Arterial hypertension and metabolic syndrome in non-indigenous residents of the Far North

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OBJECTIVE

To characterize the structure of metabolic syndrome by its components in non-indigenous individuals with arterial hypertension permanently residing in the Far North.

MATERIAL AND METHODS

The study included 308 patients with arterial hypertension (AH) and metabolic syndrome (MS) permanently residing in the Far North (Khanty-Mansi Autonomous Okrug, Ugra) in the period 2016—2019. There were 142 (46.1%) males and 166 (53.9%) females. The age of the study participants was 41±5.1 years. All patients were divided into two groups according to their age: Group 1 — 36—40 years (n=150), Group 2 — 41—46 years (n=158). The patients had the following AH severity distribution: Grade 1 AH (n=91), Grade 2 AH (n=125), Grade 3 AH (n=92). The MS diagnose in this study was made according to the Guidelines for the Management of Patients with Metabolic Syndrome (2013).

RESULTS

MS in patients with AH living in the Far North is represented by the following combinations of 3, 4, and 5 elements. At the same time in patients with Grade 1 AH, a 3-component variant of MS is registered, whereas for the patients with Grade 2 AH and especially for the patients with Grade 3 AH, 4-component and 5-component MS variants were typical respectively.

CONCLUSION

A close pathogenetic relationship is defined between obesity and arterial hypertension. On the one hand, obesity is the trigger mechanism for arterial hypertension; on the other hand, arterial hypertension causes decreased sensitivity of peripheral tissues to insulin, which leads to obesity. Overweight individuals are 50% more likely to develop arterial hypertension than normal weight individuals. Arterial hypertension is associated with the central type of obesity, which causes symptoms such as insulin resistance, impaired glucose tolerance, and dyslipidemia.

Keywords:

metabolic syndrome

arterial hypertension

males

females

Authors:

Ivanova E.G.

Privolzhsky Research Medical University

Fomin I.V.

Privolzhsky Research Medical University

Received:

15.03.2022

Accepted:

28.06.2022

List of references:

