Biomarkers of endometriosis: problems and possibilities of early detection of disease recurrence (a review)

Close metadata

Recommended articles:

Endometriosis and genital malformations in children and adolescents. What do they have in common?. Russian Journal of Human Reproduction. 2024;(3):14-22

Benign breast diseases in the focus of proliferative pathology of the reproductive system. Russian Journal of Human Reproduction. 2024;(3):33-42

Pharmacological prevention of fibrosis in dacryosurgery. Russian Annals of Ophthalmology. 2024;(2-2):180-189

The results of clinical application of the mesh with anti-adhesive fluoropolymer coating in laparoscopic intraperitoneal repair of primary ventral hernia. Pirogov Russian Journal of Surgery. 2024;(5):86-94

Electroencephalography: features of the obtained data and its applicability in psychiatry. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5):31-39

Maintenance immunosuppressive therapy for Crohn’s disease: patient adherence and its impact on treatment efficacy. Case report. Russian Journal of Evidence-Based Gastroenterology. 2024;(2):90-96

Experience of combined treatment of patients with infertility operated for external genital endometriosis. Russian Bulletin of Obstetrician-Gynecologist. 2024;(3):77-81

Predicting the risk of decreased ovarian reserve after surgical treatment of patients with deep infiltrative endometriosis using artificial intelligence. Russian Bulletin of Obstetrician-Gynecologist. 2024;(3):92-102

Epidemiological features of laryngeal papillomatosis in adults in Moscow. Russian Bulletin of Otorhinolaryngology. 2024;(3):4-10

Correlation dependence of tissue inhibitor of metalloproteinase-1 levels and follicular fluid morphology in patients with combined (uterine myoma and endometriosis) infertility in the ART-programs. Russian Bulletin of Obstetrician-Gynecologist. 2024;(4):21-28

ABSTRACT Endometriosis is a process associated with the displacement of endometrial tissue to extrauterine locations on morphological and functional characteristics similar to endometrium. It affects approximately 10% of women of reproductive age, causing considerable health problems and worsening reproductive outcomes. Infertility and pelvic pain, associated with endometriosis is global socioeconomic problem. There is no consensus about etiology, pathogenesis and methods of early detection this disease. Many studies of the molecular and genetic mechanisms responsible for the development of endometriosis promote the discovery of new aspects of the pathogenesis of endometriosis and help in the development of minimally invasive diagnostic methods. But so far laparoscopy remains the gold standard for the diagnosis of endometriosis. The discovery of a sufficiently sensitive and specific biomarker for the nonsurgical detection of endometriosis promises earlier diagnosis and prevention disease at an early stage. The analysis of the available researches of noninvasive diagnostic biomarkers of endometriosis in various biological environments will be presented in this review.

Keywords:

endometriosis

recurrence

infertility

pelvic pain

biomarkers

Authors:

Mezhlumova N.A.

National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Moscow, Russia

Bobrov M.Yu.

Federal State Budget Institution «Research Center for Obstetrics, Gynecology and Perinatology» Ministry of Healthcare of the Russi, Moscow, Russia, 117997

Adamyan L.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

SPIN RSCI: 9836-2713
Scopus AuthorID: 7006372422
ResearcherID: Q-1722-2018
ORCID: 0000-0002-3253-4512

List of references:

Adamson G.D. Endometriosis fertility index: the new, validated endometriosis staging system. Fertility and Sterility. 2010;94(5):1609-1615. https://doi.org/10.1016/j.fertnstert.2009.09.035
Adamyan LV, Gasparyan SA. Genital’nyj ehndometrioz. Sovremennyj vzglyad na problemu. Monografiya. Stavropol’: SSMA; 2004. (In Russ.)
Adamyan LV, Kulakov VI, Andreeva EN. Ehndometriozy. Rukovodstvo dlya vrachej. Izd. 2-e. M: Meditsina; 2006. (In Russ.)
Adamyan LV. Clinic, diagnostics and treatment of genital endometriosis. Akusherstvo i ginekologiya. 1992;7:54-59. (In Russ.)
Adamyan LV. Ehndometriozy. Rukovodstvo dlya vrachej. M.: Medicina; 1998. (In Russ.)
American Society for Reproductive Medicine. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertility and Sterility. 1997;67(5):817-821. https://doi.org/10.1016/S0015-0282(97)81391-X
Giudice LC. Endometriosis. New England Journal of Medicine. 2010;362:2389-2398. https://doi.org/10.1056/NEJMcp1000274
Nnoaham KE, Hummelshoj L, Kennedy SH, Jenkinson C, Zondervan KT; World Endometriosis Research Foundation Women’s Health Symptom Survey Consortium. Developing symptom-based predictive models of endometriosis as a clinical screening tool: results from a multicenter study. Fertility and Sterility. 2012;98(3):692-701. https://doi.org/10.1016/j.fertnstert.2012.04.022
Iglesias C, Banker M, Mahajan N, Herrero L, Meseguer M, Garcia-Velasco JA. Ethnicity as a determinant of ovarian reserve: Differences in ovarian aging between Spanish and Indian women. Fertility and Sterility. 2014;102(1):244-249. https://doi.org/10.1016/j.fernstert.2014.03.050
Adamyan LV, Andreeva EN, Apolikhina IA, Bezhenar VF, Gevorkyan MA, Gus AI, Demidov VN, Kalinina EA, Levakov SA, Marchenko LA, Popov AA, Sonova MM, Khashukoyeva AZ, Chernukha GE, Yarotskaya EL. Ehndometrioz: diagnostika, lechenie i reabilitaciya. Federal’nye klinicheskie rekomendacii po vedeniyu bol’nyh. M.: Rossiĭskoe obshchestvo akusherov-ginekologov; 2013. (In Russ.)
Adamyan LV, Kurilo LF, Shulyak IYu. Ovarian folliculogenesis in women with some forms of endometriosis. Problemy reproduktsii. 2009;15(1):78-85. (In Russ.)
May KE, Conduit-Hulbert SA, Villar J, Kirtley S, Kennedy SH, Becker CM. Peripheral biomarkers of endometriosis: a systematic review. Human Reproduction Update. 2010;16(6):651-674. https://doi.org/10.1093/humupd/dmq009
May KE, Villar J, Kirtley S, Kennedy SH, Becker CM. Endometrial alterations in endometriosis: A systematic review of putative biomarkers. Human Reproduction Update. 2011;17(5):637-653. https://doi.org/10.1093/humupd/dmr013
Nisenblat V, Prentice L, Bossuyt PM, Farquhar C, Hull ML, Johnson N. Combination of the non-invasive tests for the diagnosis of endometriosis (review). The Cochrane Database of Systematic Reviews. 2016;7:CD012281. https://doi.org/10.1002/14651858.cd012281
Vicente-Muñoz S, Morcillo I, Puchades-Carrasco L, Payá V, Pellicer A, Pineda-Lucena A. Pathophysiologic processes have an impact on the plasma metabolomic signature of endometriosis patients. Fertility and Sterility. 2016;106(7):1733-1741. https://doi.org/10.1016/j.fertnstert.2016.09.014
Vicente-Muñoz S, Morcillo I, Puchades-Carrasco L, Payá V, Pellicer A, Pineda-Lucena A. Nuclear magnetic resonance metabolomic profiling of urine provides a noninvasive alternative to the identification of biomarkers associated with endometriosis. Fertility and Sterility. 2015;104(5):1202-1209. https://doi.org/10.1016/j.fertnstert.2015.07.1149
Vodolazkaia A, El-Aalamat Y, Popovic D, Mihalyi A, Bossuyt X, Kyama CM, Fassbender A, Bokor A, Schols D, Huskens D, Meuleman C, Peeraer K, Tomassetti C, Gevaert O, Waelkens E, Kasran A, De Moor B, D’Hooghe TM. Evaluation of a panel of 28 biomarkers for the non-invasive diagnosis of endometriosis. Human Reproduction. 2012;27(9):2698-2711. https://doi.org/10/1093/humrep/des234
