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Shcherbakov V.I.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Pozdniakov I.M.

Novosibirskiĭ gorodskoĭ perinatal'nyĭ tsentr

Shirinskaya A.V.

Federal State Budget Institute of Experimental and clinical Medicine, Novosibirsk, Russia, State Education Institution of Higher Professional Education, Novosibirsk State Medical University of the Ministry of Public Health of Russia, Novosibirsk, Russia, 630091

Volkov M.V.

Federal State Research Institution of Experimental and Clinical Medicine, 630117, city of Novosibirsk, 2 Timakova Str., State Educational Institution of Higher Professional Education Novosibirsk State Medical University of the Ministry of Public Health of Russia, 630091 Novosibirsk, 52 Krasny Prospect, Novosibirsk, Russia

Gordienko O.V.

Federal State Research Institution of Experimental and Clinical Medicine, 630117, city of Novosibirsk, 2 Timakova Str., State Educational Institution of Higher Professional Education Novosibirsk State Medical University of the Ministry of Public Health of Russia, 630091 Novosibirsk, 52 Krasny Prospect, Novosibirsk, Russia

Leptin, Interleukin-6, soluble receptors for VEGF and oxidized LDL in pregnancies complicated preeclampsia, premature delivery risk, obesity

Authors:

Shcherbakov V.I., Pozdniakov I.M., Shirinskaya A.V., Volkov M.V., Gordienko O.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2018;24(3): 88‑95

DOI: 10.17116/repro201824388

Read: 1215 times

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Table of contents

LEPTIN, INTERLEUKIN-6, SOLUBLE RECEPTORS FOR VEGF AND OXIDIZED LDL IN PREGNANCIES COMPLICATED PREECLAMPSIA, PREMATURE DELIVERY RISK, OBESITY
LEPTIN, INTERLEUKIN-6, SOLUBLE RECEPTORS FOR VEGF AND OXIDIZED LDL IN PREGNANCIES COMPLICATED PREECLAMPSIA, PREMATURE DELIVERY RISK, OBESITY

To cite this article:

Shcherbakov VI, Pozdniakov IM, Shirinskaya AV, Volkov MV, Gordienko OV. Leptin, Interleukin-6, soluble receptors for VEGF and oxidized LDL in pregnancies complicated preeclampsia, premature delivery risk, obesity. Russian Journal of Human Reproduction. 2018;24(3):88‑95. (In Russ.)
https://doi.org/10.17116/repro201824388

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objective — to present the data of the parallel detection of leptin, IL-6, soluble receptors for VEGF and oxidized LDL in blood serum in case of pregnancy with preeclampsia, premature delivery risk, obesity. Material and methods. 78 pregnant women were examined: 21 patient with preeclampsia (group 1), 17 women with premature delivery risk (group 2), 15 patents with obesity without arterial hypertension (group 3) and 25 healthy pregnant women (group 4). Results. The common issue of all these conditions is inflammation. It turned out that in all three conditions the level of leptin was increased, but obesity was related to the highest values. The reason is that the placenta leptin and the fatty tissue leptin are summed up and result in such high values. Interleukin-6 was increased in case of preeclampsia, it tended upward in case of obesity and was within the normal range in case of the premature delivery risk. Soluble receptor 1 for VEGF was considerably increased in case of preeclampsia and reduced in case of premature delivery risk. Soluble receptor 1 for oxidized LDL was reduced to minimum in case of premature delivery risk and this value was the same as the control value in case of preeclampsia. Conclusion. We have come to the conclusion that all examined cytokines can be the mechanisms of the pathologic behavior, but their functional role can be different.

Keywords:

preeclampsia
premature delivery risk
obesity
pregnancy
cytokines

Authors:

Shcherbakov V.I.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Pozdniakov I.M.

Novosibirskiĭ gorodskoĭ perinatal'nyĭ tsentr

Shirinskaya A.V.

Federal State Budget Institute of Experimental and clinical Medicine, Novosibirsk, Russia, State Education Institution of Higher Professional Education, Novosibirsk State Medical University of the Ministry of Public Health of Russia, Novosibirsk, Russia, 630091

Volkov M.V.

Federal State Research Institution of Experimental and Clinical Medicine, 630117, city of Novosibirsk, 2 Timakova Str., State Educational Institution of Higher Professional Education Novosibirsk State Medical University of the Ministry of Public Health of Russia, 630091 Novosibirsk, 52 Krasny Prospect, Novosibirsk, Russia

Gordienko O.V.

Federal State Research Institution of Experimental and Clinical Medicine, 630117, city of Novosibirsk, 2 Timakova Str., State Educational Institution of Higher Professional Education Novosibirsk State Medical University of the Ministry of Public Health of Russia, 630091 Novosibirsk, 52 Krasny Prospect, Novosibirsk, Russia

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References:

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