prevention and management. Ann Plas. Surg. 1980;5(6):452-459.  doi:10.1097/00000637-198012000-00007.
  38. Ibáñez-Bermúdez F, Castillo Ceballos A, Gallardo Avila A, Pérez Benítez T, Criado Montilla J, Martínez García RC. Wegener’s granulomatosis of the nasal fossa. Acta Otorinolaringol Esp. 1995;46(5):361-364
  39. Mathews JL, Ward JR, Samuelson CO, Knibbe WP. Spontaneous nasal septal perforation in patients with rheumatoid artritis. Clin Reumatol. 1983;2(1):13-18.  doi:10.1007/bf02032063.
  40. Carapkin G, Krjukov A, Artem'ev M. Klinicheskij podhod v vybore taktiki vedeniya bolnyh s perforaciej peregorodki nosa. Rossijskaya Otorinolaringologiya. 2013;(4):55-61. (In Russ.)
  41. Kempf HG, Weber H. Closure of septum perforation using an individual obturator. Laryngorhinootologie. 1991;70(8):436-437.
  42. Mullace M, Gorini E, Scrocca M, Artesi L. Management of nasal septal perforation using silicone nasal septal button. Acta Otorhinolaryng Ital. 2006;26(4):216-218.

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.