Oxidative stress prevention as an effective preventive strategy in type 2 diabetes mellitus

Close metadata

OBJECTIVE

To study the state, methods and prospects for the prevention of OS in type 2 DM and the possibility of using antioxidants as a preventive strategy based on literature data.

MATERIALS AND METHODS

Fifty-two scientific papers from Cochrane Library, PubMed, eLibrary.ru, and Medscape databases were reviewed. The electronic search period was 2006 to 2023, and the following keyword combinations were used: «diabetes mellitus type 2», «prevention», «oxidative stress», and «antioxidants».

RESULTS

OS is considered an imbalance between the formation of free radicals and a decrease in antioxidant protection, which underlies the pathogenesis of type 2 diabetes mellitus and its complications. OS triggers a cascade of pathophysiological reactions such as inflammation, autophagy, and apoptosis. Of the most informative markers of OS in type 2 DM, malonic dialdehyde, 8-iso-prostaglandin, glutathione and some antioxidant enzymes are considered, which can help diagnose OS and serve as therapeutic targets for preventive therapy. Randomized clinical trials have shown the efficacy of various antioxidants as a preventive strategy in type 2 DM and its complications.

CONCLUSION

To date, the understanding of the role of oxidative stress in the pathophysiology of type 2 diabetes mellitus and its complications, as well as the possibility of using antioxidants as part of preventive therapy, has been significantly expanded. However, the possibility of using antioxidants in a complex of preventive measures and adjuvant therapy for type 2 diabetes mellitus warrants further research.

Keywords:

type 2 diabetes mellitus

diabetic complications

oxidative stress

preventive therapy

Authors:

Bykov Yu.V.

Stavropol State Medical University;
Stavropol City Children’s Clinical Hospital named after G.K. Filippsky

ORCID: 0000-0003-4705-3823

Received:

31.08.2023

Accepted:

08.11.2023

List of references:

Unnikrishnan R, Pradeepa R, Joshi SR, Mohan V. Type 2 Diabetes: Demystifying the Global Epidemic. Diabetes. 2017;66(6):1432-1442. https://doi.org/10.2337/db16-0766
Dinić S, Arambašić Jovanović J, Uskoković A, et al. Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management. Frontiers in Endocrinology. 2022;13:1006376. https://doi.org/10.3389/fendo.2022.1006376
ElSayed NA, Aleppo G, Aroda VR, et al. 2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes—2023. Diabetes Care. 2023; 46(suppl 1):S19-S40. https://doi.org/10.2337/dc23-S002
Rajlic S, Treede H, Münzel T, et al. Early Detection Is the Best Prevention-Characterization of Oxidative Stress in Diabetes Mellitus and Its Consequences on the Cardiovascular System. Cells. 2023;12(4):583. https://doi.org/10.3390/cells12040583
Chu C, Li D, Zhang S, et al. Role of silibinin in the management of diabetes mellitus and its complications. Archives of Pharmacal Research. 2018; 41(8):785-796. https://doi.org/10.1007/s12272-018-1047-x
Niisato N, Marunaka Y. Therapeutic potential of multifunctional myricetin for treatment of type 2 diabetes mellitus. Frontiers in Nutrition. 2023;10: 1175660. https://doi.org/10.3389/fnut.2023.1175660
Sharifi-Rad M, Anil Kumar NV, Zucca P, et al. Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. Frontiers in Physiology. 2020;11:694. https://doi.org/10.3389/fphys.2020.00694
Algoritmy’ specializirovannoj medicinskoj pomoshhi bol’ny’m saxarny’m diabetom. Pod red. Dedova I.I., Shestakovoj M.V., Majorova A.Yu. 11-j vy’pusk. 2023. (In Russ.). https://doi.org/10.14341/DM13042
Bigagli E, Lodovici M. Circulating Oxidative Stress Biomarkers in Clinical Studies on Type 2 Diabetes and Its Complications. Oxidative Medicine And Cellular Longevity. 2019;2019:5953685. https://doi.org/10.1155/2019/5953685
Bykov YuV. The role of oxidative stress in the development of complications in diabetes mellitus. Medicinskij vestnik Severnogo Kavkaza. 2022;3:322-327. (In Russ.). https://doi.org/10.14300/mnnc.2022.17080
Darenskaya MA, Kolesnikova LI, Kolesnikov SI. Oxidative stress: Pathogenetic role in the development of diabetes mellitus and its complications, therapeutic approaches to correction. Bulletin of Experimental Biology and Medicine. 2021;171(2):136-149. https://doi.org/10.47056/0365-9615-2021-171-2-136-149
Seyedsadjadi N, Grant R. The Potential Benefit of Monitoring Oxidative Stress and Inflammation in the Prevention of Non-Communicable Diseases (NCDs). Antioxidants. 2020;10(1):15. https://doi.org/10.3390/antiox10010015
Đorđević MM, Tolić A, Rajić J, et al. Centaurium erythraea methanol extract improves the functionality of diabetic liver and kidney by mitigating hyperglycemia-induced oxidative stress. Journal of Functional Foods. 2022;90: 104975. https://doi.org/10.1016/j.jff.2022.104975
Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: Properties, sources, targets, and their implication in various diseases. Indian Journal of Clinical Biochemistry: IJCB. 2015;30(1):11-26. https://doi.org/10.1007/s12291-014-0446-0
Collin F. Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases. International Journal of Molecular Sciences. 2019;20:2407. https://doi.org/10.3390/ijms20102407
Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. 5th ed. New York: Oxford University Press; 2015. https://doi.org/10.1093/acprof:oso/9780198717478.001.0001
Pizzino G, Irrera N, Cucinotta M, et al. Oxidative Stress: Harms and Benefits for Human Health. Oxidative Medicine and Cellular Longevity. 2017; 2017:8416763. https://doi.org/10.1155/2017/8416763
Akpoveso OP, Ubah EE, Obasanmi G. Antioxidant Phytochemicals as Potential Therapy for Diabetic Complications. Antioxidants. 2023;12(1):123. https://doi.org/10.3390/antiox12010123
Nita M, Grzybowski A. The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults. Oxidative Medicine and Cellular Longevity. 2016;2016:3164734 https://doi.org/10.1155/2016/3164734
Bykov YuV, Baturin VA. The role of oxidative stress in the pathophysiology of type 1 diabetes mellitus. Patogenez. 2022;20(4):35-39. (In Russ.). https://doi.org/10.25557/2310-0435.2022.04.35-39
Cojic M, Kocic R, Klisic A, Kocic G. The Effects of Vitamin D Supplementation on Metabolic and Oxidative Stress Markers in Patients With Type 2 Diabetes: A 6-Month Follow Up Randomized Controlled Study. Frontiers in Endocrinology. 2021;12:610893. https://doi.org/10.3389/fendo.2021.610893
Seyyedebrahimi S, Khodabandehloo H, Nasli Esfahani E, Meshkani R. The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled clinical trial. Acta Diabetologica. 2018;55(4):341-353. https://doi.org/10.1007/s00592-017-1098-3
Darenskaya M, Chugunova E, Kolesnikov S, et al. Receiver Operator Characteristic (ROC) Analysis of Lipids, Proteins, DNA Oxidative Damage, and Antioxidant Defense in Plasma and Erythrocytes of Young Reproductive-Age Men with Early Stages of Type 1 Diabetes Mellitus (T1DM) Nephropathy in the Irkutsk Region, Russia. Metabolites. 2022;12(12):1282. https://doi.org/10.3390/metabo12121282
Chen XF, Wang L, Wu YZ, et al. Effect of puerarin in promoting fatty acid oxidation by increasing mitochondrial oxidative capacity and biogenesis in skeletal muscle in diabetic rats. Nutrition and Diabetes. 2018;8(1):1-13. https://doi.org/10.1038/s41387-017-0009-6
Petrarca C, Viola D. Redox Remodeling by Nutraceuticals for Prevention and Treatment of Acute and Chronic Inflammation. Antioxidants. 2023; 12(1):132. https://doi.org/10.3390/antiox12010132
Yang Y, Wu Y, Sun XD, Zhang Y. Reactive Oxygen Species, Glucose Metabolism, and Lipid Metabolism. Oxidative Stress. 2021;VI:213-235.
Newsholme P, Keane KN, Carlessi R, Cruzat V. Oxidative stress pathways in pancreatic β-cells and insulin-sensitive cells and tissues: Importance to cell metabolism, function, and dysfunction. American Journal of Physiology. Cell Physiology. 2019;317(3):C420-433. https://doi.org/10.1152/ajpcell.00141.2019
