The main approaches to dietary changes in non-alcoholic fatty liver disease

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Nonalcoholic fatty liver disease (NAFLD) is an important cause of chronic liver disease in many countries — a quarter of the world’s population suffers from NAFLD. The incidence of NAFLD is growing rapidly among both adults and children. Proper nutrition and normalization of body weight in such patients — the basis of treatment of the disease. This article presents the main approaches to changing nutrition in people with NAFLD.

Keywords:

non-alcoholic fatty liver disease

hypocaloric diet

fructose

glycemic index

TRANS fats

omega-3-polyunsaturated fatty acids

alcohol

coffee

diet

Authors:

Drapkina O.M.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova, Klinika propedevtiki vnutrennikh bolezneĭ, gastroénterologii i gepatologii

SPIN RSCI: 4456-1297
Scopus AuthorID: 57208852308
ResearcherID: G-8443-2016
ORCID: 0000-0002-4453-8430

Shepel R.N.

National Research Center for Preventive Medicine, Moscow, Russia, 101990

SPIN RSCI: 3115-0515
Scopus AuthorID: 56165734700
ORCID: 0000-0002-8984-9056

Starodubova A.V.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, 2/14, Ustyinsky Passage, Moscow, Russia, 109240;
N.I. Pirogov Russian National Research Medical University, 1, Ostrovityanov St., Moscow, Russia, 117997

Evsutina Yu.V.

National Research Center for Preventive Medicine of the Ministry of Healthcare of the Russia, Moscow, Russia

List of references:

