The article describes a clinical case of death of a 57-year-old patient from idiopathic AL-amyloidosis after infection with SARS-CoV-2. Histological examination revealed signs of pneumonia with symptoms of pneumosclerosis, histologically determined diapedesic hemorrhages, necrosis and desquamation of the alveolar epithelium, along the contours of the alveolar passages, alveolar sacs — hyaline membranes. In many areas, the histoarchitectonics of the pulmonary parenchyma was sharply disturbed, connective tissue was determined in the alveolar passages, in the lumens of the alveoli. The interalveolar septa were thickened due to the proliferation of connective tissue. Positive Congo red staining was visualized mainly in the perivascular and interalveolar septa, along the vessels; in the heart — between cardiomyocytes, in the kidneys — in the capillary loops of the glomeruli, basement membranes of individual tubules of the cortical layer, in the walls of blood vessels. Thus, the cause of death of the patient was the severe course of infection with SARS-CoV-2; the presence of a concomitant disease in the form of idiopathic AL-amyloidosis of internal organs and chronic diseases, obviously, aggravated the patient’s condition and contributed to the onset of death.