Epidemiological analysis of prostate cancer risk factors

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OBJECTIVE

To study the effects of various factors on prostate cancer risk.

MATERIALS AND METHODS

An epidemiological analytical retrospective selective case-control study was performed. The study group included 305 subjects with prostate cancer (PCa), and the comparison group included 330 urological patients without PCa. We used the results of a direct open survey, data from outpatient (no. 025/y) and inpatient (no. 003/y) medical records of all participants, as well as the results of DNA genotyping of 200 patients.

RESULTS

The main risk factors for developing PCa were age over 50 years (OR 265.26; 95% CI 126.04—558.26; p<0.0001), hereditary background (OR 4.08; 95% CI 1.43—14.20; p=0.006) and the presence of (CAG)n AR gene polymorphism (OR 4.38; 95% CI 2.36—7.82; p<0.0001). The role of ethnicity, hypokinesia (p=0.002), smoking (p<0.001), alcohol consumption (p<0.001), fatty foods (p=0.03), and history of chronic prostatitis (p=0.014), and a high concentration of total testosterone (p<0.001) was studied.

CONCLUSION

The study results clarify the prostate cancer etiology and can be used to improve preventive measures in the region.

Keywords:

prostate cancer

risk factors

testosterone

dyslipidemia

genetic polymorphism

Authors:

Smirnov A.V.

Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies

ORCID: 0000-0001-5351-6105

Brusina E.B.

Kemerovo State Medical University

Magaryll Yu.A.

Kemerovo State Medical University

Gordeeva L.A.

Federal Research Center for Coal and Coal Chemistry of the Siberian Branch of the Russian Academy of Sciences

Received:

04.05.2022

Accepted:

23.05.2022

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