The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Popova O.S.

Federal State Budgetary Educational Institution of Higher Education 'Stavropol State Medical University' of the Ministry of Healthcare of the Russia, Stavropol, Russia

Immune system cells as biomarkers in the diagnostics of endometriosis

Authors:

Popova O.S.

More about the authors

Journal: Russian Journal of Human Reproduction. 2019;25(2): 8‑15

Read: 4576 times


To cite this article:

Popova OS. Immune system cells as biomarkers in the diagnostics of endometriosis. Russian Journal of Human Reproduction. 2019;25(2):8‑15. (In Russ.)
https://doi.org/10.17116/repro2019250218

Recommended articles:
Inflammatory aging. Part 2. Are there diagnostic biomarkers available. Russian Journal of Preventive Medi­cine. 2025;(1):89-95
Obstructive sleep apnea syndrome as a predictor of atrial fibrillation. Russian Journal of Preventive Medi­cine. 2025;(1):109-114
Virus-associated progesterone-resistant chro­nic endo­metritis — the onco­risk situation?. Russian Bulletin of Obstetrician-Gynecologist. 2025;(1):25-30
Modern approaches to cystic lung diseases diagnosis. Journal of Respiratory Medi­cine. 2025;(1):30-37
Primary bile acid synthesis diso­rders. Russian Journal of Evidence-Based Gastroenterology. 2025;(1):71-90

References:

  1. Adamyan LV, Kulakov VI, Andreeva EN. Endometriozy. M.: Meditsina; 2006. (In Russ.)
  2. Fauconnier A, Borghese B, Huchon C, Thomassin-Naggara I, Philip CA, Gauthier T, Bourdel N, Denouel A, Torre A, Collinet P, Canis M, Fritel X. Epidemiology and diagnosis strategy: CNGOF-HAS. Gynécologie, obstétrique, fertilité & sénologie. 2018;46(3):223-230. https://doi.org/10.1016/j.gofs.2018.02.012
  3. Eisenberg VH, Weil C, Chodick G, Shalev V. Epidemiology of endometriosis: a large population-based database study from a healthcare provider with 2 million members. BJOG: An International Journal of Obstetrics and Gynecology. 2018;125(1):55-62. https://doi.org/10.1111/1471-0528.14711
  4. Tikhonchuk EYu, Asaturova AV, Adamyan LV. The detection rate and the structure of pathological changes of the endometrium in women of reproductive age with endometriosis. Materialy kongressa «XI Mezhdunarodnyj kongress po reproduktivnoj medicine». M. 2017;45-47. (In Russ.) Accessed December 17, 2018. Available at:] https://reproductive-congress.ru/library.php
  5. Mechsner S. Endometriosis: An often unrecognized pain disorder. Schmerz. 2016;30(5):477-490. https://doi.org/10.1007/s00482-016-0154-1
  6. Facchin F, Barbara G, Saita E, Mosconi P, Roberto A, Fedele L, Vercellini P. Impact of endometriosis on quality of life and mental health: pelvic pain makes the difference. Journal of Psychosomatic Obstetrics & Gynecology. 2015;36(4):135-141. https://doi.org/10.3109/0167482X.2015.1074173
  7. Simoens S, Dunselman G, Dirksen C, Hummelshoj L, Bokor A, Brandes I, Brodszky V, Canis M, Colombo GL, DeLeire T, Falcone T, Graham B, Halis G, Horne A, Kanj O, Kjer JJ, Kristensen J, Lebovic D, Mueller M, Vigano P, Wullschleger M, D’Hooghe T. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Human Reproduction. 2012;27(5):1292-1299. https://doi.org/10.1093/humrep/des073
  8. Davidov AI, Tchaban OV. Endometriomas (endometrioid cysts) of ovaries: malignization risk, its causes and prophylactic measures. Onkoginekologiya. 2012;(2):39-48. (In Russ.)
  9. Sidorova IS, Unanyan AL, Kogan EA. Recurrent and non-recurrent endometriosis of the ovaries: clinical and pathogenetic mechanisms. Effektivnaya farmakoterapiya. 2011;(2):38-42. (In Russ.)
  10. Chegura SB. Endometriosis is «a familiar stranger». Choice of tactics for conducting women with this pathology. Meditsinskie aspekty zdorov’ya zhenshchiny. 2013;(9):25-37. (In Russ.)
  11. Marinho MCP, Magalhaes TF, Fernandes LFC, Augusto KL, Brilhante AVM, Bezerra LRPS. Quality of life in women with endometriosis: an integrative review. Journal of Women’s Health. 2018;27(3):399-408. https://doi.org/10.1089/jwh.2017.6397
  12. Ottolina J, Bartiromo L, Viganò P, Makieva S, Schimberni M, Candiani M. Does endometriosis influence the age of menopause? Minerva Ginecologica. 2018;70(2):171-177. https://doi.org/10.23736/S0026-4784.17.04125-9
  13. Avramenko NV. Endometriosis: pathogenesis, classification, diagnosis, modern aspects of therapy. Patologiya. 2014;2(31):4-11. (In Russ.)
  14. Kachalina TS, Semerikova MV, Strongin LG. Modern ideas of the pathogenesis of external genital endometriosis. Sovremennye tekhnologii v meditsine. 2011;(1):117-122. (In Russ.)
  15. Larosa M, Facchini F, Pozzoli G, Leone M, Grande M, Monica B. Endometriosis: aetiopathogenetic basis. Urologia. 2010;77(17):1-11.
  16. Cho YJ, Lee SH, Park JW, Han M, Park MJ, Han SJJ. Dysfunctional signaling underlying endometriosis: current state of knowledge. Journal of Molecular Endocrinology. 2018;60(3):R97-R113. https://doi.org/10.1530/JME-17-0227
  17. Ping S, Ma C, Liu P, Yang L, Yang X, Wu Q, Zhao X, Gong B. Molecular mechanisms underlying endometriosis pathogenesis revealed by bioinformatics analysis of microarray data. Archives of Gynecology and Obstetrics. 2016;293(4):797-804 https://doi.org/10.1007/s00404-015-3875-y
  18. Komorowska B. Autoimmune premature ovarian failure. Przeglad Menopauzalny. 2016;15(4):210-214. https://doi.org/10.5114/pm.2016.65666
  19. Yarmolinskaya MI, Tsitskarava DZ, Selkov SA. Cytokins as the markers for non-invasive diagnosis of pelvic endometriosis. Zhurnal akusherstva i zhenskikh bolezney. 2015;64(6):6-16. (In Russ.)