Uspenskij YuP, Petrenko YuV, Gulunov ZH, Shaporova NL, Fominyh YuA, Niyazov RM. Metabolicheskij sindrom. Uchebnoe posobie. SPb.: SPbGPMU; 2017. (In Russ.).
Volkov VP. Metabolic syndrome: history of the issue. Universum: medicina i farmakologiya. 2017;38(4):36-45. (In Russ.).
Metabolicheskij sindrom. Pod red. chl.-korr. RAMN Rojtberga G.E. M.: MED-press-inform; 2007. (In Russ.).
Grinshtein YuI, Shabalin VV, Ruf RR, Shalnova SA. Prevalence of metabolic syndrome in the population of the Krasnoyarsk Territory and features of its association with hyperuricemia. Rossijskij kardiologicheskij zhurnal. 2020; 25(6):3852. (In Russ.). https://doi.org/10.15829/1560-4071-2020-3852
Saklayen MG. The Global Epidemic of the Metabolic Syndrome. Current Hypertension Reports. 2018;20(2):12. https://doi.org/10.1007/s11906-018-0812-z
Drapkina OM, Eliashevich SO, Shepel RN. Obesity as a risk factor for chronic noncommunicable diseases. Rossijskij kardiologicheskij zhurnal. 2016; 6(134):73-79. (In Russ.). https://doi.org/10.15829/1560-4071-2016-6-73-79
Shalnova SA, Deev AD, Balanova YuA, Kapustina AV, Imaeva AE, Muromceva GA, Kiseleva NV, Bojcov SA. Twenty-year trends in obesity and arterial hypertension and their associations in Russia. Kardiovaskulyarnaya terapiya i profilaktika. 2017;16(4):4-10. (In Russ.). https://doi.org/10.15829/1728-8800-2017-4-4-10
Rotar’ OP, Libis RA, Isaeva EN, Erina AM, Shavshin DA, Moguchaya EV, Kolesova EP, Boyarinova MA, Moroshkina NV, Yakovleva OI, Solncev VN, Konradi AO, Shlyahto EV. Prevalence of metabolic syndrome in different cities of the Russian Federation. Rossijskij kardiologicheskij zhurnal. 2012; (2):55-62. (In Russ.).
Khasnulin VI, Boyko ER, Khasnulina AV. Osnovy tradicionnyh racionov pitaniya korennyh zhitelej Severa. Materialy mezhdunarodnoj konf. «Mediko-social’nye problemy korennyh malochislennyh narodov Severa». Hanty-Mansijsk, 29—30 sentyabrya 2005 goda. Hanty-Mansijsk: Hanty-Mansijskij gosudarstvennyj medicinskij institut; 2005;265-267. (In Russ.).
Korneeva EV, Trekina NE, Mamina AA. The influence of eating behavior and physical activity on the development of metabolic syndrome in a young working-age population living for a long time in the Far North. Kardiovaskulyarnaya terapiya i profilaktika. 2015;14(1):41-46. (In Russ.). https://doi.org/10.15829/1728-8800-2015-1-41-46
Simonova GI, Pechenkina EA, Shcherbakova LV. Rasprostranennost’ metabolicheskogo sindroma i ego komponentov v Sibiri. Tezisy dokladov konferencii «Aktual’nye voprosy diagnostiki i lecheniya metabolicheskogo sindroma». M. 2006;17. (In Russ.).
Nebesnykh AL. The characteristics of metabolic syndrome manifestations in different ethnic groups. Sibirskiy meditsinskiy zhurnal. 2013;122(7):19-23. (In Russ.).
Nikitin YuP, Voevoda MI, Simonova GI. Diabetes mellitus and metabolic syndrome in Siberia and in the Far East. Vestnik Rossijskoj akademii medicinskih nauk. 2012;67(1):66-74. (In Russ.). https://doi.org/10.15690/vramn.v67i1.113
Oganov RG, Simanenkov VI, Bakulin IG, Bakulina NV, Barbarash OL, Bojcov SA, Boldueva SA, Garganeeva NP, Doshchicin VL, Karateev AE, Kotovskaya YuV, Lila AM, Luk’yanov MM, Morozova TE, Pereverzev AP, Petrova MM, Pozdnyakov YuM, Syrov AV, Tarasov AV, Tkacheva ON, Shal’nova SA. Comorbid pathology in clinical practice. Diagnostic and treatment algorithms. Kardiovaskulyarnaya terapiya i profilaktika. 2019;18(1):5-66. (In Russ.). https://doi.org/10.15829/1728-8800-2019-1-5-66
Rekomendacii po vedeniyu bol’nyh s metabolicheskim sindromom. Klinicheskie rekomendacii. 2013. Accessed July 07, 2022. (In Russ.). https://cardioweb.ru/files/Klinicheskie_rekomendacii/Diagnostika_i_lechenie_metabolicheskogo_sindroma.docx
Pucci G, Alcidi R, Tap L, Battista F, Mattace-Raso F, Schillaci G. Sex- and gender-related prevalence, cardiovascular risk and therapeutic approach in metabolic syndrome: A review of the literature. Pharmacological Research. 2017;120:34-42. https://doi.org/10.1016/j.phrs.2017.03.008
Zapesochnaya IL, Avtandilov AG. Problema adaptacii serdechno-sosudistoj sistemy pri prozhivanii na Krajnem Severe: uchebnoe posobie. M.: GBOU DPO RMAPO; 2015. (In Russ.).
Kannel WB, Cuppels LA, Ramaswami R, Stokes J, Kreger BE. Higgis m regional obesity and risk of cardivascular disease; the Framingham study. Journal of Clinical Epidemiology. 1991;44(2):183-190. https://doi.org/10.1016/0895-4356(91)90265-b
Tanashyan MM, Lagoda OV, Antonova KV. Cerebrovaskulyarnaya patologiya i metabolicheskij sindrom. Monografiya. M.: AST 345; 2019. (In Russ.).

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