The results obtained from the study of the physical activity and working capacity of a Tyumen unorganized population with and without coronary heart disease (CHD) can serve as a scientific basis for planning comprehensive socially oriented programs for the prevention of cardiovascular diseases in the region and in other medium Siberian towns. Objective. To define associations between low physical activity and working capacity in an open urban population with and without CHD. Methods. The investigation was conducted within the cardiology screening of an open urban male and female population aged 25—64 years. A representative sample was formed from the electoral rolls of one of the administrative districts of Tyumen. Different forms of CHD were identified by standard epidemiological methods. WHO MONICA-psychosocial questionnaire was used to assess physical activity. Results. There were decreases in physical activity and working capacity in the male groups with CHD as both definite and possible forms. The men having definite forms of CHD and the latter defined by the extended epidemiological criteria versus other age-matched people negatively assessed their physical activity. Reduced working capacity and physically passive leisure were found in the female groups with definite forms of CHD and the latter defined by the extended epidemiological criteria; and the group with the definite forms of CHD negatively assessed their physical activity compared with other age-matched people. Conclusion. The investigation showed that the priority orientation for increasing physical activity and working capacity should be directed to the needs of risk groups, such as men and women with definite and possible CHD and the latter defined by the extended epidemiological criteria.