Liver damage in alcoholism (a review of literature)

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Abuse of psychoactive substances, including alcohol, causes morphofunctional disintegrity of a number of organs and systems. Liver damage holds a prominent place in its prevalence among visceropathies in patients with alcohol abuse and alcoholism. An attempt has been made on the basis of the literature to systematize nonspecific and specific factors that play a role in the pathogenesis of liver damage and in the development of alcoholic liver disease proper.

Keywords:

alcoholic liver disease

acetaldehyde.

comorbidity

Authors:

Nikiforov I.A.

FGBOU DPO "Institut povysheniia kvalifikatsii" Federal'nogo mediko-biologicheskogo agentstva Rossii

Chernobrovkina T.V.

FGBOU DPO "Institut povysheniia kvalifikatsii" Federal'nogo mediko-biologicheskogo agentstva Rossii

Zhovnerchuk E.V.

FGBOU DPO "Institut povysheniia kvalifikatsii" Federal'nogo mediko-biologicheskogo agentstva Rossii

Isaev R.N.

OOO "Ne Zavisimost'"

Kazantsev A.V.

OOO "Ne Zavisimost'"

Zhuĭkov V.Iu.

Poliklinika g. Lytkarino, Moskovskaia obl.

Gantseva I.P.

Tsentral'naia poliklinika OAO RZhD, Moskva

Matushkin A.A.

FGBOU DPO "Institut povysheniia kvalifikatsii" Federal'nogo mediko-biologicheskogo agentstva Rossii

Matushkina T.S.

FGBOU DPO "Institut povysheniia kvalifikatsii" Federal'nogo mediko-biologicheskogo agentstva Rossii

Nikiforov I.I.

FGBOU DPO "Institut povysheniia kvalifikatsii" Federal'nogo mediko-biologicheskogo agentstva Rossii

List of references:

