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Bolshakova S.E.

Scientific Centre for Family Health and Human Reproduction Problems

Madaeva I.M.

Scientific Centre for Family Health and Human Reproduction Problems

Berdina O.N.

Scientific Centre for Family Health and Human Reproduction Problems

Bugun O.V.

Scientific Centre for Family Health and Human Reproduction Problems

Rychkova L.V.

Scientific Centre for Family Health and Human Reproduction Problems

Biomarkers of endothelial dysfunction as a cardiovascular risk factor in patients obstructive sleep apnea syndrome

Authors:

Bolshakova S.E., Madaeva I.M., Berdina O.N., Bugun O.V., Rychkova L.V.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2022;25(8): 114‑119

DOI: 10.17116/profmed202225081114

Read: 1533 times

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Table of contents

BIOMARKERS OF ENDOTHELIAL DYSFUNCTION AS A CARDIOVASCULAR RISK FACTOR IN PATIENTS OBSTRUCTIVE SLEEP APNEA SYNDROME
BIOMARKERS OF ENDOTHELIAL DYSFUNCTION AS A CARDIOVASCULAR RISK FACTOR IN PATIENTS OBSTRUCTIVE SLEEP APNEA SYNDROME

To cite this article:

Bolshakova SE, Madaeva IM, Berdina ON, Bugun OV, Rychkova LV. Biomarkers of endothelial dysfunction as a cardiovascular risk factor in patients obstructive sleep apnea syndrome. Russian Journal of Preventive Medicine. 2022;25(8):114‑119. (In Russ.)
https://doi.org/10.17116/profmed202225081114

 
Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The high prevalence of obstructive sleep apnea syndrome and its association with various diseases, primarily obesity, and arterial hypertension, warrants a search for and study of biomarkers of pathological mechanisms underlying the development of various cardiovascular complications. This review addresses biomarkers of endothelial dysfunction as a key mechanism of cardiovascular disease development. The detection of these biomarkers at the early (preclinical) stage of the disease will reduce the risk of cardiovascular complications, morbidity, and mortality in patients with obstructive sleep apnea syndrome.

Keywords:

obstructive sleep apnea syndrome
endothelial dysfunction
cardiovascular risk
biomarkers

Authors:

Bolshakova S.E.

Scientific Centre for Family Health and Human Reproduction Problems

Madaeva I.M.

Scientific Centre for Family Health and Human Reproduction Problems

Berdina O.N.

Scientific Centre for Family Health and Human Reproduction Problems

Bugun O.V.

Scientific Centre for Family Health and Human Reproduction Problems

Rychkova L.V.

Scientific Centre for Family Health and Human Reproduction Problems

Received:

21.04.2022

Accepted:

26.05.2022

Close metadata

References:

