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Ignatova G.L.

South Ural State Medical University

Blinova E.V.

I.M. Sechenov First Moscow State Medical University

Clinical and functional characteristics of patients with chronic obstructive pulmonary disease and bronchiectasis: results of a 10-year prospective observational study

Authors:

Ignatova G.L., Blinova E.V.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2022;25(11): 54‑60

DOI: 10.17116/profmed20222511154

Read: 1970 times

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Table of contents

CLINICAL AND FUNCTIONAL CHARACTERISTICS OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND BRONCHIECTASIS: RESULTS OF A 10-YEAR PROSPECTIVE OBSERVATIONAL STUDY
CLINICAL AND FUNCTIONAL CHARACTERISTICS OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND BRONCHIECTASIS: RESULTS OF A 10-YEAR PROSPECTIVE OBSERVATIONAL STUDY

To cite this article:

Ignatova GL, Blinova EV. Clinical and functional characteristics of patients with chronic obstructive pulmonary disease and bronchiectasis: results of a 10-year prospective observational study. Russian Journal of Preventive Medicine. 2022;25(11):54‑60. (In Russ.)
https://doi.org/10.17116/profmed20222511154

 
 
 
Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The problem of concomitant chronic obstructive pulmonary disease (COPD) and bronchiectasis is currently urgent and poorly studied.

OBJECTIVE

The objective is to analyze the clinical and functional features of COPD courses in patients with bronchiectasis according to the results of a 10-year observation.

MATERIAL AND METHODS

The study included 141 male patients. They were divided into two observation groups. Group 1 (n=68) included patients with COPD only, mean age of 60.67 (95% CI 51.45; 69.89) years; group 2 (n=73) included patients with concomitant COPD and bronchiectasis, mean age of 68.4 (95% CI 60.35; 76.45) years. Frequency and duration of COPD exacerbations, number of hospital admissions, pneumonia episodes, COPD symptoms severity according to COPD Assessment Test (CAT), dyspnea severity using Modified Medical Research Council questionnaire (mMRC), postbronchodilator forced expiratory volume in 1 second were estimated.

RESULTS

It was found that patients with COPD and bronchiectasis were statistically significantly older, had a longer disease course, a higher smoking intensity, and a lower body mass index compared to patients with COPD only. The clinical course of COPD with bronchiectasis was characterized by more severe dyspnea, more severe bronchial obstruction, frequent (≥2 episodes per year) and prolonged exacerbations of COPD, repeated hospitalizations, and associated with the risk of adverse outcomes. The mortality in patients with COPD and bronchiectasis was 1.9 times higher than in the control group.

CONCLUSION

The development of bronchiectasis in patients with chronic obstructive pulmonary disease significantly worsens the course of the disease and increases the risk of adverse outcomes. Early detection of bronchiectasis using chest CT is necessary for patients with COPD.

Keywords:

chronic obstructive pulmonary disease
bronchiectasis
clinical manifestations
prognosis

Authors:

Ignatova G.L.

South Ural State Medical University

Blinova E.V.

I.M. Sechenov First Moscow State Medical University

Received:

19.08.2022

Accepted:

31.08.2022

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