By taking into account the professional features of employees, the multifactor prevention of hypertensive disease as an on-site health school reduces morbidity and mortality rates. Objective — to develop an organization model to optimize the outpatient prevention of hypertensive disease in the members of locomotive crews, by estimating sociomedical and economic benefits. Subjects and methods. Two groups of patients matched for gender, age, and disease severity were compared. A study group included 251 patients with Stage I-II hypertensive disease who attended on-site health schools. A control group consisted of 250 hypertensive patients receiving conventional treatment. Results. After 12 months, the proportion of patients measuring their blood pressure (BP) regularly was 2.2-fold higher than that before school attendance. After school attendance, the proportion of the study group patients taking antihypertensive drugs regularly increased up to 83.8%; the proportion of those who had BP goals increased at 3 months of their school attendance and was 63.5% at 12 months. At 12-month follow-up, the indicators characterizing the state of target organs improved. Thus, the number of patients with left ventricular hypertrophy declined from 82.4 to 67.4%. The proportion of patients with diastolic dysfunction also reduced significantly from 79 to 45%. After school attendance, there were reductions in the number of hypertensive patients seeking all kinds of medical care for their worse health and in temporary disability cases. Conclusion. To set up on-site health schools can get the working citizens’ education system going. The education makes the patient take an active stance toward the disease and improves his/her motivation to follow prevention recommendations. The introduction of an on-site health school into the prevention system can have a significant sociomedical benefit just during a year, which determines a favorable disease prognosis.