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Adamyan L.V.

Moscow State Medical and Dental University named after A.I. Evdokimov

Vechorko V.I.

Filatov City Clinical Hospital No.15 of the Moscow Departament of Health

Elagin V.V.

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

Dashko A.A.

O.M. Filatov City clinical hospital No 15

Doroshenko D.A.

O.M. Filatov City clinical hospital No 15

Stepanian A.A.

Academia of Women’s Health and Endoscopic Surgery

Medvedeva I.V.

O.M. Filatov City clinical hospital No.15

Sorokin M.I.

Moscow Institute of Physics and Technology;
World-Class Research Center "Digital biodesign and personalized healthcare" of the I.M. Sechenov First Moscow State Medical University (Sechenov University)

Suntsova M.V.

World-Class Research Center "Digital biodesign and personalized healthcare" of the I.M. Sechenov First Moscow State Medical University (Sechenov University)

Efimov V.O.

Moscow Institute of Physics and Technology

Buzdin A.A.

Moscow Institute of Physics and Technology;
World-Class Research Center "Digital biodesign and personalized healthcare" of the I.M. Sechenov First Moscow State Medical University (Sechenov University)

COVID-19 vaccine does not affect male reproductive health (based on RNA-sequencing data)

Authors:

Adamyan L.V., Vechorko V.I., Elagin V.V., Dashko A.A., Doroshenko D.A., Stepanian A.A., Medvedeva I.V., Sorokin M.I., Suntsova M.V., Efimov V.O., Buzdin A.A.

More about the authors

Journal: Russian Journal of Human Reproduction. 2021;27(5): 8‑12

DOI: 10.17116/repro2021270518

Views: 3166

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Table of contents

COVID-19 VACCINE DOES NOT AFFECT MALE REPRODUCTIVE HEALTH (BASED ON RNA-SEQUENCING DATA)
COVID-19 VACCINE DOES NOT AFFECT MALE REPRODUCTIVE HEALTH (BASED ON RNA-SEQUENCING DATA)

To cite this article:

Adamyan LV, Vechorko VI, Elagin VV, et al. . COVID-19 vaccine does not affect male reproductive health (based on RNA-sequencing data). Russian Journal of Human Reproduction. 2021;27(5):8‑12. (In Russ.)
https://doi.org/10.17116/repro2021270518

Подписка 2025-2 (Russian Journal of Human Reproduction)
 
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OBJECTIVE

To evaluate the effect of COVID-19 vaccine on molecular features of semen samples based on the gene expression analysis.

MATERIAL AND METHODS

10 men of reproductive age with no history of laboratory-confirmed COVID-19 were inlcuded in this study. Six men were planning to get vector-based COVID-19 vaccine Gam-COVID-Vac (Sputnik V) of the Gamaleya National Research Center for Epidemiology and Microbiology, four men were included in the control group. Gene expression level in semen samples of men who received COVID-19 vaccine was analyzed using RNA-sequencing (semen samples were collected prior to the vaccination and 75 days after the administration of the second dose of the Gam-COVID-Vac vaccine). The semen samples, collected of men of the control group at the same time interval, were also analyzed using RNA-sequencing.

RESULTS

Comparative analysis of the gene expression level in the semen samples collected prior to and after getting COVID-19 vaccine did not reveal statistically significant changes in the intracellular molecular pathways functioning.

CONCLUSION

Study results indicate the absence of an adverse effects of the Gam-COVID-Vac (Sputnik V) vaccine on molecular features of semen samples.

Keywords:

COVID-19
vaccination
Gam-COVID-Vac
Sputnik V
gene expression
RNA-sequencing

Authors:

Adamyan L.V.

Moscow State Medical and Dental University named after A.I. Evdokimov

Vechorko V.I.

Filatov City Clinical Hospital No.15 of the Moscow Departament of Health

Elagin V.V.

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

Dashko A.A.

