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Syrkasheva A.G.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Kindysheva S.V.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Frankevich V.E.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Dolgushina N.V.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Paternal blood bisphenol A concentration: impact on IVF outcomes

Authors:

Syrkasheva A.G., Kindysheva S.V., Frankevich V.E., Dolgushina N.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2021;27(4): 135‑141

DOI: 10.17116/repro202127041135

Read: 2309 times

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Table of contents

PATERNAL BLOOD BISPHENOL A CONCENTRATION: IMPACT ON IVF OUTCOMES
PATERNAL BLOOD BISPHENOL A CONCENTRATION: IMPACT ON IVF OUTCOMES

To cite this article:

Syrkasheva AG, Kindysheva SV, Frankevich VE, Dolgushina NV. Paternal blood bisphenol A concentration: impact on IVF outcomes. Russian Journal of Human Reproduction. 2021;27(4):135‑141. (In Russ.)
https://doi.org/10.17116/repro202127041135

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To analyze the relationship between blood bisphenol A levels in men, sperm quality and in vitro fertilization (IVF) outcomes.

MATERIAL AND METHODS

Infertility treatment of 154 married couples was performed using ART. The level of bisphenol A in the blood of patients was determined by gas chromatography-mass spectrometry. The effect of bisphenol A levels on motility, morphology, sperm concentration, and outcomes of IVF cycles was assessed.

RESULTS

Bisphenol A was detected in 91.6% (141/154) of male blood samples in ART programs. No correlation was found between bisphenol A levels, concentration, motility, and sperm morphology. The median sperm concentration in the Q4 subgroup was 1.4 times lower than in the Q1 subgroup. The clinical pregnancy rate did not differ in the Q1-Q4 groups, however, there was a trend towards an increase in the frequency of early reproductive losses with an increase in the level of bisphenol A in the blood. The miscarriage rate was 23.5% in the Q4 group versus 5.6% in the Q1 group and versus 20.8% in the general group of patients.

CONCLUSIONS

Bisphenol A was found in a detectable concentration in the majority of infertile patients. Bisphenol A levels negatively affect sperm concentration and the frequency of early reproductive loss after IVF, which requires further research.

Keywords:

in vitro fertilization
pollutants
pregnancy
mass-spectrometry
bisphenol A
miscarriage
sperm
sperm concentration

Authors:

Syrkasheva A.G.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Kindysheva S.V.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Frankevich V.E.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Dolgushina N.V.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Received:

15.09.2020

Accepted:

25.12.2020

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References:

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