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Chistiakova G.N.

FGBU "Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva", Ekaterinburg

Remizova I.I.

FGBU "Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva", Ekaterinburg

Kayumova A.V.

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia, Yekaterinburg, Russia

Dankova I.V.

Ural Research Institute of Maternal and Infant Care, Ministry of Health of the Russian Federation, Yekaterinburg, Russia

Melkozerova O.A.

Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva, Ekaterinburg

The markers of endothelia dysfunction in prediction of placental insufficiency at early pregnancy, induced by assisted reproductive technologies

Authors:

Chistiakova G.N., Remizova I.I., Kayumova A.V., Dankova I.V., Melkozerova O.A.

More about the authors

Journal: Russian Journal of Human Reproduction. 2017;23(6): 111‑115

DOI: 10.17116/repro2017236111-115

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THE MARKERS OF ENDOTHELIA DYSFUNCTION IN PREDICTION OF PLACENTAL INSUFFICIENCY AT EARLY PREGNANCY, INDUCED BY ASSISTED REPRODUCTIVE TECHNOLOGIES
THE MARKERS OF ENDOTHELIA DYSFUNCTION IN PREDICTION OF PLACENTAL INSUFFICIENCY AT EARLY PREGNANCY, INDUCED BY ASSISTED REPRODUCTIVE TECHNOLOGIES

To cite this article:

Chistiakova GN, Remizova II, Kayumova AV, Dankova IV, Melkozerova OA. The markers of endothelia dysfunction in prediction of placental insufficiency at early pregnancy, induced by assisted reproductive technologies. Russian Journal of Human Reproduction. 2017;23(6):111‑115. (In Russ.)
https://doi.org/10.17116/repro2017236111-115

 
Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objective — to determine the prognostic criteria for the development of placental insufficiency from early gestation period induced by ART. Material and methods. Clinical and laboratory examination of 17 women, whose pregnancy was complicated by subcompensated placental insufficiency (group 1) and 22 women without placental insufficiency, which do not deviate in biophysical profile according to ultrasound (2nd group) was carried out. The comparison group consisted of 34 women with a singleton spontaneous pregnancy. The content of vasculo-endothelial growth factor (VEGF) and its soluble receptor-1 (sVEGF-R1), the concentration of endoglene and endothelin-1 were evaluated by enzyme immunoassay. The level of stable metabolites of nitric oxide (endogenous nitrite, total nitrite and nitrate) was evaluated spectrophotometrically. Conclusion. Determination of renin content, endoglene concentration and sVEGF-R1 level in the serum of women in the first trimester, induced by ART of pregnancy, allows to increase the efficiency of the prognosis of placental insufficiency up to 88% in blood serum.

Keywords:

first trimester of pregnancy
assisted reproductive technologies
endothelial dysfunction
angiogenesis

Authors:

Chistiakova G.N.

FGBU "Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva", Ekaterinburg

Remizova I.I.

FGBU "Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva", Ekaterinburg

Kayumova A.V.

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia, Yekaterinburg, Russia

Dankova I.V.

Ural Research Institute of Maternal and Infant Care, Ministry of Health of the Russian Federation, Yekaterinburg, Russia

Melkozerova O.A.

Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva, Ekaterinburg

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References:

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