Новая парадигма лютеиновой поддержки в протоколах вспомогательных репродуктивных технологий: системный прогестерон как ключ к успешной имплантации и живорождению

Авторы:

Константин Юрьевич Боярский,

Ирина Вадимовна Зорина,

Ирина Евгеньевна Корнеева,

Алеся Геннадьевна Львова,

Анна Анатольевна Смирнова,

Ринат Рафаилевич Темирбулатов

Журнал: Проблемы репродукции. 2026;32(4):39-50.

DOI: 10.17116/repro20263204139

Прочитано: 77 раз

Резюме

Прогестерон является ключевым системным гормоном в программах вспомогательных репродуктивных технологий, а наибольшее значение контроль его уровня имеет в циклах криопереноса на фоне циклической гормональной терапии, когда дефицит может негативно влиять на исходы беременности. В таких циклах мониторинг уровня прогестерона в сыворотке крови позволяет персонализировать поддержку, а применение водорастворимого прогестерона для подкожного введения обеспечивает надежную системную коррекцию при его субоптимальных значениях или непереносимости вагинальных форм. При сохраненном овуляторном цикле предпочтение может быть отдано естественным и модифицированным естественным протоколам, тогда как выбор упреждающей системной поддержки, сроков снижения дозы прогестерона при беременности и тактики у пациенток группы риска следует осуществлять на основе индивидуального подхода. Эти аспекты должны стать предметом дальнейшего изучения. Цель данного обзора: определить оптимальные подходы к лютеиновой поддержке и персонализации применения прогестерона в программах криопереноса эмбрионов в зависимости от клинической ситуации и уровня прогестерона в сыворотке крови.

Ключевые слова

прогестерон
поддержка лютеиновой фазы
вспомогательные репродуктивные технологии
гормонозаместительные и естественные циклы

Дата поступления: 10.07.2026

Дата принятия в печать: 24.08.2026

Дата публикации: 16.09.2026

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