  20. Ahn SH, Monsanto SP, Miller C, Singh SS, Thomas R, Tayade C. Pathophysiology and Immune dysfunction in endometriosis. BioMed Reseachrch International. 2015;2015:795976. https://doi.org/10.1155/2015/795976
  21. Fan YY, Chen HY, Chen W, Liu YN, Fu Y, Wang LN. Expression of inflammatory cytokines in serum and peritoneal fluid from patients with different stages of endometriosis. Gynecological Endocrinology. 2018;34(6):507-512. https://doi.org/10.1080/09513590.2017.1409717
  22. Avanesova TG, Levkovich MA, Ermolova NV. The change in the phenotype of cytotoxic T lymphocytes and NK cells in external genital endometriosis. Materialy kongressa «XI Mezhdunarodnyy kongress po reproduktivnoy meditsine». M. 2017;59-61. Accessed December 17, 2018. (In Russ.). Available at:] http://reproductive-congress.ru/library.php
  23. Fazleabas AT, Braundmeier A, Parkin K. Endometriosis-induced changes in regulatory T-cells — insights towards developing permanent contraception. Contraception. 2015;92(2):116-119. https://doi.org/10.1016/j.contraception.2015.06.006
  24. Jeung I, Cheon K, Kim MR. Decreased cytotoxicity of peripheral and peritoneal natural killer cell in endometriosis. BioMed Reseachrch International. 2016;2016:2916070. https://doi.org/10.1155/2016/2916070
  25. Kang YJ, Jeung IC, Park A, Park YJ, Jung H, Kim TD, Lee HG, Choi I, Yoon SR. An increased level of IL-6 suppresses NK-cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression. Human Reproduction. 2014;29(10):2176-2189. https://doi.org/10.1093/humrep/deu172
  26. Tariverdian N, Siedentopf F, Rücke M, Blois SM, Klapp BF, Kentenich H, Arck PC. Intraperitoneal immune cell status in infertile women with and without endometriosis. Journal of Reproductive Immunology. 2009;80(1-2):80-90. https://doi.org/10.1016/j.jri.2008.12.005
  27. Thiruchelvam U, Wingfield M, O’Farrelly C. Increased uNK Progenitor cells in women with endometriosis and infertility are associated with low levels of endometrial stem cell factor. American Journal of Reproductive Immunology. 2016;75(4):493-502. https://doi.org/10.1111/aji.12486
  28. Shao J, Zhang B, Yu JJ, Wei CY, Zhou WJ, Chang KK, Yang HL, Jin LP, Zhu XY, Li MQ. Macrophages promote the growth and invasion of endometrial stromal cells by downregulating IL-24 in endometriosis. Reproduction. 2016;152(6):673-682. https://doi.org/10.1530/REP-16-0278
  29. Takebayashi A, Kimura F, Kishi Y, Ishida M, Takahashi A, Yamanaka A, Wu D, Zheng L, Takahashi K, Suginami H, Murakami T. Subpopulations of macrophages within eutopic endometrium of endometriosis patients. American Journal of Reproductive Immunology. 2015;73(3):221-231. https://doi.org/10.1111/aji.12331
  30. Zainetdinova LF, Telesheva LF, Koryaushkina AV. Functional activity of peritoneal macrophages and neutrophilis in various forms of external genital endometriosis. Vestnik Ural’skoy meditsinskoy akademicheskoy nauki. 2012;4(41):113-114. (In Russ.)
  31. Milewski Ł, Dziunycz P, Barcz E, Radomski D, Roszkowski PI, Korczak-Kowalska G, Kamiński P, Malejczyk J. Increased levels of human neutrophil peptides 1, 2, and 3 in peritoneal fluid of patients with endometriosis: association with neutrophils, T-cells and IL-8. Journal of Reproductive Immunology. 2011;91(1-2):64-70. https://doi.org/10.1016/j.jri.2011.05.008
  32. Aleksanova EM, Aksenenko VA, Pilavova OM. Local immunity changes in patients with endometrioid ovarian cysts on the background of undifferentiated connective tissue dysplasia. Fundamental’nye issledovaniya . 2014;10-2:245-250. (In Russ.)
  33. Hassa H, Tanir HM, Tekin B, Kirilmaz SD, Sahin Mutlu F. Cytokine and immune cell levels in peritoneal fluid and peripheral blood of women with early- and late-staged endometriosis. Archives of Gynecology and Obstetrics. 2009;279(6):891-895. https://doi.org/10.1007/s00404-008-0844-8
  34. Riccio LDGC, Santulli P, Marcellin L, Abrão MS, Batteux F, Chapron C. Immunology of endometriosis. Best Practice & Research Clinical Obstetrics & Gynaecology. 2018;2018;pii: S1521-6934(18):30028-2. https://doi.org/10.1016/j.bpobgyn.2018.01.010
  35. Thiruchelvam U, Wingfield M, O’Farrelly C. Natural Killer Cells: Key Players in Endometriosis. American Journal of Reproductive Immunology. 2015;74(4):291-301. https://doi.org/10.1111/aji.12408
