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Adamyan L.V.
Russian Medical University;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Osipova A.A.
Russian Medical University
Pivazyan L.G.
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Kurbatova K.S.
Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine
Avetisyan D.S.
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Stepanian A.A.
Academia of Women’s Health and Endoscopic Surgery
Oxidative stress and antioxidant therapy in the treatment of premature ovarian insufficiency and improving the quality of life
Journal: Russian Journal of Human Reproduction. 2025;31(1): 21‑34
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To cite this article:
Adamyan LV, Osipova AA, Pivazyan LG, Kurbatova KS, Mailova KS, Avetisyan DS, Stepanian AA. Oxidative stress and antioxidant therapy in the treatment of premature ovarian insufficiency and improving the quality of life. Russian Journal of Human Reproduction.
2025;31(1):21‑34. (In Russ.)
https://doi.org/10.17116/repro20253101121
Reactive oxygen species (ROS), at physiological concentrations, play a key role in regulating follicular growth, angiogenesis, and the biosynthesis of sex steroids in ovarian tissue. An imbalance between ROS and the body’s antioxidant system leads to oxidative stress (OS), which results in the degradation of both the quantitative and qualitative characteristics of oocytes. This review analyzes the relationship between OS and premature ovarian insufficiency (POI), highlights potential pathogenic mechanisms, and explores treatment approaches for POI through the modulation of OS levels via antioxidant therapy. It has been established that OS plays a significant role in genetic material damage, disrupts signaling pathways, transcription factor expression, and alters the oocyte microenvironment, ultimately leading to apoptosis of granulosa cells (GCs), disruption of meiotic division, reduction in mitochondrial DNA (mtDNA) content, and other pathophysiological changes that accelerate ovarian aging. Antioxidants, mesenchymal stem cells (MSCs), biological enzymes, and other antioxidant agents have the potential to slow down the progression of POI by reducing ROS concentrations, representing a promising direction for improving the quality of life and reproductive outcomes in patients with POI.
Keywords:
Authors:
Adamyan L.V.
Russian Medical University;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Osipova A.A.
Russian Medical University
Pivazyan L.G.
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Kurbatova K.S.
Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine
Avetisyan D.S.
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Stepanian A.A.
Academia of Women’s Health and Endoscopic Surgery
Received:
08.10.2024
Accepted:
20.12.2024
List of references:
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