Koshkina E.A., Kirzhanova V.V., Vanisova H.G. et al. Sostoyanie narkolgicheskoy sluzhby I osnovnye tendentsii uchtyonnoy zabolevaemosti v Rossiyskoy Federatsii v 2006 g. Statisticheskaya obrabotka [The state of the narcological service and the main tendencies in the registered morbidity in the Russian Federation in 2006]. M.: NNTs Narkologii 2007. [In Russ.].
Koshkina E.A., Pavlovskaya N.I., Yagudina R.I. et al. Mediko-sotsial'nye I ekonomicheskie posledstviya zloupotrebleniya alkogolem v Rossii [The medico-social and economic consequences of alcohol abuse in Russia]. Narkologiya 2009; 11: 24-31. [In Russ.].
Porfil'eva S.S. Patomorfologicheskie izmeneniya v yaichnikakh pri ostrom I khronicheskom otravlenii alkogolem: Avtoref. diss….kand. med. nauk [Pathomorphological changes in the ovaries in the case of acute and chronic alcohol intoxication. Synposis of thesis for candidate of med. sci. degree]. Vladivostok 2007. [In Russ.].
Chernobrovkina T.V., Artemchuk A.F., Sosin I.K., Nikiforov I.A. Problema komorbidnosti I sovremennye formy alkogol'noy bolezni (kliniko-patogenetichesky aspect) [The problem of co-morbidity and present-day forms of alcoholic disease (the clinico-pathogenetic aspect). Narkologiya 2006; 12: 47-70. [In Russ.].
Bubeev Yu.A., Kozlov V.V., Nikiforov I.A. Integrativnye psikhotekhnologii v profilaktike I korrektsii zavisimogo povedeniya [Intregrative psychotechnologies in the prophylaxis and correction of the addictive behaviour]. M.: 2006. [In Russ.].
Lyusov V.A., Kharchenko V.I., Koryakin M.V. et al. Zabolevaemost' naseleniya Rossii alkogolizmom I smertnost' ot bolezney sistemy krovoobrashcheniya I drugikh prichin smerti [The incidence rate of alcoholism among the population of Russia and mortality from the blood circulation disorders and other causes]. Ros kardiol zhurn 2008; 4: 72: 79-92. [In Russ.].
Onishchenko G.G., Egorov V.F. Alkogol'naya situatsia v Rossii. O kontseptsii gosudarstvennoy alkogol'noy politiki v Rossiyskoy fFederatsii [Situation with abusive drinking in Russia. On the concept of the government alcoholic beverage policy in the Russian Federation]. Narkologiya 2002; 1: 3-8. [In Russ.].
Kirzhanova V.V. Dinamika zabolevaemosti narkologicheskimi rasstroistvami v Rossiyskoy Federatsii v 1991 - 2001 gg. [Dynamics of narcotic-related disorders in the Russian Federation in 1991 - 2001]. Narkologiya 2002; 11: 2-7. [In Russ.].
Kirzhanova V.V. Rasprostranennost' psikhicheskikh I povedencheskikh rasstroistv, svyazannykh s upotrebleniem PAV v Rossiyskoy Federatsii [The prevalence of psychic and behavioural disorders related to SAC consumption in the Russian Federation]. Vopr narkol 2003; 3: 47-58. [In Russ.].
Nemtsov A.V. Alkogol'ny uron regionov Rossii [The losses from alcohol abuse in the regions of Russia]. M 2003. [In Russ.].
Zaridze D., Brennan P., Boreham J. et al. Alcohol and cause-specific mortality in Russia: a retrospective case-control study of 48557 adult deaths. Lancet 2009; 373: 2201-2214.
Aksel'rod A.S., Sivolap Yu.P., Syrkin A.L. et al. Arterial'naya gipertenziya I narusheniya serdechnogo ritma u priverzhennykh k terapii patsientov s alkogol'noy zavisimost'yu: osobennosti techeniya I terapii [Arterial hypertension and disturbances of the cardiac rhythm in the therapy-adhered patents suffering alcohol addiction: peculiarities of the clinical picture and treatment]. Narkologiya 2012; 2: 54-62. [In Russ.].
Tarasova N.S. Immunologicheskie factory v povrezhdenii pochek pri khronicheskom alkogolizme [The role of immunological factors in the kidney damage associated with chronic alcoholism]. Klin med 2001; 79: 5: 45-47. [In Russ.].
Ulyanova L.I., Gamaleya N.B., Alekseev L.P. Vliyanie etanola na funktsional'ny potentsial kletok krovi cheloveka [The influence of ethanol on the functional potential of human blood cells]. Narkologiya 2011; 8: 57-65. [In Russ.].
Hillbom M., Saloheimo P., Juvela S. Alcohol consumption, blood pressure, and the risk of stroke. Curr Hupertens Rep 2011; 13: 208-213.
Imhof A., Koenig W. Alcohol in flammation and coronary heart disease. Addct Biol 2003; 8: 271-277.
