The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Matchekhina L.V.

Endocrinology Research Centre, Moscow, Russian Federation

Dudinskaya E.N.

National Research Centre for Preventive Medicine, Moscow, Russia

Tkacheva O.N.

Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia

Vitamin D deficiency in elderly people with senile asthenia

Authors:

Matchekhina L.V., Dudinskaya E.N., Tkacheva O.N.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2019;22(5): 118‑124

Read: 40284 times


To cite this article:

Matchekhina LV, Dudinskaya EN, Tkacheva ON. Vitamin D deficiency in elderly people with senile asthenia. Russian Journal of Preventive Medicine. 2019;22(5):118‑124. (In Russ.)
https://doi.org/10.17116/profmed201922051118

Recommended articles:
Vita­min B12 defi­ciency in the elde­rly and its asso­ciations with geriatric syndromes. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):41-47
Vita­min D role in oral cavity diseases. Stomatology. 2025;(1):81-86
Economics of hype­rparathyroidism. Part 2 — seco­ndary hype­rparathyroidism. Medi­cal Technologies. Asse­ssment and Choice. 2025;(3):74-82

References:

  1. Rockwood K, Stadnyk K, MacKnight C, McDowell I, Hebert R, Hogan DB. A brief clinical instrument to classify frailty in elderly people. Lancet. 1999;353(9148):205-206. https://doi.org/10.1016/S0140-6736(98)04402-X
  2. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA. Frailty in older adults: evidence for a phenotype. Cardiovascular Health Study Collaborative Research Group. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146-M156.
  3. Tkacheva ON, Runikhina NK, Ostapenko VS, Sharashkina NV, Mkhitaryan EA, Onuchina YuS, Lysenkov SN. Validation of the questionnaire for screening senile asthenia syndrome in outpatient practice. Successes of gerontology. 2017;30(2):236-242. (In Russ.)
  4. Collard RM, Boter H, Schoevers RA, Oude Voshaar RC. Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc. 2002;60(8):1487-1492. https://doi.org/10.1111/j.1532-5415.2012.04054.x
  5. Bock JO, Konig HH, Brenner H, Haefeli WE, Quinzler R, Matschinger H, Saum KU, Schottker B, Heider D. Associations of frailty with health care costs–results of the ESTHER cohort study. BMC Health Serv Res. 2016;16:128. https://doi.org/10.1186/s12913-016-1360-3
  6. Sharashkina NV, Runikhina NK, Tkacheva ON, Ostapenko VS, Dudinskaya EN. Prevalence, diagnostic methods and correction of sarcopenia in the elderly. Clinical gerontology. 2016;22(3-4):46-51. (In Russ.)
  7. Girgis CM, Clifton-Bligh RJ, Hamrick MW, Holick MF, Gunton JE. The roles of vitamin D in skeletal muscle: Form, function, and metabolism. Endocrine Reviews. 2013;34(1):33-83. https://doi.org/10.1210/er.2012-1012
  8. Welch AA. Nutritional influences on age-related skeletal muscle loss. Proc Nutr Soc. 2014;73(01):16-33.
  9. Gunton JE, Girgis CM, Baldock PA, Lips P. Bone muscle interactions and vitamin D. Bone. 2015;80:89-94.
  10. Vaes Anouk MM, Brolsma EM, Toussaint N, de Regt M, Tieland M, van Loon LJ. The association between 25-hydroxyvitamin D concentration, physical performance and frailty status in older adults. European Journal of Nutrition. 2018. https://doi.org/10.1007/s00394-018-1634-0
  11. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM. Sarcopenia: European consensus on definition and diagnosis: Report of the European working group on sarcopenia in older people. Age Ageing. 2010;39:412-423. https://doi.org/10.1093/ageing/afq034
  12. Morley JE, Baumgartner RN, Roubenoff R, Mayer J, Nair KS. Sarcopenia. J Lab Clin Med. 2001;137:231-243. https://doi.org/10.1067/mlc.2001.113504
  13. Morley JE. Diabetes, sarcopenia, and frailty. Clin Geriatr Med. 2008;24:455-469.