Younossi ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64(1):73-84. https://doi.org/10.1002/hep.28431
Ivashkin VT, Drapkina OM, Mayev IV, et al. Prevalence of non-alcoholic fatty liver disease patients to outpatient practices in the Russian Federation: the results of the study DIREG 2. Russian journal of gastroenterology, Hepatology, Coloproctology. 2015;6:31-41. (In Russ.)
Lazebnik LB, et al. Nonalcoholic fatty liver disease: clinic, diagnosis, treatment (recommendations for therapists, version 2). Therapy. 2017;3(13):6-23. (In Russ.)
Machado M, Cortez-Pinto H. Non-alcoholic steatohepatitis and metabolic syndrome. Curr Opin Clin Nutr Metab Care. 2006;9:6374-6642. https://doi.org/10.1097/01.mco.0000241677.40170.17
Tiikkainen M, Bergholm R, Vehkavaara S, et al. Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content. Diabetes. 2003;52:701-707.
Kechagias S, Ernersson A, Dahlqvist O, et al. Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects. Gut. 2008;57:649-654. https://doi.org/10.1136/gut.2007.131797
Brons C, Jensen C B, Storgaard H, et al. Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men. The Journal of Physiology. 2009;587:2387-2397. https://doi.org/10.1113/jphysiol.2009.169078
van der Meer RW, Hammer S, Lamb HJ, et al. Effects of Short-Term High-Fat, High-Energy Diet on Hepatic and Myocardial Triglyceride Content in Healthy Men. J Clin Endocrinol Metab. 2008;93:2702-2708. https://doi.org/10.1210/jc.2007-2524
Le KA, Ith M, Kreis R, et al. Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. Am J Clin Nutr. 2009;89:1760-1765. https://doi.org/10.3945/ajcn.2008.2733
Anderson GH, Moore SE Dietary proteins in the regulation of food intake and body weight in humans. J Nutr. 2004 ;134(4):974S-979S. https://doi.org/10.1093/jn/134.4.974S
Tremblay F, Lavigne C, Jacques H, Marette A. Role of dietary proteins and amino acids in the pathogenesis of insulin resistance. Annu Rev Nutr. 2007;27:293-310. https://doi.org/10.1146/annurev.nutr.25.050304.092545
Bortolotti M, Kreis R, Debard C, et al. High protein intake reduces intrahepatocellular lipid deposition in humans. Am J Clin Nutr. 2009;90:1002-1010. https://doi.org/10.3945/ajcn.2008.27296
EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. Journal of Hepatology. 2016;64(6):1388-1402. https://doi.org/10.1016/j.jhep.2015.11.004
Peters HPF, Schrauwen P, Verhoef P, et al. Liver fat: a relevant target for dietary intervention? Summary of a Unilever workshop. Journal of Nutritional Science. 2017;6:e15. https://doi.org/10.1017/jns.2017.13
Boden G. High- or low-carbohydrate diets: which is better for weight loss, insulin resistance, and fatty livers? Gastroenterology. 2009;136:1490-1492. https://doi.org/10.1053/j.gastro.2009.03.019
Lin WY, Wu CH, Chu NF, Chang CJ. Efficacy and safety of very-low-calorie diet in Taiwanese: a multicenter randomized, controlled trial. Nutrition. 2009;25(11-12):1129-1136. https://doi.org/10.1016/j.nut.2009.02.008
Ghaemi A, Taleban FA, Hekmatdoost A, et al. How Much Weight Loss is Effective on Nonalcoholic Fatty Liver Disease? Hepatitis Monthly. 2013; 13(12):e15227. https://doi.org/10.5812/hepatmon.15227
Zelber-Sagi S, Lotan R, Shlomai A, et al. Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up. J Hepatol. 2012;56:1145-1151. https://doi.org/10.1016/j.jhep.2011.12.011
Lazo M, Solga SF, Horska A, et al. Effect of a 12-month intensive lifestyle intervention on hepatic steato-sis in adults with type 2 diabetes. Diabetes Care. 2010;33:2156-2163. https://doi.org/10.2337/dc10-0856
Mosca A, Nobili V, De Vito R, et al. Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents. J Hepatol. 2017;66:1031-1036. https://doi.org/10.1016/j.jhep.2016.12.025
Siddiqi Z, Karoli R, Fatima J, et al. Soft Drinks Consumption and the Risk of Nonalcoholic Fatty Liver Disease. J Assoc Phys India. 2017;65:28-32.
Eckel RH. Clinical practice. Nonsurgical management of obesity in adults. N Engl J Med. 2008;358:1941-1950. https://doi.org/10.1056/NEJMcp0801652
Jang EC, Jun DW, Lee SM, et al. Comparison of efficacy of low-carbohydrate and low-fat diet education program in non-alcoholic fatty liver disease; Randomized controlled study. Hepatol Res. 2018;48(3):E22-E29. https://doi.org/10.1111/hepr.12918
Barrera F, George J. The role of diet and nutritional intervention for the management of patients with NAFLD. Clin Liver Dis. 2014;18:91-112. https://doi.org/10.1016/j.cld.2013.09.009
Softic S, Cohen DE, Kahn CR. Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease. Dig Dis Sci. 2016;61:1282-1293. https://doi.org/10.1007/s10620-016-4054-0
Bray GA. Soft drink consumption and obesity: It is all about fructose. Curr Opin Lipidol. 2010;21:51-57. https://doi.org/10.1097/MOL.0b013e3283346ca2
Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr. 2004;79:537-543. https://doi.org/10.1093/ajcn/nqx044
Lim JS, Mietus-Snyder M, Valente A, et al. The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome. Nat Rev Gastroenterol Hepatol. 2010;7:251-264. https://doi.org/10.1038/nrgastro.2010.41