  1. Yeghiazarians Y, Jneid H, Tietjens JR, Redline S, Brown, DL, El-Sherif N, Mehra R, Bozkurt B, Ndumele CE, Somers VK. Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement from the American Heart Association. Circulation. 2021;144(3):56-67.  https://doi.org/10.1161/CIR.0000000000000988
  2. Benjafield AV, Ayas NT, Eastwood PR, Heinzer R, Ip MSM, Morrell MJ, Nunez CM, Patel SR, Penzel T, Pépin JL, Peppard PE, Sinha S, Tufik S, Valentine K, Malhotra A. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respiratory Medicine. 2019;7(8):687-698.  https://doi.org/10.1016/S2213-2600(19)30198-5
  3. Overland B, Berdal H, Akre H. Obstructive sleep apnea in 2—6 year old children referred for adenotonsillectomy. European Archives of Oto-Rhino-Laryngology. 2019;276(7):2097-2104. https://doi.org/10.1007/s00405-019-05362-3
  4. Bin-Hasan S, Katz S, Nugent Z, Nehme J, Lu Z, Khayat A, Al-Saleh S, Amin R, Narang I. Prevalence of obstructive sleep apnea among obese toddlers and preschool children. Sleep Breathing. 2018;22(2):511-515.  https://doi.org/10.1007/s11325-017-1576-4
  5. Madaeva I, Berdina O, Polyakov V, Kolesnikov S. Obstructive sleep apnea and hypertension in adolescents: effect on neurobehavioral and cognitive functioning. Canadian Respiratory Journal. 2016;2016:3950914. https://doi.org/10.1155/2016/3950914
  6. Pogodina A, Rychkova L, Kravtzova O, Klimkina Ju, Kosovtzeva A. Cardiometabolic risk factors and health-related quality of life in adolescents with obesity. Childhood Obesity. 2017;13(6):499-506.  https://doi.org/10.1089/chi.2016.0330
  7. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical SpecificaJons, Version 2.0.  https://aasm.org/clinical-resources/scoring-manual/
  8. Geovanini GR, Wang R, Weng J, Jenny NS, Shea S, Allison M, Libby P, Redline S. Association between Obstructive Sleep Apnea and Cardiovascular Risk Factors: Variation by Age, Sex, and Race. The Multi-Ethnic Study of Atherosclerosis. Annals of the American Thoracic Society. 2018; 15(8):970-977.  https://doi.org/10.1513/AnnalsATS.201802-121OC
  9. Madaeva IM, Shevyrtalova ON, Dolgih VV. Arterial hypertension and respiratory disorders during sleep in pediatrics: results of a pilot study. Sistemnye gipertenzii. 2009;2:28-31. (In Russ.).
  10. Berdina ON, Rychkova LV, Madaeva IM. Sleep disorders and obesity in adolescents: features of the psychocognitive state. Acta Biomedica Scientifica. 2017;2(5-2):93-98. (In Russ.). https://doi.org/10.12737/article_5a3a0e4a4bd9c6.35862127
  11. Tzeng NS, Chung CH, Chang HA, Chang CC, Lu RB, Yeh HW, Chiang WS, Kao YC, Chang SY, Chien WC. Obstructive Sleep Apnea in Children and Adolescents and the Risk of Major Adverse Cardiovascular Events: A Nationwide Cohort Study in Taiwan. Journal of Clinical Sleep Medicine: JCSM. 2019;15(2):275-283.  https://doi.org/10.5664/jcsm.7632
  12. Kheirandish-Gozal L, Philby MF, Qiao Z, Khalyfa A, Gozal D. Endothelial dysfunction in children with obstructive sleep apnea is associated with elevated lipoprotein-associated phospholipase A2 plasma activity levels. Journal of the American Heart Association. 2017;6(2):e004923. https://doi.org/10.1161/JAHA.116.004923
  13. Kanbay A, Ceylan E, Köseoğlu Hİ, Çalışkan M, Takir M, Tulu S, TelciÇaklılı O, Köstek O, Erek A, Afsar B. Endocan: a novel predictor of endothelial dysfunction in obstructive sleep apnea syndrome. The Clinical Respiratory Journal. 2018;12(1):84-90.  https://doi.org/10.1111/crj.12487
  14. Rodrigues SF, Granger DN. Blood cells and endothelial barrier function. Tissue Barriers. 2015;3(1-2):e978720. https://doi.org/10.4161/21688370.2014.978720
  15. Vlasov TD, Nesterovich II, Shimanski DA. Endothelial dysfunction: from the particular to the general. Return to the «Old Paradigm»? Regionarnoe krovoobrashchenie i mikrocirkulyaciya. 2019;18(2):19-27. (In Russ.). https://doi.org/10.24884/1682-6655-2019-18-2-19-27
  16. Ivanov AN, Popykhova EB, Tereshkina NE, Stepanova TV, Zlobina OV, Norkin IA. Vasomotor function of the endothelium. Uspekhi fiziologicheskih nauk. 2020;51(4):82-104. (In Russ.). https://doi.org/10.31857/S0301179820030066
