Skin cancer is one of the most common forms of cancer worldwide, and today, according to the World Health Organization, every third cancer diagnosis is skin pathology. The methods used to diagnose skin neoplasms can be conditionally divided into clinical, instrumental (non-invasive) and morphological (invasive and semi-invasive). Skin cancer is difficult to diagnose accurately and at the same time non-invasively, since malignant neoplasms can easily mimic a benign pathology. In this regard, a biopsy and the subsequent classical pathology-morphological method (if necessary, in combination with additional immuno-histochemical, molecular genetic studies) remain the generally accepted standard of diagnosis and its confirmation in relation to the so-called «suspicious» skin neoplasms. However, histological examination is almost always associated with high cost, significant trauma to the skin and the need for subsequent aesthetic correction of scar tissue, especially in cosmetically significant areas. This review summarizes information on modern non-invasive skin neoplasms diagnostics and the possibility of their practical implementation in order to provide timely medical care.