  14. Tessier AJ, Chevalier S. An Update on Protein, Leucine, Omega-3 Fatty Acids and Vitamin D in the Prevention and Treatment of Sarcopenia and Functional Decline. Nutrients. 2018;10(8):1099. https://doi.org/10.3390/nu10081099
  15. Delmonico MJ, Harris TB, Lee JS, Visser M, Nevitt M, Kritchevsky SB, Tylavsky FA, Newman AB. Health, Aging and Body Composition Study. Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. J Am Geriatr Soc. 2007;55:769-774.
  16. Landi F, Cruz-Jentoft AJ, Liperoti R, Russo A, Giovannini S, Tosato M, Capoluongo E, Bernabei R, Onder G. Sarcopenia and mortality risk in frail older persons aged 80 years and older: Results from ilsirente study. Age Ageing. 2013;42:203-209.
  17. Bollwein J, Volkert D, Diekmann R, Kaiser MJ, Uter W, Vidal K, Sieber CC, Bauer JM. Nutritional status according to the mini nutritional assessment (mna(r)) and frailty in community dwelling older persons: A close relationship. J Nutr Health Aging. 2013;17:351-356.
  18. Dorner TE, Luger E, Tschinderle J, Stein KV, Haider S, Kapan A, Lackinger C, Schindler KE. Association between nutritional status (mna(r)-sf) and frailty (share-fi) in acute hospitalised elderly patients. J Nutr Health Aging. 2014;18:264-269.
  19. Chevalier S, Saoud F, Gray-Donald K, Morais JA. The physical functional capacity of frail elderly persons undergoing ambulatory rehabilitation is related to their nutritional status. J Nutr Health Aging. 2008;12:721-726.
  20. Tkacheva ON, Runikhina NK, Kotovskaya YuV, Sychev DA, Dudinskaya EN, Mkhitaryan EA, Sharashkina NV, Ostapenko VS, Kashtanova DA. Maintaining patients with senile asthenia in primary care. Study Guide for Doctors. Moscow. 2016. (In Russ.)
  21. Egshatyan LV, Dudinskaya EN, Tkacheva ON, Kashtanova DA. The Role of Vitamin D In the Pathogenesis of Chronic Non-Communicable Diseases. Osteoporosis and osteopathy. 2014;3:27-30. (In Russ.).
  22. Gallagher JC. Vitamin D and aging. Endocrinol Metab Clin North Am. 2013;42:319-332.
  23. Hilger J, Friedel A, Herr R, Rausch T, Roos F, Wahl DA, et al: A systematic review of vitamin D status in populations worldwide. Br J Nutr. 2014;111:23-45.
  24. Geriatrics: National Guide. Ed. Tkacheva HE, Frolova EV, Yahno NN. M.: GEOTAR-Media, 608. (In Russ.)
  25. Meehan M, Penckofer S. The role of vitamin D in the aging adult. J Aging Gerontol. 2014;2:60-71.
  26. Skaaby T, Thuesen BH, Linneberg A. Vitamin D, Sarcopenia and Aging Front Horm Res. Basel (Karger), 2018;50:177-188. https://doi.org/10.1159/000486084
  27. Kühn J, Trotz P, Stangl GI. Z Gerontol Geriat. 2018;51:567. https://doi.org/10.1007/s00391-018-1390-z
  28. Menant J, Close J, Delbaere K, Sturnieks D, Trollor J, Sachdev P, Brodaty H, Lord S. Relationships between serum vitamin D levels, neuromuscular and neuropsychological function and falls in older men and women. Osteoporos Int. 2012;23(3):981-989.
  29. Bolzetta F, Stubbs B, Noale M, Vaona A, Demurtas J, Celotto S, Cester A, Maggi S, Koyanagi A, Cereda E, Veronese N. Low-dose vitamin D supplementation and incident frailty in older people: an eight year longitudinal study. Exp Gerontol. 2018 Jan;101:1-6. https://doi.org/10.1016/j.exger.2017.11.007
  30. Halfon M, Phan O, Teta D. Vitamin D: A Review on Its Effects on Muscle Strength, the Risk of Fall, and Frailty. BioMed Research International. 2015;2015Article ID 953241):11. https://doi.org/10.1155/2015/953241
  31. Kojima G, Iliffe S, Tanabe M. Vitamin D supplementation as a potential cause of U-shaped associations between vitamin D levels and negative healthoutcomes: a decision tree analysis for risk of frailty. Geriatrics. 2017;17:236. https://doi.org/10.1186/s12877-017-0631-0
  32. Zittermann A, Iodice S, Pilz S, Grant WB, Bagnardi V, Gandini S. Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies. Am J Clin Nutr. 2012;95(1):91-100.