  17. Li MM, Zheng YL, Wang WD, Lin S, Lin HL. Neuropeptide Y: An Update on the Mechanism Underlying Chronic Intermittent Hypoxia-Induced Endothelial Dysfunction. Frontiers in Physiology. 2021;12:712281. https://doi.org/10.3389/fphys.2021.712281
  18. Balta S, Balta I, Mikhailidis DP. Endocan: a new marker of endothelial function. Current Opinion in Cardiology. 2021;36(4):462-468.  https://doi.org/10.1097/HCO.0000000000000867
  19. Bironneau V, Tamisier R, Trzepizur W, Andriantsitohaina R, Berger M, Goupil F, Joyeux-Faure M, Jullian-Desayes I, Launois S, Le Vaillant M, Martinez MC, Roche F, Pépin JL, Gagnadoux F. Sleep apnoea and endothelial dysfunction: An individual patient data meta-analysis. Sleep Medicine Reviews. 2020;52:101309. https://doi.org/10.1016/j.smrv.2020.101309
  20. Zhang F, Wu Y, Feng G, Ni X, Xu Z, Gozal D. Polysomnographic correlates of endothelial function in children with obstructive sleep apnea. Sleep Medicine. 2018;52:45-50.  https://doi.org/10.1016/j.sleep.2018.07.023
  21. Joyeux-Faure M, Tamisier R, Borel JC, Millasseau S, Galerneau LM, Destors M, Bailly S, Pepin JL. Contribution of obstructive sleep apnoea to arterial stiffness: a meta-analysis using individual patient data. Thorax. 2018; 73(12):1146-1151. https://doi.org/10.1136/thoraxjnl-2018-211513
  22. Jankowich M, Choudhary G. Endothelin-1 levels and cardiovascular events. Trends in Cardiovascular Medicine. 2020;30(1):1-8.  https://doi.org/10.1016/j.tcm.2019.01.007
  23. Kosacka M, Brzecka A. Endothelin-1 and LOX-1 as Markers of Endothelial Dysfunction in Obstructive Sleep Apnea Patients. International Journal of Environmental Research and Public Health. 2021;18(3):1319. https://doi.org/10.3390/ijerph18031319
  24. Lin G, Chen Q, Huang J, Chen L, Lin T, Lin Q. Effect of continuous positive airway pressure on endothelin-1 in patients with obstructive sleep apnea: a meta-analysis. European Archives of Oto-Rhino-Laryngology. 2019; 276(3):623-630.  https://doi.org/10.1007/s00405-018-5225-8
  25. Cyr AR, Huckaby LV, Shiva SS, Zuckerbraun BS. Nitric Oxide and Endothelial Dysfunction. Critical Care Clinics. 2020;36(2):307-321.  https://doi.org/10.1016/j.ccc.2019.12.009
  26. Wu ZH, Tang Y, Niu X, Sun HY. The role of nitric oxide (NO) levels in patients with obstructive sleep apnea-hypopnea syndrome: a meta-analysis. Sleep and Breathing. 2021;25(1):9-16.  https://doi.org/10.1007/s11325-020-02095-0
  27. Brożyna-Tkaczyk K, Myśliński W, Mosiewicz J. The Assessment of Endothelial Dysfunction among OSA Patients after CPAP Treatment. Medicina (Kaunas). 2021;57(4):310.  https://doi.org/10.3390/medicina57040310
  28. Qi JC, Zhang L, Li H, Zeng H, Ye Y, Wang T, Wu Q, Chen L, Xu Q, Zheng Y, Huang Y, Lin L. Impact of continuous positive airway pressure on vascular endothelial growth factor in patients with obstructive sleep apnea: a meta-analysis. Sleep and Breathing. 2019;23(1):5-12.  https://doi.org/10.1007/s11325-018-1660-4
  29. Muñoz-Hernandez R, Vallejo-Vaz AJ, Sanchez Armengol A, Moreno-Luna R, Caballero-Eraso C, Macher HC, Villar J, Merino AM, Castell J, Capote F, Stiefel P. Obstructive sleep apnoea syndrome, endothelial function and markers of endothelialization. Changes after CPAP. PLoS One. 2015;10(3):e0122091. https://doi.org/10.1371/journal.pone.0122091
  30. Liu YL, Luo SH, Ou Q, Yuan P, Lu MZ, Chen JN, Luo ZR, Lao MC, Cui JH, Gao XL. [The expressions of CTLA-4 and PD-1 on CD(4)(+) T cells and the level of plasma VEGF in patients with obstructive sleep apnea hypopnea syndrome]. Zhonghua Jie He He Hu Xi Za Zhi. 2019;42(4):268-274.  https://doi.org/10.3760/cma.j.issn.1001-0939.2019.04.004
  31. Chen J, Jiang L, Yu XH, Hu M, Zhang YK, Liu X, He P, Ouyang X. Endocan: A Key Player of Cardiovascular Disease. Frontiers in Cardiovascular Medicine. 2022;8:798699. https://doi.org/10.3389/fcvm.2021.798699
  32. Gunay M, Mertoglu C. Increase of endocan, a new marker for inflammation and endothelial dysfunction, in acute kidney injury. Northern Clinics of Istanbul. 2018;6(2):124-128.  https://doi.org/10.14744/nci.2018.70446
