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Adamyan L.V.

Russian Medical University;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Osipova A.A.

Russian Medical University

Pivazyan L.G.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Kurbatova K.S.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine

Mailova K.S.

FSBEI HE «RosUniMed» of MOH of Russia

Avetisyan D.S.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Stepanian A.A.

Academia of Women’s Health and Endoscopic Surgery

Oxidative stress and antioxidant therapy in the treatment of premature ovarian insufficiency and improving the quality of life

Authors:

Adamyan L.V., Osipova A.A., Pivazyan L.G., Kurbatova K.S., Mailova K.S., Avetisyan D.S., Stepanian A.A.

More about the authors

Journal: Russian Journal of Human Reproduction. 2025;31(1): 21‑34

DOI: 10.17116/repro20253101121

Views: 372

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Table of contents

OXIDATIVE STRESS AND ANTIOXIDANT THERAPY IN THE TREATMENT OF PREMATURE OVARIAN INSUFFICIENCY AND IMPROVING THE QUALITY OF LIFE
OXIDATIVE STRESS AND ANTIOXIDANT THERAPY IN THE TREATMENT OF PREMATURE OVARIAN INSUFFICIENCY AND IMPROVING THE QUALITY OF LIFE

To cite this article:

Adamyan LV, Osipova AA, Pivazyan LG, Kurbatova KS, Mailova KS, Avetisyan DS, Stepanian AA. Oxidative stress and antioxidant therapy in the treatment of premature ovarian insufficiency and improving the quality of life. Russian Journal of Human Reproduction. 2025;31(1):21‑34. (In Russ.)
https://doi.org/10.17116/repro20253101121

 
 
Подписка 2025-2 (Russian Journal of Human Reproduction)
 
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Reactive oxygen species (ROS), at physiological concentrations, play a key role in regulating follicular growth, angiogenesis, and the biosynthesis of sex steroids in ovarian tissue. An imbalance between ROS and the body’s antioxidant system leads to oxidative stress (OS), which results in the degradation of both the quantitative and qualitative characteristics of oocytes. This review analyzes the relationship between OS and premature ovarian insufficiency (POI), highlights potential pathogenic mechanisms, and explores treatment approaches for POI through the modulation of OS levels via antioxidant therapy. It has been established that OS plays a significant role in genetic material damage, disrupts signaling pathways, transcription factor expression, and alters the oocyte microenvironment, ultimately leading to apoptosis of granulosa cells (GCs), disruption of meiotic division, reduction in mitochondrial DNA (mtDNA) content, and other pathophysiological changes that accelerate ovarian aging. Antioxidants, mesenchymal stem cells (MSCs), biological enzymes, and other antioxidant agents have the potential to slow down the progression of POI by reducing ROS concentrations, representing a promising direction for improving the quality of life and reproductive outcomes in patients with POI.

Keywords:

premature ovarian insufficiency
POI
reproduction
antioxidant therapy
iron
folliculogenesis

Authors:

Adamyan L.V.

Russian Medical University;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Osipova A.A.

Russian Medical University

Pivazyan L.G.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Kurbatova K.S.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine

Mailova K.S.

FSBEI HE «RosUniMed» of MOH of Russia

Avetisyan D.S.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Stepanian A.A.

Academia of Women’s Health and Endoscopic Surgery

Received:

08.10.2024

Accepted:

20.12.2024

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