Kyama CM, Mihalyi A, Gevaert O, Waelkens E, Simsa P, Van de Plas R, Meuleman C, De Moor B, D’Hooghe TM. Evaluation of endometrial biomarkers for semi-invasive diagnosis of endometriosis. Fertility and Sterility. 2011;95(4):1338-1343. https://doi.org/10.1016/j.fertnstert.2010.06.084
Becker CM, D’Amato RJ. Angiogenesis and antiangiogenic therapy in endometriosis. Microvasc Research. 2007;74:121-130. https://doi.org/10.1186/1756-9966-29-4
Singh AK, Chattopadhyay R, Chakravarty B, Chaudhury K. Altered circulating levels of matrix metalloproteinases 2 and 9 and their inhibitors and effect of progesterone supplementation in women with endometriosis undergoing in vitro fertilization. Fertility and Sterility. 2013;100(1):127-134. https://doi.org/10.1093/humrep/des234
Xavier P, Belo L, Beires J, Rebelo I, Martinez-de-Oliveira J, Lunet N, Barros H. Serum levels of VEGF and TNF-alpha and their association with C-reactive protein in patients with endometriosis. Archives of Gynecology and Obstetrics. 2006;273(4):227-231. https://doi.org/10.1038/sj.bjc.6603150
Bourlev V, Iljasova N, Adamyan L, Larsson A, Olovsson M. Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometri osis. Fertility and Sterility. 2010;94(1):52-57. https://doi.org/10.1016/j.fertnstert.2013.01.097
Hapangama DK, Turner MA, Drury JA, Quenby S, Martin-Ruiz C. Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length. Fertility and Sterility. 2008;23(7):1511-1519. https://doi.org/10.1016/j.fertnstert. 2013.01.097
Kalu E, Sumar N, Giannopoulos T, Patel P, Croucher C, Sherriff E, Bansal A. Cytokine profiles in serum and peritoneal fluid from infertile women with and without endometriosis. The Journal of Obstetrics and Gynaecology Research. 2007;33:490-495. https://doi.org/10.1093/humupd/5.2.153
Socolov R, Butureanu S, Angioni S, Sindilar A, Boiculese L, Cozma L, Socolov D. The value of serological markers in the diagnosis and prognosis of endometriosis: a prospective case-control study. European Journal of Obstetric, Gynecology, and Reproductive Biology. 2011;154(2):215-217. https://doi.org/10.1016/j.ejogrb.2010.10.008
Othman EEDR, Homung D, Salem HT, Khalifa EA, El-Metwally TH, Al-Hendy A. Serum cytokines as biomarkers for nonsurgical prediction of endometriosis. European Journal of Obstetric, Gynecology, and Reproductive Biology. 2008;137(2):240-246.
Ercan C, Sakinci M. Antimullerian hormone levels after laparoscopic endometrioma. Gynecological Endocrinology. 2010;26(6):468-472. https://doi.org/10.3109/09513591003632134
Mihalyi A, Gevaert O, Kyama CM, Simsa P, Pochet N, De Smet F, De Moor B, Meuleman C, Billen J, Blanckaert N, Vodolazkaia A, Fulop V, D’Hooghe TM. Non-invasive diagnosis of endometriosis based on a combined analysis of six plasma biomarkers. Human Reproduction. 2010;25(3):654-664. https://doi.org/10.3109/09513591003632134
Kocbek V, Vouk K, Mueller MD, Rižner TL, Bersinger N. Elevated glycodelin-A concentrations in serum and peritoneal fluid of women with ovarian endometriosis. Gynecol Endocrinol. 2013;29(5):455-459. https://doi.org/10.3109/09513590.2013.769516
Burney RO, Hamilton AE, Aghajanova L, Vo KC, Nezhat CN, Lessey BA, Giudice LC. MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis. Molecular Human Reproduction. 2009;15:625-631. https://doi.org/10.1093/molehr/gap068
Seppala MKH, Koistinen R, Hautala L, Chiu PC, Yeung WS. Glycodelin in reproductive endocrinology and hormone-related cancer. European Journal of Endocrinology. 2009;160(2):121-133. https://doi.org/10.1095/biolreprod.114.127381
Kim VN. Small RNAs: classification, biogenesis, and function. Molecular Cells. 2005;19:1-15.