Mayes PA. Intermediary metabolism of fructose. Am J Clin Nutr. 1993;58: 754s-765s. https://doi.org/10.1093/ajcn/58.5.754S
Herman MA, Samuel VT. The sweet path to metabolic demise: Fructose and lipid synthesis. Trends Endocrinol Metab. 2016;27:719-730. https://doi.org/10.1016/j.tem.2016.06.005
Volynets V, Machann J, Kuper M A, et al. A moderate weight reduction through dietary intervention decreases hepatic fat content in patients with non-alcoholic fatty liver disease (NAFLD): a pilot study. Eur J Nutr. 2013;52:527-535. https://doi.org/10.1007/s00394-012-0355-z
Mager DR, Iniguez IR, Gilmour S, Yap J. The effect of a low fructose and low glycemic index/load (FRAGILE) dietary intervention on indices of liver function, cardiometabolic risk factors, and body composition in children and adolescents with nonalcoholic fatty liver disease (NAFLD). J Parenter Enter Nutr. 2015;39:73-84. https://doi.org/10.1177/0148607113501201
Misciagna G, Del Pilar Diaz M, Caramia DV, et al. Effect of a Low Glycemic Index Mediterranean Diet on Non-Alcoholic Fatty Liver Disease. A Randomized Controlled Clinici Trial. J Nutr Health Aging. 2017;21:404-412. https://doi.org/10.1007/s12603-016-0809-8
Bawden S, Stephenson M, Falcone Y, et al. Increased liver fat and glycogen stores after consumption of high versus low glycaemic index food: a randomized crossover study. Diabetes Obes Metab. 2017;19:70-77. https://doi.org/10.1111/dom.12784
Zelber-Sagi S, Godos J, Salomone F. Lifestyle changes for the treatment of nonalcoholic fatty liver disease: a review of observational studies and intervention trials. Therap Adv Gastroenterol. 2016;9:392-407. https://doi.org/10.1177/1756283X16638830
Bellentani S, Dalle Grave R, Suppini A, et al. Behavior therapy for nonalcoholic fatty liver disease: the need for a multidisciplinary approach. Hepatology. 2008;47:746-754. https://doi.org/10.1002/hep.22009
McCarthy EM, Rinella ME. The role of diet and nutrient composition in nonalcoholic Fatty liver disease. J Acad Nutr Diet. 2012;112:401-409. https://doi.org/10.1016/j.jada.2011.10.007
Mouzaki M, Allard JP. The role of nutrients in the development, progression, and treatment of nonalcoholic fatty liver disease. J Clin Gastroenterol. 2012;46:457-467. https://doi.org/10.1097/MCG.0b013e31824cf51e
McGuire S. U.S. Department of Agriculture and U.S. Department of Health and Human Services, Dietary Guidelines for Americans, 2010. 7th Edition, Washington, DC, U.S. Government Printing Office, January 2011. Adv Nutr. (Bethesda, Md.). 2011;2:293-294. https://doi.org/10.3945/an.111.000430
Katsagoni CN, Egkomiti A, Papageorgiou M, et al. Improvement in liver function after an intervention based on the Mediterranean diet in patients with non alcoholic fatty liver disease (NAFLD) Clin Nutr ESPEN. 2016;13:57. https://doi.org/10.1016/j.clnesp.2016.03.012
Micha R, Mozaffarian D. Trans fatty acids: effects on metabolic syndrome, heart disease and diabetes. Nat Rev Endocrinol. 2009;5:335-344. https://doi.org/10.1038/nrendo.2009.79
Dorfman SE, Laurent D, Gounarides JS, et al. Metabolic Implications of Dietary Trans-fatty Acids. Send to Obesity. 2009;17(6):1200-1207. https://doi.org/10.1038/oby.2008.662
Koppe SWP, Elias M, Moseley RH, Green RM. Trans fat feeding results in higher serum alanine aminotransferase and increased insulin resistance compared with a standard murine high-fat diet. Am J Physiol Gastrointest Liver Physiol. 2009;297:G378-G384. https://doi.org/10.1152/ajpgi.90543.2008
Kirk E, Reeds DN, Finck BN, et al. Dietary Fat and Carbohydrates Differentially Alter Insulin Sensitivity During Caloric Restriction. Gastroenterology. 2009;136:1552-1560. https://doi.org/10.1053/j.gastro.2009.01.048
Havel PJ. Dietary Fructose: Implications for Dysregulation of Energy Homeostasis and Lipid/Carbohydrate Metabolism. Nutrition Reviews. 2005;63:133-157.
Drapkina OM, Shepel RN. Omega-3 fatty acids and age-related diseases: realities and prospects. Rational Pharmacotherapy in Cardiology. 2015;11(3):309-316. (In Russ.) https://doi.org/10.20996/1819-6446-2015-11-3-309-316
Clarke SD. Nonalcoholic steatosis and steatohepatitis. I Molecular mechanism for.polyunsaturated fatty acid regulation of gene transcription. Am J Physiol Gastrointest Liver Physiol. 2001;281:G865-G869. https://doi.org/10.1152/ajpgi.2001.281.4.G865
Spadaro L, Magliocco O, Spampinato D, et al. Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease. Digestive and Liver Disease. 2008;40:194-199. https://doi.org/10.1016/j.dld.2007.10.003
Garg A. High-monounsaturated-fat diets for patients with diabetes mellitus: a meta-analysis. Am J Clin Nutr. 1998;67:577S-582S. https://doi.org/10.1093/ajcn/67.3.577S
Bezerra Duarte SM, Faintuch J, Stefano JT Sobral de Oliveira MB, et al. Hypocaloric high-protein diet improves clinical and biochemical markers in patients with nonalcoholic fatty liver disease (NAFLD). Nutr Hosp. 2014;29:94-101. https://doi.org/10.3305/nh.2014.29.1.7068
Wolfe BM, Piche LA. Replacement of carbohydrate by protein in a conventional-fat diet reduces cholesterol and triglyceride concentrations in healthy normolipidemic subjects. Clin Investig Med Med Clin Exp. 1999;22:140-148.
