Objective — to study the effectiveness of the use of native vitamin D (tableted cholecalciferol) in the total saturating and maintenance dose in patients with vitamin D deficiency or deficiency in normogonadotropic anovulation. Material and methods. The study included 48 women, a reproductive age with normogonadotropic anovulation and vitamin D deficiency or deficiency. Depending on the initial level of vitamin D in the blood serum, the patients were divided into 2 groups: I group included 28 women with a deficit vitamin D (level 25(OH)D 12.4±2.8 ng/ml); the second group included 20 women with vitamin D deficiency with a baseline level of 25(OH)D 22.8±2.1 ng/ml. Normogonadotropic anovulation was associated with PCOS in 20 women: with OGE in 16 women; in 12 women with chronic salpingo-oophoritis: 22 patients had excess body weight (BMI was 27.5±0.9 kg/m2). Patients from group I used 6,000 ED of tableted cholecalciferol daily; patients from Group II used 4000 U of tableted cholecalciferol daily for 8 weeks. Subsequently, patients of both groups were recommended a maintenance dose of tableted cholecalciferol daily at 2000 units for the next 8 weeks. Level 25(OH)D and progesterone in the blood serum were determined 2 and 4 months after the beginning of the use of tableted cholecalciferol. Results. Tableted cholecalciferol used in the total saturating and maintenance dose effectively eliminates vitamin D deficiency and insufficiency in patients with normogonadotropic anovulation. In 4 months from the beginning of the use of tableted cholecalciferol, the average level of 25(OH)D in the blood serum significantly increased by 89.2% and amounted to 34.5±4.9 ng/ml (p<0.05). Elimination of vitamin D deficiency, in combination with a low-calorie diet and dosed physical activity, promoted weight normalization in 40.9% of patients with excess body weight. The decrease in BMI in women with excess body weight significantly correlated with an increase in serum 25(OH)D (r =–0.42; p=0.05) and the dose of vitamin D. A significant decrease in weight by 10.3% the initial (p<0.05) was in patients of the I group. The level of progesterone in the serum after 4 months on the 20—23 day of the menstrual cycle increased to 7.3±3.3 nmol/l, but did not differ significantly from the initial 4.5±1.6 nmol/l. Conclusion. For effective treatment of normogonadotropic anovulation, elimination of vitamin D deficiency is considered as an important factor in reducing metabolic disorders in patients with PCOS, obesity or overweight.