Jia SZ, Yang Y, Lang J, Sun P, Leng J. Plasma miR-17-5p, miR-20a and miR-22 are downregulated in women with endometriosis. Human Reproduction. 2013;28(2):322-330. https://doi.org/10.1210/me.2010-0371
Suryawanshi S, Vlad AM, Lin HM, Mantia-Smaldone G, Laskey R, Lee M, Lin Y, Donnellan N, Klein-Patel M, Lee T, Mansuria S, Elishaev E, Budiu R, Edwards RP, Huang X. Plasma microRNAs as novel biomarkers for endometriosis and endometriosis-associated ovarian cancer. Clinical Cancer Research. 2013;19(5):1213-1224. https://doi.org/10.1158/1078-0432.CCR-13-0561
Meola J, Hidalgo Gdos S, Silva JC, Silva LE, Ra F. Caldesmon: new insights for diagnosing endometriosis. Biology of Reproduction. 2013;88(5):122. https://doi.org/10.1095/biolreprod.112.103598
Polak G, Wertel I, Barczyński B, Kwaśniewski W, Bednarek W, Kotarski J. Increased levels of oxidative stress markers in the peritoneal fluid of women with endometriosis. European Journal of Obstetrics, Gynecology and Reproductive Biology. 2013;168(2):187-190. https://doi.org/10.1371/journal.pone.0098174
Yun BH, Lee YS, Chon SJ, Jung YS, Yim SY, Kim HY, Park JH, Seo SK, Cho S, Choi YS, Lee BS. Evaluation of elevated urinary enolase I levels in patients with endometriosis. Biomarkers. 2014;19(1):16-21. https://doi.org/10.3109/1354750x.2013.863973
Cho S, Choi YS, Yim SY, Yang HI, Jeon YE, Lee KE. Urinary vitamin D-binding protein is elevated in patients with endometriosis. Human Reproduction. 2012;27(2):515-522. https://doi.org/10.1093/humrep/der34
Cho SH, Oh YJ, Nam A, Kim HY, Park JH, Kim JH, Park KH, Cho DJ, Lee BS. Evaluation of serum and urinary angiogenic factors in patients with endometriosis. American Journal of Reproductive Immunology. 2007;58(6):497-504. https://doi.org/10.1111/j.1600-0897.2007.00535
Grande G, Vincenzoni F, Milardi D, Pompa D, Ricciardi D, Fruscella E, Mancini F, Pontecorvi A, Castagnola M, Marana R. Cervical mucus proteome in endometriosis. Clinical Proteomics. 2017; 14(1):7. https://doi.org/10.1186/s12014-017-9142-4
Wingeld M, O’Herilhy C, Finn MM, Tallon DF, Fottrell PF. Follicular and luteal phase salivary progesterone in women with endometriosis and infertility. Gynecological Endocrinology. 1994;8(1):21-25. https://doi.org/10.1016/j.ejogrb.2007.05.001
Petrelluzzi KF, Garcia MC, Petta CA, Grassi-Kassisse DM, Spadari-Bratsch R. Salivary cortisol concentrations and quality of life in women with endometriosis and chronic pelvic pain. Stress. 2008;11(5):390-397. https://doi.org/10.1080/10253890701840610
Becker CM, Laufer MR, Stratton P, Hummelshoj L, Missmer SA, Zondervan KT, Adamson GD; WERF EPHect Working Group. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: I. Surgical phenotype data collection in endometriosis research. Fertility and Sterility. 2014;102(5):1213-1222. https://doi.org/10.1016/j.fertnstert.2014.07.709
Rahmioglu N, Fassbender A, Vitonis AF, Tworoger SS, Hummelshoj L, D’Hooghe TM, Adamson GD, Giudice LC, Becker CM, Zondervan KT, Missmer SA; WERF EPHect Working Group. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: III. Fluid biospecimen collection, processing, and storage in endometriosis research. Fertility and Sterility. 2014;102(5):1233-1243. https://doi.org/10.1016/j.fertnstert.2005.08.017
Burghaus S, Fehm T, Fasching PA, Blum S, Renner SK, Baier F, Brodkorb T, Fahlbusch C, Findeklee S, Häberle L, Heusinger K, Hildebrandt T, Lermann J, Strahl O, Tchartchian G, Bojahr B, Porn A, Fleisch M, Reicke S, Füger T, Hartung CP, Hackl J, Beckmann MW, Renner SP. The International Endometriosis Evaluation Program (IEEP study) — a systematic study for physicians, researchers and patients. Geburtshilfe und Frauenheilkunde. 2016;76(8):875-881. https://doi.org/10.1055/s-0042-106895

Close metadata