Campmans-Kuijpers MJ, Sluijs I, Nothlings U, et al. Isocaloric substitution of carbohydrates with protein: The association with weight change and mortality among patients with type 2 diabetes. Cardiovasc Diabetol. 2015;14:39. https://doi.org/10.1186/s12933-015-0202-7
Estes C, Razavi H, Loomba R, et al. Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease. Hepatology. 2018 Jan;67(1):123-133. https://doi.org/10.1002/hep.29466
Schugar RC, Crawford PA. Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease. Current opinion in clinical nutrition and metabolic care. 2012;15(4):374-380. https://doi.org/10.1097/MCO.0b013e3283547157
Thoma C, Day CP, Trenell MI. Lifestyle interventions for the treat-ment of non-alcoholic fatty liver disease in adults: a systematic review. J Hepatol. 2012;56:255-266. https://doi.org/10.1016/j.jhep.2011.06.010
Ryan MC, Itsiopoulos C, Thodis T, et al. The Mediterranean diet improves hepatic steatosis and insulin sen-sitivity in individuals with non-alcoholic fatty liver disease. J Hepatol. 2013;59:138-143. https://doi.org/10.1016/j.jhep.2013.02.012
Gelli C, Tarocchi M, Abenavoli L, et al. Effect of a counseling-supported treatment with the Mediterranean diet and physical activity on the severity of the non-alcoholic fatty liver disease. World J Gastroenterol. 2017;23:3150-3162. https://doi.org/10.3748/wjg.v23.i17.3150
Katsagoni CN, Georgoulis M, Papatheodoridis GV, et al. Effects of lifestyle interventions on clinical characteristics of patients with non-alcoholic fatty liver disease: a metaanalysis. Metabolism. 2017;68:119-132. https://doi.org/10.1016/j.metabol.2016.12.006
Koopman KE, Caan MW, Nederveen AJ, et al. Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: a randomized controlled trial. Hepatology. 2014;60:545-553. https://doi.org/10.1002/hep.27149
Zelber-Sagi S, Salomone F, Webb M, et al. Coffee consumption and nonalcoholic fatty liver onset: A prospective study in the general population. Transl Res. 2015;165:428-436. https://doi.org/10.1016/j.trsl.2014.10.008
Saab S, Mallam D, Cox and GA, Tong MJ. Impact of coffee on liver diseases: a systematic review. Liver Int. 2014;34:495-504. https://doi.org/10.1111/liv.12304
Liangpunsakul S, Chalasani N. What should we recommend to our patients with NAFLD regarding alcohol use? Am J Gastroenterol. 2012;107:976-978. https://doi.org/10.1038/ajg.2012.20
Kwon HK, Greenson JK, Conjeevaram HS. Effect of lifetime alcohol consumption on the histological severity of non-alcoholic fatty liver disease. Liver Int. 2014;34:129-135.
Dunn W, Sanyal AJ, Brunt EM, et al. Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with non-alcoholic fatty liver disease (NAFLD). J Hepatol. 2012;57:384-391.
Ascha MS, Hanouneh IA, Lopez R, et al. The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology. 2010;51:1972-1978.
Sato K, Gosho M, Yamamoto T, et al. Vitamin E has a beneficial effect on nonalcoholic fatty liver disease: a metaanalysis of randomized controlled trials. Nutrition. 2015;31:923-930. https://doi.org/10.1016/j.nut.2014.11.018
Eliades M, Spyrou E. Vitamin D: A new player in non-alcoholic fatty liver disease? World J Gastroenterol. 2015;21:1718-1727. https://doi.org/10.3748/wjg.v21.i6.1718
Mokhtari Z, Poustchi H, Eslamparast T, Hekmatdoost A. Egg consumption and risk of non-alcoholic fatty liver disease. World Journal of Hepatology. 2017;9(10):503-509. https://doi.org/10.4254/wjh.v9.i10.503
Anty R, Marjoux S, E Marinè‐Barjoan E. Regular coffee but not espresso drinking is protective against fibrosis in a cohort mainly composed of morbidly obese European women with NAFLD undergoing bariatric surger. J Hepatol. 2012 Nov;57(5):1090-1096. https://doi.org/10.1016/j.jhep.2012.07.014
Molloy JW, Calcagno CJ, Williams CD, et al. Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis. Hepatology. 2012;55(2):429-436. https://doi.org/10.1002/hep.24731
Georgoulis M, Kontogianni M D, Margariti A, et al. Associations between dietary intake and the presence of the metabolic syndrome in patients with non-alcoholic fatty liver disease. J Hum Nutr Diet. 2015;28(4):409-415. https://doi.org/10.1111/jhn.12323
Aller R, de Luis DA, Izaola O, et al. Effect of a high monounsaturated vs high polyunsaturated fat hypocaloric diets in nonalcoholic fatty liver disease. Eur Rev Med Pharmacol Sci. 2014;18(7):1041-1047.
Shidfar F, Bahrololum SS, Doaei S, et al. The Effects of Extra Virgin Olive Oil on Alanine Aminotransferase, Aspartate Aminotransferase, and Ultrasonographic Indices of Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients Undergoing Low Calorie Diet. Send to Can J Gastroenterol Hepatol. 2018;2018:1053710. https://doi.org/10.1155/2018/1053710
Rocha R, Cotrim HP, Siqueira AC, Floriano S. Nonalcoholic fatty liver disease: treatment with soluble fibres. Arq Gastroenterol. 2007;44:350-352. https://doi.org/10.1590/S0004-28032007000400013

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