Introduction. Unfavorable socio-economic situation in Russia creates a real threat for the broad spread of environment-dependent diseases, especially in large and urbanized regions. There is an increasing need in accurate and timely information on indicators of health and environment for making urgent priority management solutions, for developing the systems of preventive and diagnostic activities. Objective — to study the impact of environment-polluting factors (water, air, soil) on the levels of some indicators characterizing the reproductive health of the population of the Chuvash Republic in the period of 2013—1016. Material and methods. Assessing the content of chemical substances polluting the environment was conducted in accordance with the Guidelines for Assessing the Risks to Health under the Influence of Chemicals Polluting the Environment 2.1.10.1920-04. Hygienic assessment of aerial environment was conducted basing on the data of laboratory studies performed by the Federal Budget Institution of Public Health «Center of hygiene and epidemiology in the Chuvash Republic — Chuvashia» in 5 posts of social and hygienic monitoring of the ChR in 2013—2016. We calculated the indicators of morbidity and mortality among the working age population, the coefficient of fetoinfantile losses (FIL) as well as we calculated the correlation coefficient between the content of individual chemicals in the environment and indicators of morbidity, mortality for the working age population and FIL. Risk assessment was carried out in four stages: identification of priority pollutants; identification of pollutants; evaluation of the «dose-response» system; risk profile. Results. Stabilization of hazardous substances concentrations in the air in the dynamics in the period under study is noted in the Chuvash Republic. In all regions and towns under study high concentrations of carbon monoxide dominate. The concentration of arsenic, ammonia, nitrate (by nitrogen), mercury, aluminum, lead, barium, zinc in water (up to 1.0 MAC) tends to increase. Nitrates, total hardness, ammonium salt, biochemical oxygen demand — 5 day test (BOd5), sulphates, chlorides and chemical oxygen demand (COD) increased while dissolved oxygen (DO) — decreased. Conclusions. Correlation between morbidity levels of the working-age population and pronouncement of exposure to ammonium chemicals, pH, fluoride is established as well as correlation between mortality levels of the working-age population and pronouncement of exposure to chemical substances of iron, fluoride, chloride and pH level. The value of FIL is affected by COD, ammonium salt, DO, iron, fluoride, total water hardness. Risk assessment results indicate that when chemical substances enter by inhalation, by oral and cutaneous routes, an acceptable level of carcinogenic risk is provided, and the values of chronic non-cancerous risk correspond to the permissible level.