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Elagin V.V.

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

Adamyan L.V.

Moscow State Medical and Dental University named after A.I. Evdokimov

Vechorko V.I.

Filatov City Clinical Hospital No.15 of the Moscow Departament of Health

Doroshenko D.A.

O.M. Filatov City clinical hospital No 15

Dashko A.A.

O.M. Filatov City clinical hospital No 15

Filippov O.S.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Stepanian A.A.

Academia of Women’s Health and Endoscopic Surgery

Medvedeva I.V.

O.M. Filatov City clinical hospital No.15

COVID-19 vaccine and male reproductive health (preliminary data)

Authors:

Elagin V.V., Adamyan L.V., Vechorko V.I., Doroshenko D.A., Dashko A.A., Filippov O.S., Stepanian A.A., Medvedeva I.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2021;27(4): 17‑21

DOI: 10.17116/repro20212704117

Read: 7497 times

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Table of contents

COVID-19 VACCINE AND MALE REPRODUCTIVE HEALTH (PRELIMINARY DATA)
COVID-19 VACCINE AND MALE REPRODUCTIVE HEALTH (PRELIMINARY DATA)

To cite this article:

Elagin VV, Adamyan LV, Vechorko VI, et al. . COVID-19 vaccine and male reproductive health (preliminary data). Russian Journal of Human Reproduction. 2021;27(4):17‑21. (In Russ.)
https://doi.org/10.17116/repro20212704117

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the effect of COVID-19 vaccine on male reproductive health based on semen analysis, serum level of sex hormones and tropic hormones of anterior pituitary, paraclinical data, etc.

MATERIAL AND METHODS

44 men of reproductive age with no history of laboratory-confirmed COVID-19 who were planning to get vector-based COVID-19 vaccine «Gam-COVID-Vac» («Sputnik-V») of the National Research Center for Epidemiology and Microbiology named after N.F. Gamaleya. All patients included in the study underwent a comprehensive examination at the City Clinical Hospital №15 named after O.M. Filatov, including semen analysis (sperm concentration, motility, morphology; MAR-test), complete blood count, biochemical blood analysis, serum level of hormones (total testosterone, estradiol, FSH, LH, prolactin). Assessment of reproductive health and exclusion of concomitant urological conditions were performed by a urologist-andrologist in all cases.

RESULTS

Comparative study of semen analysis prior to and after getting COVID-19 vaccine revealed some changes that fit into the reference range and were characterized as normozoospermia. It’s important to note that all parameters of hormonal profile and mentioned blood tests were within the reference range.

CONCLUSION

Study results indicate the absence of an adverse effects of the «Gam-COVID-Vac» («Sputnik-V») vaccine on semen parameters and serum level of sex hormones in men of reproductive age.

Keywords:

COVID-19
vaccination
semen analysis
sex hormones

Authors:

Elagin V.V.

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

Adamyan L.V.

Moscow State Medical and Dental University named after A.I. Evdokimov

Vechorko V.I.

Filatov City Clinical Hospital No.15 of the Moscow Departament of Health

Doroshenko D.A.

O.M. Filatov City clinical hospital No 15

Dashko A.A.

O.M. Filatov City clinical hospital No 15

Filippov O.S.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Stepanian A.A.

Academia of Women’s Health and Endoscopic Surgery

Medvedeva I.V.

O.M. Filatov City clinical hospital No.15

Received:

18.06.2021

Accepted:

19.06.2021

Close metadata

References:

  1. Patel DP, Punjani N, Guo J, Alukal JP, Li PS, Hotaling JM. The impact of SARS-CoV-2 and COVID-19 on Male Reproduction and Men’s Health. Fertility and Sterility. 2021;115(4):813-823.  https://doi.org/10.1016/j.fertnstert.2020.12.033
  2. Khalili MA, Leisegang K, Majzoub A, Finelli R, Panner Selvam MK, Henkel R, Mojgan M, Agarwal A. Male Fertility and the COVID-19 Pandemic: Systematic Review of the Literature. The World Journal of Men’s Health. 2020;38(4):506-520.  https://doi.org/10.5534/wjmh.200134
  3. Gacci M, Coppi M, Baldi E, Sebastianelli A, Zaccaro C, Morselli S, Pecoraro A, Manera A, Nicoletti R, Liaci A, Bisegna C, Gemma L, Giancane S, Pollini S, Antonelli A, Lagi F, Marchiani S, Dabizzi S, Degl’Innocenti S, Annunziato F, Maggi M, Vignozzi L, Bartoloni A, Rossolini GM, Serni S. Semen impairment and occurrence of SARS-CoV-2 virus in semen after recovery from COVID-19. Human Reproduction. 2021;36(6):1520-1529. https://doi.org/10.1093/humrep/deab026
  4. Dashko AA, Elagin VV, Kiseleva YuYu, Doroshenko DA, Adamyan LV, Vechorko VI. The impact of a new coronavirus infection on male fertility (preliminary data). Problemy reprodukcii. 2020;26(6): 83-88. (In Russ.). https://doi.org/10.17116/repro20202606183
  5. Schroeder M, Tuku B, Jarczak D, Nierhaus A, Bai T, Jacobsen H, Zickler M, Müller Z, Stanelle-Bertram S, Meinhardt A, Aberle J, Kluge S, Gabriel G. The majority of male patients with COVID-19 present low testosterone levels on admission to intensive care in Hamburg, Germany: a retrospective cohort study. medRxiv. 2020. https://doi.org/10.1101/2020.05.07.20073817
  6. Joint Statement Regarding COVID-19 Vaccine in Men Desiring Fertility from the Society for Male Reproduction and Urology (SMRU) and the Society for the Study of Male Reproduction (SSMR). January 9, 2021. Accessed May 25, 2021. https://ssmr.org/news/statement-from-ssmr-about-covid-19-vaccine.aspx
  7. Sergerie M, Mieusset R, Croute F, Daudin M, Bujan L. High risk of temporary alteration of semen parameters after recent acute febrile illness. Fertility and Sterility. 2007;88(4):970.e1-970.e9707. https://doi.org/10.1016/j.fertnstert.2006.12.045
  8. Safrai M, Reubinoff B, Ben-Meir A. BNT162b2 mRNA Covid-19 vaccine does not impair sperm parameters. medRxiv Preprint. May 3, 2021. https://doi.org/10.1101/2021.04.30.21255690
  9. Centers for Disease Control and Prevention. Possible Side effects from Vaccines. April 2, 2020. Accessed May 25, 2021. https://www.cdc.gov/vaccines/vac-gen/side-effects.htm
  10. Garolla A, Pizzol D, Foresta C. The role of human papillomavirus on sperm function. Current Opinion in Obstetrics and Gynecology. 2011;23(4):232-237.  https://doi.org/10.1097/GCO.0b013e328348a3a4
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