O.M. Filatov City clinical hospital No 15

Doroshenko D.A.

O.M. Filatov City clinical hospital No 15

Stepanian A.A.

Academia of Women’s Health and Endoscopic Surgery

Medvedeva I.V.

O.M. Filatov City clinical hospital No.15

Sorokin M.I.

Moscow Institute of Physics and Technology;
World-Class Research Center "Digital biodesign and personalized healthcare" of the I.M. Sechenov First Moscow State Medical University (Sechenov University)

Suntsova M.V.

World-Class Research Center "Digital biodesign and personalized healthcare" of the I.M. Sechenov First Moscow State Medical University (Sechenov University)

Efimov V.O.

Moscow Institute of Physics and Technology

Buzdin A.A.

Moscow Institute of Physics and Technology;
World-Class Research Center "Digital biodesign and personalized healthcare" of the I.M. Sechenov First Moscow State Medical University (Sechenov University)

Received:

10.08.2021

Accepted:

11.08.2021

List of references:

  1. Joint Statement Regarding COVID-19 Vaccine in Men Desiring Fertility from the Society for Male Reproduction and Urology (SMRU) and the Society for the Study of Male Reproduction (SSMR). January 09, 2021. https://ssmr.org/news/statement-from-ssmr-about-covid-19-vaccine.aspx
  2. Safrai M, Reubinoff B, Ben-Meir A. BNT162b2 mRNA Covid-19 vaccine does not impair sperm parameters. medRxiv. May 03, 2021. https://doi.org/10.1101/2021.04.30.21255690
  3. Gonzalez DC, Nassau DE, Khodamoradi K, Ibrahim E, Blachman-Braun R, Ory J, Ramasamy R. Sperm Parameters Before and After COVID-19 mRNA Vaccination. JAMA. 2021 July 20;326(3): 273-274.  https://doi.org/10.1001/jama.2021.9976.
  4. Elagin VV, Adamyan LV, Vechorko VI, Doroshenko DA, Dashko AA, Filippov OS, Stepanian AA, Medvedeva IV. COVID-19 vaccine and male reproductive health (preliminary data). Problemy Reproduktsii. 2021;27(4):17-21. (In Russ.). https://doi.org/10.17116/repro2021270410
  5. Guernsey DL, Jiang H, Hussin J, Arnold M, Bouyakdan K, Perry S, Babineau-Sturk T, Beis J, Dumas N, Evans SC, Ferguson M, Matsuoka M, Macgillivray C, Nightingale M, Patry L, Rideout AL, Thomas A, Orr A, Hoffmann I, Michaud JL, Awadalla P, Meek DC, Ludman M, Samuels ME. Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4. Am J Hum Genet. 2010 July 09;87(1):40-51.  https://doi.org/10.1016/j.ajhg.2010.06.003
  6. Sugimoto K, Koh E, Sin HS, Maeda Y, Narimoto K, Izumi K, Kobori Y, Kitamura E, Nagase H, Yoshida A, Namiki M. Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis. J Hum Genet. 2009 Aug;54(8):450-456.  https://doi.org/10.1038/jhg.2009.59
  7. Liu J, Shen C, Fan W, Chen Y, Zhang A, Feng Y, Li Z, Kuang Y, Wang Z. Low levels of PRSS37 protein in sperm are associated with many cases of unexplained male infertility. Acta Biochim Biophys Sin (Shanghai). 2016 Nov;48(11):1058-1065. https://doi.org/10.1093/abbs/gmw096
  8. Adamyan L, Elagin V, Vechorko V, Stepanian A, Dashko A, Doroshenko D, Aznaurova Y, Sorokin M, Suntsova M, Garazha A, Buzdin A. COVID-19 - associated inhibition of energy accumulation pathways in human semen samples. F&S Science. Aug 05, 2021. Online ahead of print. PMID: 34377996. PMCID: PMC8339600. https://doi.org/10.1016/j.xfss.2021.07.004

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