Pietraszek A., Gregersen S., Hermansen K. Alcohol and type 2 diabetes: a review. Nutr Metabol Cardiovasc Dis 2010; 20: 366-375.
Anderson L.M. Modulation of nitrosamine metabolism by ethanol: Implications of cancer risk. In: Alcohol and Cancer. Ed. R.R. Watson. Boca Ration FL: CRC Press 1992.
Baum M.K., Rafie C., Lai S. et al. Alcohol use accelerates HIV disease progression. AIDS Res Hum Retrovir 2010; 26: 511-518.
Ben-Eliyahu S., Page G.G., Yirmiya R., Taylor A.N. Acute alcohol intoxication suppresses natural killer cell activity and promotes tumor metastases. Nat Med 1996; 2: 457-460.
Cook R.T. Alcohol abuse, alcoholism, and damage to the immune system: a review. Alcohol Clin Exp Res 1998; 22: 1927-1942.
Fiske C.T., Hamilton C.D., Stout J.E. Alcohol use and clinical anifestations of tuberculosis. J Infect 2008; 57: 385-391.
Gitto S., Micco L., Conti F. et al. Alcohol and viral hepatitis: a mini-review. Dig Liver Dis 2009; 41: 67-70.
Happel K.I., Nelson S. Alcohol, immunosupression, and the lung. Proc Am Thorac Soc 2005; 2: 428-432.
Joshi P.C., Guidot D.M. The alcoholic lung: epidemiology, pathophysihology and potential therapies Am J Phys Lung Cell Mol Phys 2007; 292: 813-823.
Krupitsky E.M., Zvartau E.E., Liosnov D.A. et al. Co-morbidity of infections and addictive disease in St. Petersburg and Leningrad Region, Russia. Eur Addict Res 2006; 12: 12-19.
Mason C.M., Dobard E., Zhang R., Nelson S. Alcohol exacerbates mirine pulmonary tuberculosis. Infect Immunol 2004; 72: 2556-2563.
Schiff E.R., Ozden N. Hepatitis C and alcohol. Alcohol Res Halth 2003; 27: 232-239.
Baikova I.E., Nikitin I.G., Gogova L.M. Alkogol'naya bolezn' pecheni [Alcoholic liver disease]. Rus med zhurn 2011; 17: 1067-1072. [In Russ.].
Nikitin I.G. Alkogol'naya bolezn' pecheni; immunologicheskie mekhanizmy patogeneza [Alcoholic liver disease: immunological mechanisms of pathogenesis]. Narkologiya 2007; 6: 53-56. [In Russ.].
Kalinin A.V. Voprosy patogeneza, klinika I lechenie alkogol'noy bolezni pecheni [The problems of pathogenesis , clinical features, and treatment of alcoholic liver disease]. Klin perspekt gastroenterol gepatol 2001; 4: 8-14. [In Russ.].
Al'tshuler V.B., Tuchkova N.E., Kravchenko S.L. Sravnitel'nye rezul'taty magnitno-rezonansnoy tomografii golovnogo mozga u bol'nykh alkogolizmom zhenshchin I muzhchin [The comparative results of magnetic resonance tomography of the brain of the womwn and men suffering from alcoholism]. Vopr narkol 2004; 2: 24-31. [In Russ.].
Al'tshuler V.B., Kravchenko S.L. Tipologiya alkogolizma u zhenshchin: progredientnost', techenie, prognoz: Posobie dlya vrachey [Typing of alcoholism in the women: progression, clinical picture, prognosis: The manual for physicians]. M 2004.[In Russ.].
Kostyukevich O.I. Alkogol'nye porazheniya pecheni: sotsial'noe zvuchnaie, klinicheskie posledstviya I aspekty patogeneticheskoy terapii [Liver damages caused by alcohol misuse: Social significance, clinical consequences, and aspects of pathogenetic therapy]. Rus med zhurn 2007; 2 : 62-68. [In Russ.].
Kravchenko S.L. Techenie alkogolizma u zhenshchin: rol' terapii [The clinical course of alcoholism in the women: the role of therapy]. Vopr narkol 2006; 4: 11-18. [In Russ.].
Mordasova V.I. Geptor v lechenii alkogol'noy bolezni pecheni [The use of Heptor for the treatment of alcoholic liver disease]. Rus med zhurn 2010; 13: 824-830. [In Russ.].
Panchenko L.F., Ogurtsov P.P., Pirozhkov S.V., Terebilina N.N. et al. Pechyonochnaya nedostatochnost' I mediatory vospalitel'nogo otveta pri alkogol'noy bolezni pecheni I kardiomiopatii [Hepatic insufficiency and mediators of the inflammatory response in alcoholic liver disease and cardiomyopathy]. Narkologiya 2011; 6: 47-55. [In Russ.].
Wagnerberger S., Shafer C., Schwarz E. et. al. Is nutrient intake a gender-specific cause for enhanced susceptibility to alcohol-induced liver disease in women? Alcoholism 2008; 43: 1: 9-14.
Abdurakhmanov D.T. Alkogol'ny gepatit [Alcoholic hepatitis]. Klin gepatol 2008; 4: 2: 3-10. [In Russ.].
