The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Makhachev D.R.

N.I. Pirogov Russian National Research Medical University

Aliyeva T.A.

N.I. Pirogov Russian National Research Medical University

Bulanov D.V.

N.I. Pirogov Russian National Research Medical University

Volchenko N.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Centre

Algorithms for morphological diagnostics of dysplastic nevus

Authors:

Makhachev D.R., Aliyeva T.A., Bulanov D.V., Volchenko N.N.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2025;14(2): 83‑88

DOI: 10.17116/onkolog20251402183

Read: 667 times

Buy for 300₽
Contact the author
Table of contents

ALGORITHMS FOR MORPHOLOGICAL DIAGNOSTICS OF DYSPLASTIC NEVUS
ALGORITHMS FOR MORPHOLOGICAL DIAGNOSTICS OF DYSPLASTIC NEVUS

To cite this article:

Makhachev DR, Aliyeva TA, Bulanov DV, Volchenko NN. Algorithms for morphological diagnostics of dysplastic nevus. P.A. Herzen Journal of Oncology. 2025;14(2):83‑88. (In Russ.)
https://doi.org/10.17116/onkolog20251402183

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Expe­rience of surgical treatment of patients with meta­stases of mela­noma to the popliteal lymph nodes. P.A. Herzen Journal of Onco­logy. 2025;(2):47-51
Non-invasive auto­mated methods for the diagnosis of periorbital skin tumors. Russian Annals of Ophthalmology. 2024;(5):137-145
Clinical Case of Tattoo Pigment Dete­ction in Sentinel Lymph Nodes Against the Background of Mela­noma. Russian Journal of Clinical Dermatology and Vene­reology. 2024;(6):679-683
Evaluation of the impact of a comprehensive reha­bilitation program on improving nutritional status, psychoemotional signs and adve­rse events in patients with mela­noma after surgical treatment. Piro­gov Russian Journal of Surgery. 2024;(12-2):173-178
Clinical and dermoscopic analysis of atypical sebo­rrheic kera­tosis. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(1):64-71
Orga­nization and payment for mole­cular gene­tic analysis in patients with certain mali­gnancies in the constituent enti­ties of the Russian Fede­ration. Medi­cal Technologies. Asse­ssment and Choice. 2025;(1):36-50
Lung tube­rculosis and mali­gnant neoplasms: the current state of the problem. Russian Journal of Preventive Medi­cine. 2025;(3):122-127
Mela­noma of the maxi­llary sinus mucosa. Stomatology. 2025;(2):82-85
The stru­cture of causes of death of the adult popu­lation of the Moscow region in 2019 and 2023. Russian Journal of Archive of Pathology. 2025;(3):40-48
Abstract:

Dysplastic nevus is a melanocytic skin lesion that, having certain morphological and biological characteristics, can transform into melanoma, one of the most aggressive forms of malignant skin tumors. Timely and accurate diagnosis of dysplastic nevus is the most important element of effective melanoma prevention. The key problem is that traditional morphological and immunohistochemical methods of research, although widely used, are often characterized by limited specificity and sensitivity, which complicates the accurate differential diagnosis of dysplastic nevus from skin melanoma.

Keywords:

dysplastic nevus
melanoma
Duke criteria
malignant neoplasms

Authors:

Makhachev D.R.

N.I. Pirogov Russian National Research Medical University

Aliyeva T.A.

N.I. Pirogov Russian National Research Medical University

Bulanov D.V.

N.I. Pirogov Russian National Research Medical University

Volchenko N.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Centre

Received:

19.10.2024

Accepted:

15.11.2024

Close metadata

References:

  1. Artem’eva NG, Romanova OA. Ekstsizionnaya biopsiya displasticheskogo nevusa v usloviyakh raionnoi polikliniki — put’ k rannemu vyyavleniyu melanomy kozhi. Ambulatornaya Khirurgiya. 2020;(3-4):66-72. (In Russ.). https://doi.org/10.21518/1995-1477-2020-3-4-66-72
  2. Romanova OA, Artem’eva NG, Solokhina MG, Marycheva VN, Veshchevailov AA, Kupchikov SA. Clinical and morphological parallels in the diagnosis of progressive dysplastic nevus and early melanoma. P.A. Herzen Journal of Oncology. 2019;8(1):26-31. (In Russ.). https://doi.org/10.17116/onkolog2019801126
  3. Xavier-Junior JCC, Ocanha-Xavier JP. Dysplastic melanocytic nevus: are molecular findings the key to the diagnosis? Ann Diagn Pathol. 2022;60:152006. https://doi.org/10.1016/j.anndiagpath.2022.152006
  4. Mesbah Ardakani N. Dysplastic/Clark naevus in the era of molecular pathology. Australas J Dermatol. 2019;60(3):186-191.  https://doi.org/10.1111/ajd.13019
  5. Sergeev YuYu, Sergeev VYu, Mordovtseva VV. Follow-up of melano-cytic lesions with use of dermoscopy (literature review). Medical Alphabet. 2020;(6):66-71. (In Russ.). https://doi.org/10.33667/2078-5631-2020-6-66-71
  6. Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, Orringer JS. eds. Fitzpatrick’s dermatology. 9th ed. 2 vol. McGraw-Hill Education; 2019.
  7. Clabbers JMK, Van Doorn R, Kukutsch NA. Turner syndrome, atypical naevi and multiple melanoma: coincidence or causality? Acta Derm Venereol. 2023;103:adv5586. https://doi.org/10.2340/actadv.v103.5586
  8. Romanova OA, Artem’eva NG, Sotnikova YuA. Vyyavlenie progressiruyushchego displasticheskogo nevusa vrachom pervichnogo zvena — put’ k profilaktike i rannei diagnostike melanomy kozhi. Vrach. 2020;(12):37-40. (In Russ.). https://doi.org/10.29296/25877305-2020-12-08
  9. Pil’kevich O, Loboda VN, Dimov I, Popova Yu, Mel’tsova A. Aktualnost’ khirurgicheskogo udaleniya nevusov v ambulatornoi praktike. Mezhdunarodnyi Nauchno-Issledovatel’skii Zhurnal. 2024;(1). (In Russ.). https://doi.org/10.23670/IRJ.2024.139.43
  10. Ghanadan A, Yousefi T, Kamyab-Hesari K, Azhari V, Nasimi M. Prevalence and main determinants of BRAF V600E mutation in dysplastic and congenital nevi. Iran J Pathol. 2021;16(1):51-56.  https://doi.org/10.30699/ijp.2020.130968.2451
  11. Conforti C, Zalaudek I. Epidemiology and risk factors of melanoma: a review. Dermatol Pract Concept. 2021;11(Suppl. 1):e2021161S. https://doi.org/10.5826/dpc.11S1a161S
  12. Romanova OA, Artem’eva NG, Marycheva VN, Kurashvili LR. Algoritm rannego vyyavleniya melanomy kozhi v raionnoi poliklinike. Lechashchii Vrach. 2020;(5):22-26. (In Russ.). https://doi.org/10.26295/OS.2020.19.87.004
  13. Kunitsyna AV, Antonova EI, Davidyuk YuN, Koroleva AK, Achilov AB. Geneticheskie korrelyatsii v otsenke mutatsii genov s dobrokachestvennymi obrazovaniyami kozhi i melanomoi (obzor literatury). Sbornik trudov konferentsii. In: Fundamental’nye i prikladnye issledovaniya po prioritetnym napravleniyam bioekologii i biotekhnologii. Materialy V Vserossiiskoi nauchno-prakticheskoi konferentsii s mezhdunarodnym uchastiem. Ul’yanovsk, May 20, 2022. Cheboksary: Sreda; 2022: 52-64.  https://doi.org/10.31483/r-102465
  14. Vakhitova II, Michenko AV, Potekaev NN, Titov KS, Zhukova OV, L’vov AN. The prevalence of risk factors for development of melanoma among dermatological patients. Russian Journal of Clinical Dermatology and Venereology. 2020;19(5):630-636. (In Russ.). https://doi.org/10.17116/klinderma202019051630
  15. Dessinioti C, Befon A, Stratigos AJ. The association of nevus-associated melanoma with common or dysplastic melanocytic nevus: a systematic review and meta-analysis. Cancers (Basel). 2023;15(3):856.  https://doi.org/10.3390/cancers15030856
  16. Sung WW, Chang CH. Nevi, dysplastic nevi, and melanoma: molecular and immune mechanisms involving the progression. Tzu Chi Med J. 2021;34(1):1-7.  https://doi.org/10.4103/tcmj.tcmj_158_20
