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Rymar O.D.

Research Institute of Internal and Preventive Medicine — Branch of Federal Research Center Institute of Cytology and Genetics

Shcherbakova L.V.

Research Institute of Internal and Preventive Medicine — Branch of Federal Research Center Institute of Cytology and Genetics

Mustafina S.V.

Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Simonova G.I.

Research Institute of Internal and Preventive Medicine — Branch of Federal Research Center Institute of Cytology and Genetics Siberian Division of the Russian Academy of Sciences

Dolinskaya Y.A.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Sazonova O.V.

Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences;
Center City Clinical Hospital No. 1

Bakhareva Yu.S.

Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Shishkin S.V.

Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Malyutina S.K.

Research Institute of Internal and Preventive Medicine — Branch of Federal Research Center Institute of Cytology and Genetics

Relationship between heart rate and patients with type 2 diabetes death

Authors:

Rymar O.D., Shcherbakova L.V., Mustafina S.V., Simonova G.I., Dolinskaya Y.A., Sazonova O.V., Bakhareva Yu.S., Shishkin S.V., Malyutina S.K.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2025;28(11): 14‑22

DOI: 10.17116/profmed20252811114

Read: 420 times

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Table of contents

RELATIONSHIP BETWEEN HEART RATE AND PATIENTS WITH TYPE 2 DIABETES DEATH
RELATIONSHIP BETWEEN HEART RATE AND PATIENTS WITH TYPE 2 DIABETES DEATH

To cite this article:

Rymar OD, Shcherbakova LV, Mustafina SV, et al. . Relationship between heart rate and patients with type 2 diabetes death. Russian Journal of Preventive Medicine. 2025;28(11):14‑22. (In Russ.)
https://doi.org/10.17116/profmed20252811114

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To analyze the associations of resting heart rate with the risk of all-cause death in the Siberian cohort of persons aged 45—69 years with type 2 diabetes mellitus.

MATERIAL AND METHODS

The follow-up group included 571 patients with type 2 diabetes mellitus (T2DM): 205 males (35.9%) and 366 females (64.1%). The follow-up period—from 2003—2005 to December 31, 2019—averaged 13.6±3.9 years, with a median of 15.0 years. Fatal events were recorded based on information from the medical certificate of death (form No. 106/y) according to the registry office. Univariate and multivariate Cox regression analyses were used to determine the independent association of heart rate (HR) with a fatal event over a 15-year follow-up period. The studied associations were adjusted for a wide range of «traditional» cardiovascular risk factors. Statistical data were processed using the SPSS software package (v.13.0; v.23.0).

RESULTS

In the sex-combined cohort with T2DM, the hazard ratio of overall death within 15 years was positively associated with a heart rate ≥80/min. In the sex- and age-controlled model, the hazard ratio (HR) was 3.286 (95% CI 1.911—5.651), and in the multiple covariate model, it was 1.543 (95% CI 1.116—2.133). For males with T2DM, a heart rate ≥80 bpm was a significant risk factor for all-cause death, HR=2.773 (1.739—4.423). For females with T2DM, this association was not identified.

CONCLUSION

Heart rate ≥80 bpm in males with type 2 diabetes mellitus is a significant risk factor for all-cause death.

Keywords:

heart rate
type 2 diabetes mellitus
all-cause death
cohort study

Authors:

Rymar O.D.

Research Institute of Internal and Preventive Medicine — Branch of Federal Research Center Institute of Cytology and Genetics

Shcherbakova L.V.

Research Institute of Internal and Preventive Medicine — Branch of Federal Research Center Institute of Cytology and Genetics

Mustafina S.V.

Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Simonova G.I.

Research Institute of Internal and Preventive Medicine — Branch of Federal Research Center Institute of Cytology and Genetics Siberian Division of the Russian Academy of Sciences

Dolinskaya Y.A.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Sazonova O.V.

Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences;
Center City Clinical Hospital No. 1

Bakhareva Yu.S.

Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Shishkin S.V.

Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Malyutina S.K.

Research Institute of Internal and Preventive Medicine — Branch of Federal Research Center Institute of Cytology and Genetics

Received:

28.06.2025

Accepted:

05.11.2025

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