Vysokogorsky V.E., Arzamasova O.A., Kurch N.M. Vliyanie prenatal'noy alkogol'noy intoksikatsii na metabolism uglevod-belkovykh kompleksov pecheni I podzheludochnoy zhelezy [The influence of prenatal alcoholic intoxication on the metabolism of carbohydrate-protein complexes in the liver and pancreas]. Narkologiya 2010; 8: 72-75. [In Russ.].
Koryakin A.M., Epifantseva N.N., Dadyka I.V. et al. Oksidativny stress I povrezhdenie sosudistogo endoteliya u bol'nykh alkogolismom II stadii [Oxidative stress and damages to vascular endohthelium in the patients presenting with grade II chronic alcoholism]. Narkologiya 2009; 10: 50-53. [In Russ.].
Egorov A.Yu. Sovremennye osobennosti alkogolizma u zhenshchin: vozrastnoy aspect {Current peculiarities of alcoholism in the women: the age-related aspect]. Narkologiya 2005; 9: 49-55. [In Russ.].
Nikiforov I.A., Chernobrovkina T.V. O ranney diagnostike somaticheskoy patologii, soputstvuyushchey zloupotrebleniyu alkogolem u podrostkov zhenskogo pola. 60 let v nauke I praktike: materialy Yubileinoy nauchno-prakticheskoy konferentsii bol'nitsy No 85 [ On the early diagnostics of somatic pathology accompanying alcohol abuse in the adolescents of the female gender. 60 years in science and practice: materials of the Jubilee scientific and practical conference of Hospital No 85]. M 2008. [In Russ.].
Panchenko L.F., Pirozhkov S.V., Dudko T.N., Baronets V.Yu et al. Gendernye razlichiya v dinamike somaticheskoy patologii u bol'nykh alkogolizmom v abstinentnom periode [The gender-specific differences in the dynamics of somatic pathology between the patients with alcoholism during the period of abstinence]. Vopr narkol 2008; 6: 42-47.[In Russ.].
Meier P., Seitz H. Age, alcohol metabolism and liver disease. Curr Opin Clin Nutr Metabol Care 2008; 11: 1: 21-26.
Feldman M., Friedman L.S., Sleisenger M.H. Gastrointestinal and liver disease. Sanders 2002.
Bueverov A.O., Pavlov A.I., Ivashkin V.T. Alkogol'naya bolezn' pecheni: Vozmozhno li uluchshenie prognoza? [Alcoholic liver disease: Is it possible to improve its prognosis?]. Klin perspekt gastroenterol gepatol 2011; 2: 3-10. [In Russ.].
Vertkin A.L., Zairat'yants O.V., Vovk E.I. Okonchatelny diagnoz [The definitive diagnosis]. M 2008. [In Russ.].
Vertkin A.L. Osobennosti klinicheskogo techeniya I farmakoterapii alkogol'noy bolezni pecheni, serdtsa I golovnogo mozga u bol'nykh somaticheskoy patologiey [Specific features of the clinical course and pharfmacotherapy of alcoholic disease of the liver, heart, and brain in the patients presenting with somatic pathology]. Lechashchiy vrach, 2009; 7: 64-69. [In Russ.].
Chernobrovkina T.V. Laboratornaya diagnostika kak instrument v reshenii zadach profilakticheskoy I klinicheskoy narkologii. Posobie dlya vrachei [Laboratory diagnostics as an instrument for addressing the problems of prophylactic and clinical nacology. The manual for physicians]. M 1999. [In Russ.].
Chernobrovkina T.V. Laboratornaya diagnostika kak instrument v reshenii zadach profilakticheskoy I klinicheskoy narkologii. Posobie dlya vrachei. 2-e izd. [Laboratory diagnostics as an instrument for addressing the problems of prophylactic and clinical nacology. The manual for physicians. 2nd edition]. 2005. [In Russ.].
Avtsyn A.P., Zhavoronkov A.A., Rish M.A et al. Mikroelementy cheloveka: etiologiya, klassifikatsiya, organopatologiya [Microelements in man: etiology, classification, and organ pathology]. M 1991. [In Russ.].
Skal'ny A.V. Mikroelementy cheloveka (diagnostika I lechenie). Prakticheskoe rukovodstvo dlya vrachey I studentov meditsinskikh vuzov [Microelements in man (diagnostics and treatment). The practical guidelines for the physicians and medical students]. M 1999. [In Russ.].
Kono H., Rusyn I., Yin M. NADPH oxidase-derived free radicals ore key oxidants in alcohol-induced liver disease. J Clin Invest 2000; 106: 867.
Wheller M. Ethanol and HCV-induced cytotoxicity: the perfect storm. Gastroenterology 2005; 128: 232-234.
Vovk E.I. Zhirovaya bolezn' pecheni v praktire terapevta [Fatty liver disease in the practical work of a therapist]. Rus med zhurn 2009; 2: 33-48.
