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Tkacheva O.N.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia

Runikhina N.K.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia

Cherdak M.A.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia

Sharashkina N.V.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia

Lysenkov S.N.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia;
M.V. Lomonosov Moscow State University, Moscow, Russia

Mkhitaryan E.A.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia

Arefyeva M.S.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia

Popov E.E.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia

Influence of cognitive status on the effectiveness of geriatric rehabilitation: Data from the POSTSCRIPTUM study

Authors:

Tkacheva O.N., Runikhina N.K., Cherdak M.A., Sharashkina N.V., Lysenkov S.N., Mkhitaryan E.A., Arefyeva M.S., Popov E.E.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(4‑2): 13‑22

DOI: 10.17116/jnevro202612604213

Read: 388 times

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Table of contents

INFLUENCE OF COGNITIVE STATUS ON THE EFFECTIVENESS OF GERIATRIC REHABILITATION: DATA FROM THE POSTSCRIPTUM STUDY
INFLUENCE OF COGNITIVE STATUS ON THE EFFECTIVENESS OF GERIATRIC REHABILITATION: DATA FROM THE POSTSCRIPTUM STUDY

To cite this article:

Tkacheva ON, Runikhina NK, Cherdak MA, et al. Influence of cognitive status on the effectiveness of geriatric rehabilitation: Data from the POSTSCRIPTUM study. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(4‑2):13‑22. (In Russ.)
https://doi.org/10.17116/jnevro202612604213

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the influence of baseline cognitive status on the outcomes of geriatric rehabilitation in patients with different geriatric statuses, including patients with «cognitive frailty» syndrome.

MATERIAL AND METHODS

Subanalysis of a multicenter prospective POSTSCRIPTUM study evaluating the efficacy of 21-day geriatric rehabilitation programs based on the results of a comprehensive geriatric assessment (CGA) in patients 60 years of age and older. Based on CGA results, groups with the senile asthenia (AS) and preasthenia were identified; with a combination of cognitive impairment and AS, the «cognitive frailty» was diagnosed.

RESULTS

The analysis included 483 patients; AS syndrome was present in 35% of patients, and preasthenia was present in 60%. Mild cognitive impairment was diagnosed in 307 patients (64%); «cognitive frailty» syndrome was present in 125 subjects. Patients with cognitive impairment had poorer somatic status and a greater burden of cardiovascular diseases at baseline. The presence of cognitive impairment was associated with a poorer functional status even in the absence of dementia syndrome. The intervention resulted in a significant improvement in the geriatric status in all groups, including those with «cognitive frailty».

CONCLUSION

Cognitive impairment is an important factor affecting the functional status of elderly patients. A 3-week multicomponent geriatric intervention improved functional, physical, and cognitive status, supporting further study to evaluate its potential to prevent dementia and optimize geriatric patient management.

Keywords:

geriatric rehabilitation
senile asthenia
cognitive impairment
cognitive frailty
old age
comprehensive geriatric assessment

Authors:

Tkacheva O.N.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia

Runikhina N.K.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia

Cherdak M.A.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia

Sharashkina N.V.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia

Lysenkov S.N.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia;
M.V. Lomonosov Moscow State University, Moscow, Russia

Mkhitaryan E.A.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia

Arefyeva M.S.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia

Popov E.E.

Pirogov Russian National Research Medical University — Russian Gerontology Research and Clinical Centre, Moscow, Russia

Received:

13.01.2026

Accepted:

15.01.2026

Close metadata

References:

  1. Cherdak MA, Mkhitaryan EA, Sharashkina NV, et al. Prevalence of cognitive impairment in older adults in the Russian Federation. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4-2):5-11. (In Russ.). https://doi.org/10.17116/jnevro20241240425
  2. Sugimoto T, Arai H, Sakurai T. An update on cognitive frailty: Its definition, impact, associated factors and underlying mechanisms, and interventions. Geriatr Gerontol Int. 2022;22(2):99-109.  https://doi.org/10.1111/ggi.14322
  3. Pavasini R, Guralnik J, Brown JC, et al. Short Physical Performance Battery and all-cause mortality: systematic review and meta-analysis. BMC Med. 2016;14(1):215.  https://doi.org/10.1186/s12916-016-0763-7
  4. Wong EKC, Hoang PM, Kouri A, et al. Effectiveness of geriatric rehabilitation in inpatient and day hospital settings: a systematic review and meta-analysis. BMC Med. 2024;22(1):551.  https://doi.org/10.1186/s12916-024-03764-7
  5. Tkacheva ON, Runikhina NK, Malaya IP, et al. POSTSCRIPTUM: Protocol of Geriatric Rehabilitation in Patients Aged 60 Years and Older Living in Moscow Boarding houses or Nursing homes. Protocol of Multicentral Prospective Study. Russian Journal of Geriatric Medicine. 2023;1(13):54-62. (In Russ.). https://doi.org/10.37586/2686-8636-1-2023-54-62
  6. Tkacheva ON, Runikhina NK, Malaya IP, et al. Effectiveness of three-week rehabilitation programs in improving mobility of patients with frailty syndrome: a subgroup analysis of the multicenter prospective study «POSTSCRIPTUM». Russian Journal of Geriatric Medicine. 2024;4(20):254-262. (In Russ.). https://doi.org/10.37586/2686-8636-4-2024-254-262
  7. Tkacheva ON, Runikhina NK, Malaya IP, et al. Geriatric Rehabilitation in Patients with Frailty: Interim Results of the POSTSCRIPTUM. An Open Prospective Study. Bulletin of Rehabilitation Medicine. 2024;23(6):8-18. (In Russ.). https://doi.org/10.38025/2078-1962-2024-23-6-8-18
  8. Cherdak MA. Mechanisms of Neurocognitive Adaptation during Aging Process. Adv Gerontol. 2023;13:123-129.  https://doi.org/10.1134/S2079057024600204
  9. Livingston G, Huntley J, Liu KY, et al. Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. Lancet. 2024;404(10452):572-628.  https://doi.org/10.1016/S0140-6736(24)01296-0
  10. Isaev RI, Tkacheva ON, Runikhina NK, et al. Management of older and senile patients with a high risk of delirium when providing inpatient care. Clinical protocol. Russian Journal of Geriatric Medicine. 2022;(1):17-23. (In Russ.). https://doi.org/10.37586/2686-8636-1-2022-17-23
  11. Wallace LMK, Theou O, Darvesh S, et al. Neuropathologic burden and the degree of frailty in relation to global cognition and dementia. Neurology. 2020;95(24):e3269-e3279. https://doi.org/10.1212/WNL.0000000000010944
  12. Petermann-Rocha F, Lyall DM, Gray SR, et al. Associations between physical frailty and dementia incidence: a prospective study from UK Biobank. Lancet Healthy Longev. 2020;1(2):e58-e68.  https://doi.org/10.1016/S2666-7568(20)30007-6
  13. Fang J, Liang H, Chen M, et al. Association of preoperative cognitive frailty with postoperative complications in older patients under general anesthesia: a prospective cohort study. BMC Geriatr. 2024;24(1):851.  https://doi.org/10.1186/s12877-024-05431-1
  14. Imahori Y, Vetrano DL, Ljungman P, et al. Association of ischemic heart disease with long-term risk of cognitive decline and dementia: A cohort study. Alzheimers Dement. 2023;19(12):5541-5549. https://doi.org/10.1002/alz.13114
  15. Deckers K, Schievink SHJ, Rodriquez MMF, et al. Coronary heart disease and risk for cognitive impairment or dementia: Systematic review and meta-analysis. PLoS One. 2017;12(9):e0184244. https://doi.org/10.1371/journal.pone.0184244
  16. Filler J, Georgakis MK, Dichgans M. Risk factors for cognitive impairment and dementia after stroke: a systematic review and meta-analysis. Lancet Healthy Longev. 2024;5(1):e31-e44.  https://doi.org/10.1016/S2666-7568(23)00217-9
  17. Warren A. The relationship between perceived stigma and perceived stress in cognitive decline: a survey of persons with mild cognitive impairment and their caregivers. Front Psychol. 2023;14:1293284. https://doi.org/10.3389/fpsyg.2023.1293284
  18. Rosenberg A, Mangialasche F, Ngandu T, et al. Multidomain Interventions to Prevent Cognitive Impairment, Alzheimer’s Disease, and Dementia: From FINGER to World-Wide FINGERS. J Prev Alzheimers Dis. 2020;7(1):29-36.  https://doi.org/10.14283/jpad.2019.41
  19. Li B, Tang H, He G, et al. Tai Chi enhances cognitive training effects on delaying cognitive decline in mild cognitive impairment. Alzheimers Dement. 2023;19(1):136-149.  https://doi.org/10.1002/alz.12658
  20. Dedeyne L, Deschodt M, Verschueren S, et al. Effects of multi-domain interventions in (pre)frail elderly on frailty, functional, and cognitive status: a systematic review. Clin Interv Aging. 2017;12:873-896.  https://doi.org/10.2147/CIA.S130794
  21. Wang S, Li Q, Wang S, et al. Sustained frailty remission and dementia risk in older adults: A longitudinal study. Alzheimers Dement. 2024;20(9):6268-6277. https://doi.org/10.1002/alz.14109
  22. Nguyen L, Murphy K, Andrews G. Immediate and long-term efficacy of executive functions cognitive training in older adults: A systematic review and meta-analysis. Psychol Bull. 2019;145(7):698-733.  https://doi.org/10.1037/bul0000196
  23. Edwards JD, Xu H, Clark DO, et al. Speed of processing training results in lower risk of dementia. Alzheimers Dement (NY). 2017;3(4):603-611.  https://doi.org/10.1016/j.trci.2017.09.002
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