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Drozhdina M.B.

Kirov State Medical University

Koshkin S.V.

Kirov State Medical University

Correlation between vitamin D level and autoimmune and non-autoimmune bullous dermatosis. Approaches to adjuvant treatment

Authors:

Drozhdina M.B., Koshkin S.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2024;23(5): 565‑573

DOI: 10.17116/klinderma202423051565

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Table of contents

CORRELATION BETWEEN VITAMIN D LEVEL AND AUTOIMMUNE AND NON-AUTOIMMUNE BULLOUS DERMATOSIS. APPROACHES TO ADJUVANT TREATMENT
CORRELATION BETWEEN VITAMIN D LEVEL AND AUTOIMMUNE AND NON-AUTOIMMUNE BULLOUS DERMATOSIS. APPROACHES TO ADJUVANT TREATMENT

To cite this article:

Drozhdina MB, Koshkin SV. Correlation between vitamin D level and autoimmune and non-autoimmune bullous dermatosis. Approaches to adjuvant treatment. Russian Journal of Clinical Dermatology and Venereology. 2024;23(5):565‑573. (In Russ.)
https://doi.org/10.17116/klinderma202423051565

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Bullous dermatoses are a group of recurrent, severe diseases, that include autoimmune and non-autoimmune pathological processes. Findings on the immunomodulatory properties of vitamin D, which is successfully used in adjuvant treatment of some skin diseases, were published according to the data of numerous studies. Publications on the concomitant therapy application by vitamin D in allergic and autoimmune processes (type 1 diabetes mellitus, rheumatoid arthritis, multiple sclerosis, atopic dermatitis, psoriasis, vitiligo, systemic lupus erythematosus, Sjogren’s syndrome, etc.) require to study its influence on the course of other autoimmune and non-autoimmune dermatological diseases. Vitamin D has a multifaceted effect on the skin. Immunosuppressive properties are associated with the suppression of antigen-presenting properties of Langerhans cells. In addition, vitamin D has antiprofilative, pro-differentiating, antiapoptotic effects. The influence of vitamin D on the epidermis barrier function is carried out due to the participation in the structural proteins synthesis and regulation of glycosylceramides processing, that are necessary for a lipid barrier formation. Therefore, it’s advisable to study the vitamin D influence on pathological process course in a number of bullous dermatoses.

OBJECTIVE

To develop an approach to adjuvant therapy of patients with pemphigus vulgaris, bullous pemphigoid and benign familial pemphigus based on the use of vitamin D3 in dosage of 6000 IU/day, to evaluate its effectiveness, influence on patients’ life quality, frequency and severity of pathological process during bullous dermatosis exacerbation.

Keywords:

pemphigus vulgaris
bullous pemphigoid
benign familial pemphigus
vitamin D
PDAI/BPDAI
DLQI

Authors:

Drozhdina M.B.

Kirov State Medical University

Koshkin S.V.

Kirov State Medical University

Received:

09.04.2024

Accepted:

23.07.2024

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