  33. Grant WB. Critique of the U-shaped serum 25-hydroxyvitamin D leveldisease response relation. Dermatoendocrinol. 2009;1(6):289-293.
  34. Grant WB, Karras SN, Bischoff-Ferrari HA, Annweiler C, Boucher BJ, Juzeniene A, Garland CF, Holick MF. Do studies reporting ‘U’-shaped serum 25- hydroxyvitamin D-health outcome relationships reflect adverse effects? Dermatoendocrinol. 2016;8(1):e1187349.
  35. Sempos CT, Durazo-Arvizu RA, Dawson-Hughes B, Yetley EA, Looker AC, Schleicher RL, Cao G, Burt V, Kramer H, Bailey RL, et al. Is there a reverse Jshaped association between 25-hydroxyvitamin D and all-cause mortality? Results from the U.S. nationally representative NHANES. J Clin Endocrinol Metab. 2013;98(7):3001-3009.
  36. Zittermann A, Prokop S, Gummert JF, Borgermann J. Safety issues of vitamin D supplementation. Anti Cancer Agents Med Chem. 2013;13(1):4-10.
  37. Granic A, Aspray T, Hill T, Davies K, Collerton J, Martin-Ruiz C, von Zglinicki T, Kirkwood TB, Mathers JC, Jagger C. 25-hydroxyvitamin D and increased allcause mortality in very old women: the Newcastle 85+ study. J Intern Med. 2015;277(4):456-467.
  38. Kojima G. Prevalence of frailty in nursing homes: a systematic review and metaanalysis. J Am Med Dir Assoc. 2015;16(11):940-945.
  39. Sang Yhun Ju, June Young Lee, Do Hoon Kim. Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response metaanalysis. BMC Geriatrics, 2018, 206, https://doi.org/10.1186/s12877-018-0904-2.
  40. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84(1):18-28.
  41. Vogt S, Decke S, de Las Heras Gala T, Linkohr B, Koenig W, Ladwig KH, Peters A, Thorand B. Prospective association of vitamin D with frailty status and all-cause mortality in older adults: results from the KORA-age study. Prev Med. 2015;73:40-46.
  42. Barger-Lux MJ, Heaney RP, Dowell S, Chen TC, Holick MF. Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men. Osteoporosis Int. 1998;8(3):222-230.
  43. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77(1):204-210.
  44. Lehmann U, Riedel A, Hirche F, Brandsch C, Girndt M, Ulrich C, Seibert E, Henning C, Glomb MA, Dierkes J, et al. Vitamin D3 supplementation: Response and predictors of vitamin D3 metabolites — a randomized controlled trial. Clin Nutr. 2016;35(2):351-358.
  45. Sousa-Santos AR, Afonso C, Santos A, Borges N, Moreira P, Padrão P, et al. The association between 25(OH) D levels, frailty status and obesity indices in older adults. J Frailty Aging. 2017;7(2):43-46.
  46. Pereira-Santos M, Costa PRF, Assis AMO, Santos CAST, Santos DB. Obesity and vitamin D deficiency: a systematic review and metaanalysis. Obes Rev. 2015;16:341-349. https://doi.org/10.1111/obr.12239 PMID: 25688659
  47. Saneei P, Salehi-Abargouei A, Esmaillzadeh A. Serum 25-hydroxy vitamin D levels in relation to body mass index: a systematic review and metaanalysis. Obes Rev. 2013;14:393-404. https://doi.org/10.1111/obr.12016 PMID: 23331724
  48. McGill A-T, Stewart JM, Lithander FE, Strik CM, Poppitt SD. Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity. Nutr J BioMed Central. 2008;7:4. https://doi.org/10.1186/1475-2891-7-4 PMID: 18226257
  49. Snijder MB, van Dam RM, Visser M, Deeg DJH, Dekker JM, Bouter LM, et al. Adiposity in Relation to Vitamin D Status and Parathyroid Hormone Levels: A Population-Based Study in Older Men and Women. J Clin Endocrinol Metab. 2005;90:4119-4123. https://doi.org/10.1210/jc.2005-0216 PMID: 15855256
  50. Pourhassan M, Wirth R. Seasonal Variation in Vitamin D Status among Frail Older Hospitalized Patients. J Frailty Aging. 2018;7(2):95-99. https://doi.org/10.14283/jfa.2018.10
  51. Sjors Verlaan, et al. Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults The PROVIDE study Clinical Nutrition. 2018;(37):e551-e557.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.