  33. Klisić A, Kavarić N, Spasojević-Kalimanovska V, Kotur-Stevuljević J, Ninić A. Serum endocan levels in relation to traditional and non-traditional anthropometric indices in adult population. Journal of Medical Biochemistry. 2021;40(1):41-48.  https://doi.org/10.5937/jomb0-25170
  34. Altintas N, Mutlu LC, Akkoyun DC, Aydin M, Bilir B, Yilmaz A, Malhotra A. Effect of CPAP on New Endothelial Dysfunction Marker, Endocan, in People With Obstructive Sleep Apnea. Angiology. 2016;67(4):364-74.  https://doi.org/10.1177/0003319715590558
  35. Fan Z, Zhang Y, Zou F, Xu T, Pan P, Hu C, Su X. Serum adropin level is associated with endothelial dysfunction in patients with obstructive sleep apnea and hypopnea syndrome. Sleep and Breathing. 2021;25(1):117-123.  https://doi.org/10.1007/s11325-020-02072-7
  36. Bozic J, Borovac JA, Galic T, Kurir TT, Supe-Domic D, Dogas Z. Adropin and Inflammation Biomarker Levels in Male Patients With Obstructive Sleep Apnea: A Link With Glucose Metabolism and Sleep Parameters. Journal of Clinical Sleep Medicine: JCSM. 2018;14(7):1109-1118. https://doi.org/10.5664/jcsm.7204
  37. Gozal D, Kheirandish-Gozal L, Bhattacharjee R, Molero-Ramirez H, Tan HL, Bandla HP. Circulating adropin concentrations in pediatric obstructive sleep apnea: potential relevance to endothelial function. The Journal of Pediatrics. 2013;163(4):1122-1126. https://doi.org/10.1016/j.jpeds.2013.05.040
  38. Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017;9(6):7204-7218. https://doi.org/10.18632/oncotarget.23208
  39. Kolesnikova LI, Semenova NV, Osipova EV, Madaeva IM. Lipid status and oxidative stress in obstructive sleep apnea syndrome in menopausal women. Terapevticheskii arkhiv. 2019;91(10):48-53. (In Russ.). https://doi.org/10.26442/00403660.2019.10.000050
  40. Denegri A, Boriani G. High Sensitivity C-reactive Protein (hsCRP) and its Implications in Cardiovascular Outcomes. Current Pharmaceutical Design. 2021;27(2):263-275.  https://doi.org/10.2174/1381612826666200717090334
  41. Zicari AM, Occasi F, Di Mauro F, Lollobrigida V, Di Fraia M, Savastano V, Loffredo L, Nicita F, Spalice A, Duse M. Mean platelet volume, vitamin D and C reactive protein levels in normal weight children with primary snoring and obstructive sleep apnea syndrome. PLoS One. 2016;11(4):e0152497. https://doi.org/10.1371/journal.pone.0152497
  42. Van Eyck A, Van Hoorenbeeck K, De Winter BY, Ramet J, Van Gaal L, De Backer W, Verhulst SL. Sleep-disordered breathing and C-reactive protein in obese children and adolescents. Sleep and Breathing. 2014;18(2):335-340.  https://doi.org/10.1007/s11325-013-0890-8
  43. Imani MM, Sadeghi M, Farokhzadeh F, Khazaie H, Brand S, Dürsteler KM, Brühl A, Sadeghi-Bahmani D. Evaluation of Blood Levels of C-Reactive Protein Marker in Obstructive Sleep Apnea: A Systematic Review, Meta-Analysis and Meta-Regression. Life (Basel). 2021;11(4):362.  https://doi.org/10.3390/life11040362
  44. Kattoor AJ, Goel A, Mehta JL. LOX-1: Regulation, Signaling and Its Role in Atherosclerosis. Antioxidants. 2019;8(7):218.  https://doi.org/10.3390/antiox8070218
  45. Tian K, Ogura S, Little PJ, Xu SW, Sawamura T. Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives. Annals of the New York Academy of Sciences. 2019;1443(1):34-53.  https://doi.org/10.1111/nyas.13984
  46. Xu CY, Li DJ, Wu CL, Lou HJ, Jiang HW, Ding GQ. Serum sLOX-1 Levels Are Correlated with the Presence and Severity of Obstructive Sleep Apnea. Genetic Testing and Molecular Biomarkers. 2015;19(5):272-276.  https://doi.org/10.1089/gtmb.2015.0027
  47. Jayatilleke KM, Hulett MD. Heparanase and the hallmarks of cancer. Journal of Translational Medicine. 2020;18(1):453.  https://doi.org/10.1186/s12967-020-02624-1
  48. Ozkok A, Ozkok S, Takır M, Yakar Hİ, Kanbay A. Serum heparanase levels are associated with endothelial dysfunction in patients with obstructive sleep apnea. The Clinical Respiratory Journal. 2018;12(4):1693-1699. https://doi.org/10.1111/crj.12731
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