Correlation between vitamin D level and autoimmune and non-autoimmune bullous dermatosis. Approaches to adjuvant treatment

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Bullous dermatoses are a group of recurrent, severe diseases, that include autoimmune and non-autoimmune pathological processes. Findings on the immunomodulatory properties of vitamin D, which is successfully used in adjuvant treatment of some skin diseases, were published according to the data of numerous studies. Publications on the concomitant therapy application by vitamin D in allergic and autoimmune processes (type 1 diabetes mellitus, rheumatoid arthritis, multiple sclerosis, atopic dermatitis, psoriasis, vitiligo, systemic lupus erythematosus, Sjogren’s syndrome, etc.) require to study its influence on the course of other autoimmune and non-autoimmune dermatological diseases. Vitamin D has a multifaceted effect on the skin. Immunosuppressive properties are associated with the suppression of antigen-presenting properties of Langerhans cells. In addition, vitamin D has antiprofilative, pro-differentiating, antiapoptotic effects. The influence of vitamin D on the epidermis barrier function is carried out due to the participation in the structural proteins synthesis and regulation of glycosylceramides processing, that are necessary for a lipid barrier formation. Therefore, it’s advisable to study the vitamin D influence on pathological process course in a number of bullous dermatoses.

OBJECTIVE

To develop an approach to adjuvant therapy of patients with pemphigus vulgaris, bullous pemphigoid and benign familial pemphigus based on the use of vitamin D₃ in dosage of 6000 IU/day, to evaluate its effectiveness, influence on patients’ life quality, frequency and severity of pathological process during bullous dermatosis exacerbation.

Keywords:

pemphigus vulgaris

bullous pemphigoid

benign familial pemphigus

vitamin D

PDAI/BPDAI

DLQI

Authors:

Drozhdina M.B.

Kirov State Medical University

ORCID: 0000-0002-7689-8350

Koshkin S.V.

Kirov State Medical University

ORCID: 0000-0002-4699-1212

Received:

09.04.2024

Accepted:

23.07.2024

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