Sosin I.K., Artemchuk A.F., Chuev Yu.F. et al. Endoekologiya I ee prikladnye aspekty v narkologii [Endoecology and its applications in narcology]. Mezhdunar med zhurn 2000; 6: 2: 82-85. [In Russ.].
Chernobrovkina T.V. Fermetemii i fiziologo-biokhimicheskaya adapratsiya pri zabolevaniyakh s chemicheskoy zavisimost'yu. Avtoref. diss…d-ra med. nauk [Fermentemias and physiological/biochemical adaptation in chemically dependent diseases. Synopsis of thesis for the degree of doctor med. sci.]. M 1996. [In Russ.].
Registr lekarstvennykh sredstv Rossii. RLS. Entsiklopediya lekarstv, 16-y vyp. Gl. Red. G.L. Vyshkovsky [The registry of medicinal preparations of Russia. RMP. Encyclopedia of medicines. 16th issue. Editor in chief G.L. Vyshkovsky]. M 2007. [In Russ.].
O'Shea R.S., Dasarathy S., Mc Cullough A.J. Alcoholic liver disease. Hepatology 2010; 51: 307-328.
Bisheva I.V., Gamaleya N.B., Dmitrieva I.G., Nadezhdin A.V. et al. Dinamika pokazateley oksidantnogo stressa, sistemy antioksidantnoy zashchity, endogennoy intoksikatsii I biokhimicheskikh markerov porazhenia pecheni u bol'nykh alkogolizmom pri lechenii immunomodulyatorom polioxidoniem [Dynamics of oxidative stress, parameters of the system of antioxidative protection, endogenous intoxication, and biochemical markers of liver damages in the patients suffering from alcoholism during the treatment with the immunomodulator polyoxidonium]. Narkologiya 2007; 7: 40-45. [In Russ.].
Shul'pekova Yu.O. Alkogol'naya bolezn' pecheni: opirayas' na zamechatel'nye raboty Ch.S. Libera [Alcoholic liver disease: relying on the remarkable works of C.S. Lieber]. Rus med zhurn 2010; 13: 815-819. [In Russ.].
Lieber C.S. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcoholism 2004; 34: 9-19.
Sorrel M.F., Tuma D.I. Hupotesis: alcoholic liver injury and the covalent binding of acetaldehyde. Alcohol clin 1998; 9: 306-310.
Kurysheva M.A. Fibroz pecheni: proshloe, nastoyashchee I budushchee [Liver fibrosis: the past, present, and future]. Rus med zhurn 2010; 28: 1713-1717. [In Russ.].
Rukiovodstvo po narkologii v 2-kh tomakh. Pod red. N.N. Ivantsa [The guidelines on narcology in 2 volumes. Red. N.N. Ivanets]M 2002. [In Russ.].
Adzhigaitkanova S.K. Alkogol'ny gepatit: osnovnye printsipy lechenia [Alcoholic hepatitis: the main principles of its treatment]. Rus med zhurn 2008; 1: 15-20. [In Russ.].
Jeong W., Gao B. Innate immunity and alcoholic liver fibrosis. J Gastroenterol Hepatol 2008; 23: Suppl: 1: 118.
Rolla R., Vay D., Mottaran E. Detection of circulation antibodies against malondialdehyde-acetaldehyde adducts in patients with alcohol-induced liver disease. Hepatology 2000; 31: 878.
Bogomolov D.V., Pavlov A.L., Panchenko L.F., Bukeshev M K Patologiya I klinicheskie osobennosti otravleniya surrogatnym alkogolem [Pathology and clinical peculiarities of intoxication with surrogate alcohol ]. Narkologiya 2006; 3: 42-46. [In Russ.].
Erokhin Yu.A. Patologicheskaya anatomiya alkogol'noy bolezni. Avtoref. diss…d-ra med. nauk [Pathological anatomy of alcoholic disease. Synopsis of thesis for the degree of doctor med. sci.]. M 2009. [In Russ.].
Moskvichev V.G., Vertkin A.L., Volokhova R.Yu., Zinov'eva M.A. Alkogol'-assotsiirovannye zabolevaniya pecheni: klinika, lechenie I prognoz dlya zhizni [Alcohol-associated liver diseases: the clinical picture, treatment, and life expectancy prognosis]. Zhurn Doktor.ru 2005; 5. [In Russ.].
Ogurtsov P.P., Mazurchik N.V., Martynov A.Yu. Somaticheskie narusheniya pri alkogolizme [Somatic disordedrs associated with alcoholism]. Psikhicheskie rasstroistva obshchey meditsiny 2005. [In Russ.].
Poinard T., Man-Fung E., Ratziu V., Ching Lung Lai. Virusny gepatit C. Virusnye gepatity u potrebiteley in'ektsionnykh narkotikov: profilaktika, klinika, lechenie, koinfektsiya VICh [Viral hepatitis. Viral hepatitis in the users of injectable drugs: prophylaxis, clinical picture, treatment, HIV co-infection]. Sbornik statey. Minsk 2006. [In Russ.].

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