Autoimmunity and premature ovarian insufficiency — up-to-date

Adamyan L.V.; Pivazyan L.G.; Antonova A.A.

doi:https://doi.org/10.17116/repro202228061116

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INTRODUCTION

Premature ovarian insufficiency (POI), formerly known as premature menopause, is defined by the loss of ovarian function before the age of 40 years. Autoimmunity is responsible for 4—30% of POI cases. The purpose of this literature review is to search for and evaluate publications on the topic of autoimmune POI in order to study current data on the etiological causes and possible correction of this condition.

MATERIAL AND METHODS

We conducted an electronic search in the PubMed databases and the Cochrane Library up to November 2022 using the keywords (premature ovarian insufficiency) AND (autoimmune); ((signaling) AND (autoimmune)) AND (premature ovarian insufficiency). We considered publications in English over the past 3 years that studied the relationship of autoimmunity with POI in clinical and experimental studies.

RESULTS AND CONCLUSIONS

The diagnosis of autoimmune etiology of POF remains complex and depends on several clinical, immunological, and histological features that should be investigated in this patient cohort. Patients with POI need a comprehensive approach, including the search for an autoimmune etiology of this condition. Unfortunately, there are no clinical guidelines for the treatment of autoimmune POI. Moreover, although strategies have been proposed for the treatment of infertility in POI using corticosteroids to restore ovarian function, its use is still controversial.

Keywords:

premature ovarian insufficiency

POI

autoimmune disorders

Authors:

Adamyan L.V.

Moscow State Medical and Dental University named after A.I. Evdokimov

SPIN RSCI: 9836-2713
Scopus AuthorID: 7006372422
ResearcherID: Q-1722-2018
ORCID: 0000-0002-3253-4512

Pivazyan L.G.

National medical research center for obstetrics, gynecology and perinatology named after academician V.I. Kulakov

ORCID: 0000-0002-6844-3321

Antonova A.A.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov

ORCID: 0000-0002-6011-3889

Received:

05.11.2022

Accepted:

24.11.2022

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