  36. Jeung IC, Chung YJ, Chae B, Kang SY, Song JY, Jo HH, Lew YO, Kim JH, Kim MR. Effect of helixor A on natural killer cell activity in endometriosis. International Journal of Medical Science. 2015;12(1):42-47. https://doi.org/10.7150/ijms.10076.-48
  37. Li MQ, Wang Y, Chang KK, Meng YH, Liu LB, Mei J, Wang Y, Wang XQ, Jin LP, Li DJ. CD4+Foxp3+ regulatory T-cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic lesions. Cell Death and Disease. 2014;5:e1436. https://doi.org/10.1038/cddis.2014.414
  38. Zainetdinova LF, Telesheva LF, Koryaushkina AV, Kvyatkovskaya SV, Dvorchik EE. The state of systemic and tissue immunity at endometriosis genitalis externa depending on present or absent genital infectious agents. Vestnik Yuzhno-Ural’skogo gosudarstvennogo universiteta. Seriya: Obrazovanie, zdravookhranenie, fizicheskaya kul’tura. 2015;15(2):58-64. (In Russ.) https://doi.org/10.14529/ozfk150210
  39. Privalova EE, Medvedev BI, Zainetdinova LF. Clinico-immunological characteristics of patients with external genital endometriosis. Vestnik Yuzhno-Ural’skogo gosudarstvennogo universiteta. Seriya: Obrazovanie, zdravookhranenie, fizicheskaya kul’tura. 2008;19(199):105-108. (In Russ.)
  40. Herington JL, Bruner-Tran KL, Lucas JA, Osteen KG. Immune interactions in endometriosis. Expert Review of Clinical Immunology. 2011;7(5):611-626. https://doi.org/10.1586/eci.11.53
  41. Illanes SE, Maisey K, Sandoval M, Reyes FE, Figueroa-Gaete C, Pérez-Sepúlveda A, Busquets M, González P, Imarai M. Fas ligand (+) fallopian tube epithelium induces apoptosis in both Fas receptor (+) T lymphocytes and endometrial cells. Fertility and Sterility. 2013;100(2):550-560. https://doi.org/10.1016/j.fertnstert.2013.04.013
  42. Hsiao KY, Wu MH, Tsai SJ. Epigenetic regulation of the pathological process in endometriosis. Reproductive Medicine and Biology. 2017;16(4):314-319. https://doi.org/10.1002/rmb2.12047
  43. Nisenblat V, Bossuyt PM, Shaikh R, Farquhar C, Jordan V, Scheffers CS, Mol BW, Johnson N, Hull ML. Blood biomarkers for the non-invasive diagnosis of endometriosis. The Cochrane Database of Systematic Reviews (CDSR). 2016;(5):CD012179. https://doi.org/10.1002/14651858
  44. Vasilenko IA, Kardashova DZ, Tychinsky VP, Vishenskaya TV, Lifenko RA, Valov AL, Ivanyuta IV, Agadzhanyan BYa. Cellular diagnostics: the possibilities of vital computer microscopy. Vestnik poslediplomnogo meditsinskogo obrazovaniya. 2009;3-4:64. (In Russ.)
  45. Gasparyan SA, Popova OS, Vasilenko IA, Khripunova AA, Metelin VB. Evaluation of the lymphocyte interphase nuclei phenotype by quantitative phase imaging (QPI) in patients with endometrial ovarian cysts. Al’manakh klinicheskoy meditsiny. 2017;45(2):109-117. (In Russ.) https://doi.org/10.18786/2072-0505-2017-45-2-109-117
  46. Fukui A, Kamoi M, Funamizu A, Fuchinoue K, Chiba H, Yokota M, Fukuhara R, Mizunuma H. NK-cell abnormality and its treatment in women with reproductive failures such as recurrent pregnancy loss, implantation failures, preeclampsia, and pelvic endometriosis. Reproductive Medicine and Biology. 2015;14(4):151-157. https://doi.org/10.1007/s12522-015-0207-7
  47. Sikora J, Mielczarek-Palacz A, Kondera-Anasz Z. Role of natural killer cell activity in the pathogenesis of endometriosis. Current Medicinal Chemistry. 2011;18(2):2000-2008.
  48. Laganà AS, Triolo O, Salmeri FM, Granese R, Palmara VI, Ban Frangež H, Vrtčnik Bokal E, Sofo V. Natural Killer T cell subsets in eutopic and ectopic endometrium: a fresh look to a busy corner. Archives of Gynecology and Obstetrics. 2016;293(5):941-949. https://doi.org/10.1007/s00404-015-4004-7
  49. de Barros IBL, Malvezzi H, Gueuvoghlanian-Silva BY, Piccinato CA, Rizzo LV, Podgaec S. «What do we know about regulatory T cells and endometriosis? A systematic review». Journal of Reproductive Immunology. 2017;120:48-55. https://doi.org/10.1016/j.jri.2017.04.003
  50. Tanaka Y, Mori T, Ito F, Koshiba A, Takaoka O, Kataoka H, Maeda E, Okimura H, Mori T, Kitawaki J. Exacerbation of Endometriosis Due To Regulatory T-Cell Dysfunction. The Journal of Clinical Endocrinology & Metabolism. 2017;102(9):3206-3217. https://doi.org/10.1210/jc.2017-00052

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.