  17. Zhang Y, Ostrowski SM, Fisher DE. Nevi and melanoma. Hematol Oncol Clin North Am. 2024;38(5):939-952.  https://doi.org/10.1016/j.hoc.2024.05.005
  18. Drakensjö IRT, Hedblad MA, Colón Cervantes E, Girnita A. Nevus-associated lentigo maligna and lentigo maligna melanoma, clinicopathological features. Acta Derm Venereol. 2024;104:adv18381. https://doi.org/10.2340/actadv.v104.18381
  19. Lorbeer FK, Rieser G, Goel A, Wang M, Oh A, Yeh I, Bastian BC, Hockemeyer D. Distinct senescence mechanisms restrain progression of dysplastic nevi. PNAS Nexus. 2024;3(2):pgae041. https://doi.org/10.1093/pnasnexus/pgae041
  20. Plaza KhA, Prieto VG. Pigmentnye obrazovaniya kozhi. Transl. from English by Demidov LV, Bulanov DV. Moscow: Prakticheskaya meditsina; 2022. 456p. (In Russ.).
  21. Potekaev NN, Drapkina OM, Kaprin AD, Michenko AV, Zhukova OV, Novozhilova OL, Rassokhina OI, Romanov DV, Kochetkov MA. Klinicheskaya diagnostika dobrokachestvennykh i zlokachestvennykh novoobrazovanii kozhi. 2019. 72p. (In Russ.).
  22. Timaeva AI, Antonova EI, Kunitsina AV, Achilov AB, Balatsyuk EV. Gistogeneticheskie korrelyatsii nevusov i melanomy (obzor literatury). Sbornik trudov konferentsii. In: Fundamental’nye i prikladnye issledovaniya po prioritetnym napravleniyam bioekologii i biotekhnologii. Materialy V Vserossiiskoi nauchno-prakticheskoi konferentsii s mezhdunarodnym uchastiem. Ul’yanovsk, May 20, 2022. Cheboksary: Sreda; 2022: 152-162. (In Russ.). https://doi.org/10.31483/r-102368
  23. Ferrara G, Argenziano G. The WHO 2018 Classification of Cutaneous Melanocytic Neoplasms: suggestions from routine practice. Front Oncol. 2021;11:675296. https://doi.org/10.3389/fonc.2021.675296
  24. Romanova OA, Artem’eva NG, Marycheva VN, Kurashvili LR. The results of excision of pigmented lesion in patients with a progressive dysplastic nevus. P.A. Herzen Journal of Oncology. 2020;9(6):4550. (In Russ.). https://doi.org/10.17116/onkolog2020906145
  25. Romanova OA, Artem’eva NG, Marycheva VN, Kurashvili LR, Veshchevailov AA. Clinical features of early melanoma developed at the basis of dysplastic nevus. Russian Journal of Clinical Dermatology and Venereology. 2021;20(4):45-49. (In Russ.). https://doi.org/10.17116/klinderma20212004145
  26. Izol Özmen H. Publication trends and hot topics in dysplastic nevus research: a 30-year bibliometric analysis. Dermatol Pract Concept. 2023;13(4):e2023266. https://doi.org/10.5826/dpc.1304a266
  27. Gardner JM. Survival guide to dermatopathology. Innovative Pathology Press; 2020. 298p.
  28. Clark WH Jr, Elder DE, Guerry D 4th, Epstein MN, Greene MH, Van Horn M. A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma. Hum Pathol. 1984;15(12):1147-1165. https://doi.org/10.1016/s0046-8177(84)80310-x
  29. Clemente C, Cochran AJ, Elder DE, Levene A, MacKie RM, Mihm MC, Rilke F, Cascinelli N, Fitzpatrick TB, Sober AJ. Histopathologic diagnosis of dysplastic nevi: concordance among pathologists convened by the World Health Organization Melanoma Programme. Hum Pathol. 1991;22(4):313- 319.  https://doi.org/10.1016/0046-8177(91)90078-4
  30. Arumi-Uria M, McNutt NS, Finnerty B. Grading of atypia in nevi: correlation with melanoma risk. Mod Pathol. 2003;16(8):764-771.  https://doi.org/10.1097/01.MP.0000082394.91761.E5
  31. Popecki P, Jurczyszyn K, Ziętek M, Kozakiewicz M. Texture analysis in diagnosing skin pigmented lesions in normal and polarized light — a preliminary report. J Clin Med. 2022;11(9):2505. https://doi.org/10.3390/jcm11092505
  32. Fraga-Braghiroli N, Grant-Kels JM, Oliviero M, Rabinovitz H, Ferenczi K, Scope A. The role of reflectance confocal microscopy in differentiating melanoma in situ from dysplastic nevi with severe atypia: a cross- sectional study. J Am Acad Dermatol. 2020;83(4):1035-1043. https://doi.org/10.1016/j.jaad.2020.05.071