Yaribeygi H, Sathyapalan T, Atkin SL, Sahebkar A. Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus. Oxidative Medicine and Cellular Longevity. 2020;2020:8609213. https://doi.org/10.1155/2020/8609213
Mukai E, Fujimoto S, Inagaki N. Role of Reactive Oxygen Species in Glucose Metabolism Disorder in Diabetic Pancreatic beta-Cells. Biomolecules. 2022;12(9):1228. https://doi.org/10.3390/biom12091228
Liu J, Chen S, Biswas S, et al. Glucose-induced oxidative stress and accelerated aging in endothelial cells are mediated by the depletion of mitochondrial SIRTs. Physiological Reports. 2020;8(3):e14331. https://doi.org/10.14814/phy2.14331
Pant T, Uche N, Juric M, Bosnjak ZJ. Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes. Antioxidants. 2023;12(4):898. https://doi.org/10.3390/antiox12040898
Wang L, Shao J, Su C, Yang J. The application of optical technology in the diagnosis and therapy of oxidative stress-mediated hepatic ischemia-reperfusion injury. Frontiers in Bioengineering and Biotechnology. 2023;11:1133039. https://doi.org/10.3389/fbioe.2023.1133039
Frijhoff J, Winyard PG, Zarkovic N, et al. Clinical Relevance of Biomarkers of Oxidative Stress. Antioxidants and Redox Signaling. 2015;23(14): 1144-1170. https://doi.org/10.1089/ars.2015.6317
Korczowska-Łącka I, Hurła M, Banaszek N, et al. Selected Biomarkers of Oxidative Stress and Energy Metabolism Disorders in Neurological Diseases. Molecular Neurobiology. 2023;60(7):4132-4149. https://doi.org/10.1007/s12035-023-03329-4
Ho E, Galougahi KK, Liu CC, et al. Biological markers of oxidative stress: Applications to cardiovascular research and practice. Redox Biology. 2013; 1(1):483-491. https://doi.org/10.1016/j.redox.2013.07.006
Banik S, Ghosh A. The association of oxidative stress biomarkers with type 2 diabetes mellitus: A systematic review and meta-analysis. Health Science Reports. 2021;4(4):e389.
Dąbrowska N, Wiczkowski A. Analytics of oxidative stress markers in the early diagnosis of oxygen DNA damage. Advances in Clinical and Experimental Medicine. 2017;26(1):155-166. https://doi.org/10.17219/acem/43272
Gerber PA, Rutter GA. The role of oxidative stress and hypoxia in pancreatic beta-cell dysfunction in diabetes mellitus. Antioxidants and Redox Signaling. 2017;26(10):501-518. https://doi.org/10.1089/ars.2016.6755
Thakur P, Kumar A, Kumar A. Targeting oxidative stress through antioxidants in diabetes mellitus. Journal of Drug Targeting. 2018;26(9):766-776. https://doi.org/10.1080/1061186X.2017.1419478
Anand S, Bharadvaja N. Potential Benefits of Nutraceuticals for Oxidative Stress Management. Revista Brasileira de Farmacognosia: Orgao Oficial da Sociedade Brasileira de Farmacognosia. 2022;32(2):211-220. https://doi.org/10.1007/s43450-022-00246-w
Chandra K, Singh P, Dwivedi S, Jain SK. Diabetes Mellitus and Oxidative Stress: A Co-relative and Therapeutic Approach. Journal of Clinical and Diagnostic Research. 2019;13(5):7-12. https://doi.org/10.7860/JCDR/2019/40628.12878
Mason SA, Parker L, van der Pligt P, Wadley GD. Vitamin C supplementation for diabetes management: A comprehensive narrative review. Free Radical Biology and Medicine. 2023;194:255-283. https://doi.org/10.1016/j.freeradbiomed.2022.12.003
Kalamkar S, Acharya J, Madathil AK, et al. Randomized Clinical Trial of How Long-Term Glutathione Supplementation Offers Protection from Oxidative Damage and Improves HbA1c in Elderly Type 2 Diabetic Patients. Antioxidants. 2022;11(5):1026. https://doi.org/10.3390/antiox11051026
Jiang YW, Sun ZH, Tong WW, et al. Dietary Intake and Circulating Concentrations of Carotenoids and Risk of Type 2 Diabetes: A Dose-Response Meta-Analysis of Prospective Observational Studies. Advances in Nutrition. 2021;12(5):1723-1733. https://doi.org/10.1093/advances/nmab048
Hussain SA, Khadim HM, Khalaf BH, et al. Effect of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin. Saudi Medical Journal. 2006;27(10):1483-1488.
Abdali D, Samson SE, Grover AK. How Effective Are Antioxidant Supplements in Obesity and Diabetes? Medical Principles and Practice: International Journal of the Kuwait2 University, Health Science Centre. 2015;24(3): 201-215. https://doi.org/10.1159/000375305
Mahjabeen W, Khan DA, Mirza SA. Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial. Complementary Therapies in Medicine. 2022;66:102819. https://doi.org/10.1016/j.ctim.2022.102819
Rodríguez-Carrizalez AD, Castellanos-González JA, Martínez-Romero EC, et al. The effect of ubiquinone and combined antioxidant therapy on oxidative stress markers in non-proliferative diabetic retinopathy: A phase IIa, randomized, double-blind, and placebo-controlled study. Redox Report: Communications in Free Radical Research. 2016;21(4):155-163. https://doi.org/10.1179/1351000215Y.0000000040
Monti LD, Galluccio E, Villa V, et al. Decreased diabetes risk over 9 year after 18-month oral L-arginine treatment in middle-aged subjects with impaired glucose tolerance and metabolic syndrome (extension evaluation of L-arginine study). European Journal of Nutrition. 2018;57(8):2805-2817. https://doi.org/10.1007/s00394-017-1548-2
Bahadoran Z, Mirmiran P, Hosseinpanah F, et al. Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial. European Journal of Clinical Nutrition. 2011;65(8):972-977. https://doi.org/10.1038/ejcn.2011.59
Ghadimi M, Foroughi F, Hashemipour S, et al. Randomized double-blind clinical trial examining the Ellagic acid effects on glycemic status, insulin resistance, antioxidant, and inflammatory factors in patients with type 2 diabetes. Phytotherapy Research. 2021;35(2):1023-1032. https://doi.org/10.1002/ptr.6867
Kaatabi H, Bamosa AO, Badar A, et al. Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: placebo controlled participant blinded clinical trial. PLoS One. 2015; 10(2):e0113486. https://doi.org/10.1371/journal.pone.0113486

Close metadata