ABSTRACT Surgical treatment of ovarian endometrioimas is associated with the high risk of reducing ovarian reserve. This is due to both the negative effect of the tumor itself and the damage to the ovarian tissue because of use of bipolar coagulation. An alternative to bipolar coagulation may be the use of hemostatic matrices. The goal was to evaluate the efficacy and safety of using hemostatic matrices in laparoscopic cystovariectomy of endometriomas, to determine the possibility of maintaining ovarian reserve in such patients compared to bipolar coagulation. Material and methods. The study involved 45 patients aged 25—35 years. Criteria for inclusion in the study: the presence of an endometrioma in one of the ovaries with a maximum size of more than 3.0 cm, the absence of previous operations on the pelvic organs, the level of anti-Muller hormone (AMH) before the more than 2.0 ng/ml. Exclusion criteria: blood coagulation disorders and tumor localization in the area of the mesentery of the ovary. Patients were divided into 2 groups. The main group consisted of 30 patients in whom hemostasis was achieved using hemostatic matrices. The main group was divided into 3 subgroups. In subgroup 1 «Hemoblock» (OOO «Pul-SAR», Russia) was used, in subgroup 2 — Surgiflo («Ethicon Johnson&Johnson», USA), and in subgroup 3 Surgicel («Ethicon Johnson&Johnson», USA). The peculiarity of the operation was that before removing an ovarian tumor, a suspensorium ligament on the affected side was clamped with an atraumatic curved grasping forceps, CLICKLINE CROCE-OLMI («Karl Storz», Germany). The comparison group consisted of 15 patients in whom hemostasis was achieved by bipolar coagulation. Within 4 months after the operation patients were treated with gonadotropin-releasing hormone agonists (Buserelin-depo, «Pharmsynthez», Russia) at a dose of 3.75 mg. Before surgery, as well as after the restoration of menstruation after surgery, an ultrasound examination of the pelvic organs were performed and the serum levels of FSH, LH, estradiol, AMH were determined. Results. There were no allergic reactions or infectious and inflammatory complications related to the use of hemostatic matrices in any case. In all three subgroups of the main group, there was a decrease in the level of AMH, which, however, was not statistically significant. In the comparison group, the decrease in AMG level was statistically significant: 3.1±0.6 before treatment and 1.3±0.26 after treatment (p≤0.05). At the same time, the level of AMH in the comparison group was statistically significantly lower than in the subgroups of patients of the main group (3.1±0.36 in subgroup 1, p<0.01; 2.6±0.2 in subgroup 2, p<0.01; 2.3±0,24, in subgroup 3, p<0.05). Conclusion. The use of hemostatic matrices in the surgical treatment of ovarian endometriomas is an effective technique which may preserve the ovarian reserve.