  33. Moscarella E, Guitera P, Scolyer RA, Rocha L, Thomas L, Ronchi A, Scharf C, Brancaccio G, Argenziano G. Junctional nevus and early melanoma on sun-damaged skin of the head/neck: a clinico-pathologic challenge. Dermatol Pract Concept. 2023;13(2):e2023122. https://doi.org/10.5826/dpc.1302a122
  34. Maillard M, Stucki L, Kaya G. A case of compound nevus with intradermal pseudoglandular features: a rare variant and possible pitfall. Dermatopathology. 2019;6(2):41-44.  https://doi.org/10.1159/000500400
  35. Ranawaka RR. Congenital naevi and melanocytic naevi. In: Ranawaka RR, Kannangara AP, Karawita A, eds. Atlas of dermatoses in pigmented skin. Springer Singapore; 2021: 45-64.  https://doi.org/10.1007/978-981-15-5483-4_2
  36. Bryant D. ISID0851 — RNA therapy for congenital melanocytic naevi. 2023. https://doi.org/10.26226/m.641999f8b9b42e0013e59344
  37. Cimmino A, Cazzato G, Colagrande A, Maiorano E, Lospalluti L, Ingravallo G, Resta L. Spitz nevus with features of clark nevus, so-called SPARK nevus: case series presentation with emphasis on cytological and histological features. Dermatopathology (Basel). 2021;8(4):525-530.  https://doi.org/10.3390/dermatopathology8040055
  38. Popa LG, Giurcaneanu C, Nitipir C, Popa AM, Stoica C, Beiu C, Tebeica T, Negoita S, Mihai MM. Dysplastic nevus syndrome and pancreatic cancer: a case report. Exp Ther Med. 2022;23(1):31.  https://doi.org/10.3892/etm.2021.10953
  39. Torreyes-Reyes M, Lascano N, Barzallo J, Lafuento L. Nevu agminado en síndrome de nevus displásico. Rev Dig Postgrado. 2021;10(2):e287. https://doi.org/10.37910/rdp.2021.10.2.e287
  40. Aydin Ulgen O, Yıldız P, Acar HC, Demirkesen C. Analysis of interobserver reproducibility in grading dysplastic nevi: results of the application of the 2018 World Health Organization Grading Criteria. J Cutan Pathol. 2022;49(4):343-349.  https://doi.org/10.1111/cup.14165
  41. Braun-Falco M. Disorders of keratinization. In: Plewig G, French L, Ruzicka T, Kaufman R, Hertl M, eds. Braun-Falco ́s dermatology. 4th ed. 2022: 1073-1095. https://doi.org/10.1007/978-3-662-63709-8_61
  42. Ensslin CJ, Hibler BP, Lee EH, Nehal KS, Busam KJ, Rossi AM. Atypical melanocytic proliferations: a review of the literature. Dermatol Surg. 2018;44(2):159-174.  https://doi.org/10.1097/DSS.0000000000001367
  43. Popecki P, Jurczyszyn K, Ziętek M, Kozakiewicz M. Texture analysis in diagnosing skin pigmented lesions in normal and polarized light — a preliminary report. J Clin Med. 2022;11(9):2505. https://doi.org/10.3390/jcm11092505
  44. Xavier-Júnior JC, Ocana-Xavier JP, Camilo-Junior DJ, Garcia Pires D’avilla SC, Mattar NJ. Interesting overlooked findings in melanocytic nevi. Surg Exp Pathol. 2019;2(1):19.  https://doi.org/10.1186/s42047-019-0044-9
  45. Maher N, Qiu M. 19. Examining discordance between histopathology diagnoses of thin melanoma compared to dysplastic naevi. Pathology. 2019;51:S153. https://doi.org/10.1016/j.pathol.2018.09.019
  46. Shea CR, Vollmer RT, Prieto VG. Correlating architectural disorder and cytologic atypia in Clark (dysplastic) melanocytic nevi. Hum Pathol. 1999;30(5):500-505.  https://doi.org/10.1016/s0046-8177(99)90191-0
  47. Di Brizzi EV, Pampena R, Licata G, Calabrese G, Longo C, Argenziano G. Are we born and do we die without nevi? A cross-sectional study. Int J Dermatol. 2021;60(11):1405-1410. https://doi.org/10.1111/ijd.15668
  48. Kossard S, Commens C, Symons M, Doyle J. Lentinginous dysplastic naevi in the elderly: a potential precursor for malignant melanoma. Australas J Dermatol. 1991;32(1):27-37.  https://doi.org/10.1111/j.1440-0960.1991.tb00679.x
  49. Boyd AS, Chen SC, Shyr Y. Intradermal nevi with atypical nuclei in the elderly: the senescent nevus. J Am Acad Dermatol. 2015;73(3):500-506.  https://doi.org/10.1016/j.jaad.2015.06.013
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.