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Khidirova L.D.
Novosibirsk State Medical University
Tsygankova O.V.
Novosibirsk State Medical University;
The Institute of Internal and Preventive Medicine — branch of Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences
Lukinov V.L.
The Institute of Computational Mathematics and Mathematical Geophysics SB RAS
Cardiometabolic and psychocognitive features of the post-COVID period in patients with atrial fibrillation
Journal: Russian Journal of Preventive Medicine. 2023;26(4): 43‑50
Views: 2334
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To cite this article:
Starichkova AA, Khidirova LD, Tsygankova OV, Lukinov VL. Cardiometabolic and psychocognitive features of the post-COVID period in patients with atrial fibrillation. Russian Journal of Preventive Medicine.
2023;26(4):43‑50. (In Russ.)
https://doi.org/10.17116/profmed20232604143
The number of people with long-term consequences of COVID-19 is increasing worldwide. The long-term prognosis for patients remains poorly understood.
To study cardiometabolic and psychocognitive features in comorbid elderly patients with atrial fibrillation (AF), depending on the presence of post-COVID syndrome (PCS).
The observational analytical cohort study included 223 patients with AF and comorbidity (coronary artery disease, hypertension, obesity, type 2 diabetes mellitus) aged 60-74, who were divided into two groups: group 1 included 123 patients without COVID-19 and group 2 included 110 patients with a history of COVID-19 and the presence of PCS. The study evaluated laboratory and instrumental tests, and a general clinical study assessing psychocognitive disorders using the SPMSQ and HADS questionnaires was conducted.
In COVID-19 survivors, compared with patients of group 1, there were more pronounced atherogenic changes in total cholesterol (TC) (p=0.003), low-density lipoprotein cholesterol (p<0.001), and triglycerides (p=0.011). Lower diastolic blood pressure was found in COVID-19 survivors (p<0.001). In addition, patients in group 2 had higher median pulse pressure (p<0.001) and heart rate (p<0.001). In group 2 patients, a larger ascending aorta diameter was observed (p<0.001). The anxiety-depressive syndrome was more common in COVID-19 survivors with comorbidities, and a statistically significant difference was found in clinical anxiety (24%, p=0.041) and subclinical depression (21%, p=0.015). When assessing cognitive function, moderate cognitive impairment was detected in 22% (p=0.005) of patients with PCS and severe cognitive impairment in 2% (p=0.007).
In comorbid elderly patients with the post-COVID syndrome, a high prevalence of psychocognitive disorders and adverse cardiometabolic changes were observed, supporting the need for long-term monitoring of the general clinical condition and psychocognitive status of COVID-19 survivors.
Keywords:
Authors:
Khidirova L.D.
Novosibirsk State Medical University
Tsygankova O.V.
Novosibirsk State Medical University;
The Institute of Internal and Preventive Medicine — branch of Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences
Lukinov V.L.
The Institute of Computational Mathematics and Mathematical Geophysics SB RAS
Received:
13.12.2022
Accepted:
26.12.2022
List of references:
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