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Shatova O.P.
Pirogov Russian National Research Medical University
Zabolotneva A.A.
Pirogov Russian National Research Medical University
Mikin I.E.
All-Russian Non-Governmental Organization of Small and Medium Business «Opora Russia»
Bril D.V.
International Association of Research, Environmental, Medical and Educational Organizations, Producers and Consumers of Goods and Services in the Field of Public Health and Active Longevity «Quality of Life»
Shestopalov A.V.
Pirogov Russian National Research Medical University;
Molecular Health Center LLC
Roumiantsev S.A.
Pirogov Russian National Research Medical University;
Molecular Health Center LLC
The role of tryptophan metabolites in metabolism and pathogenesis of obesity
Journal: Russian Journal of Preventive Medicine. 2022;25(10): 97‑103
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To cite this article:
Shatova OP, Zabolotneva AA, Mikin IE, Bril DV, Shestopalov AV, Roumiantsev SA. The role of tryptophan metabolites in metabolism and pathogenesis of obesity. Russian Journal of Preventive Medicine.
2022;25(10):97‑103. (In Russ.)
https://doi.org/10.17116/profmed20222510197
For humans, the amino acid tryptophan is essential and highly sought after. In addition to participating in protein synthesis, tryptophan undergoes conversion to tryptamine and indole metabolites by enzymes of the gut microbiota. In human cells, tryptophan is utilized through the kynurenine pathway and is converted into the biogenic amine serotonin. Indole-3-acetate and indole-3-propionate are of great importance for the regulation of lipid synthesis. These metabolites inhibit lipogenesis and prevent the development of non-alcoholic fatty liver disease, which is often a concomitant condition in obesity. Indole and serotonin have anorexigenic effects. Indole-3-lactate has a pronounced neurotropic effect. It was found that obesity is associated with a characteristic phenotype of intestinal dysbiosis. Taxonomic and metabolic changes in the gut microbiota result in impaired tryptophan synthesis and altered levels of its metabolites in the body. Obese patients are characterized by decreased plasma tryptophan levels. Proper dietary adjustments, pro-, pre-, symbiotics, and tryptophan supplements can contribute to obesity prevention and treatment.
Keywords:
Authors:
Shatova O.P.
Pirogov Russian National Research Medical University
Zabolotneva A.A.
Pirogov Russian National Research Medical University
Mikin I.E.
All-Russian Non-Governmental Organization of Small and Medium Business «Opora Russia»
Bril D.V.
International Association of Research, Environmental, Medical and Educational Organizations, Producers and Consumers of Goods and Services in the Field of Public Health and Active Longevity «Quality of Life»
Shestopalov A.V.
Pirogov Russian National Research Medical University;
Molecular Health Center LLC
Roumiantsev S.A.
Pirogov Russian National Research Medical University;
Molecular Health Center LLC
Received:
24.01.2022
Accepted:
11.07.2022
List of references:
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