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Safarian G.Kh.

Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Obedkova K.V.

Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Komarova E.M.

Ott Research Institute of Obstetrics, Gynecology and Reproduction

Niauri D.A.

Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Gzgzyan A.M.

Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Tapilskaya N.I.

Ott Research Institute of Obstetrics, Gynecology and Reproduction

Bespalova O.N.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproduction

Prediction of pregnancy in ART cycles in Hashimoto’s thyroiditis affected women with antithyroid antibodies positivity

Authors:

Safarian G.Kh., Obedkova K.V., Komarova E.M., Niauri D.A., Gzgzyan A.M., Tapilskaya N.I., Bespalova O.N.

More about the authors

Journal: Russian Journal of Human Reproduction. 2025;31(3): 70‑76

DOI: 10.17116/repro20253103170

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Table of contents

PREDICTION OF PREGNANCY IN ART CYCLES IN HASHIMOTO’S THYROIDITIS AFFECTED WOMEN WITH ANTITHYROID ANTIBODIES POSITIVITY
PREDICTION OF PREGNANCY IN ART CYCLES IN HASHIMOTO’S THYROIDITIS AFFECTED WOMEN WITH ANTITHYROID ANTIBODIES POSITIVITY

To cite this article:

Safarian GKh, Obedkova KV, Komarova EM, Niauri DA, Gzgzyan AM, Tapilskaya NI, Bespalova ON. Prediction of pregnancy in ART cycles in Hashimoto’s thyroiditis affected women with antithyroid antibodies positivity. Russian Journal of Human Reproduction. 2025;31(3):70‑76. (In Russ.)
https://doi.org/10.17116/repro20253103170

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To determine the follicular fluid antithyroid antibodies in Hashimoto’s thyroiditis affected women undergoing ART treatment, and to develop a prognostic model for clinical efficacy improvement of infertility treatment in these patients.

MATERIAL AND METHODS

A prospective cohort comparative study of total 90 in vitro fertilization cycles was performed in Hashimoto’s thyroiditis affected women with antithyroid antibodies positivity (study group — 45 patients) and women without autoimmune thyroid disease (comparison group — 45 patients).

RESULTS

The following model has been developed: AT-TG FF ≤155 IU/ml — 2 points, AT-TPO FF ≤258 IU/ml — 3 points, the antral follicle count ≥9 — 2 points and the high-quality embryo presence characterized by blastocyst stage ≥3, inner cell mass type A and B and trophectoderm type A and B — 3 points predicts the clinical pregnancy in patients with infertility and Hashimoto’s thyroiditis with sensitivity of 82% and specificity of 77%.

CONCLUSION

Considering the high sensitivity and specificity and relative simplicity, the proposed model can be recommended for application in routine clinical practice of obstetricians-gynecologists and infertility specialists to improve the clinical efficacy of ART programs in women with infertility and Hashimoto’s thyroiditis.

Keywords:

Hashimoto’s thyroiditis
antibodies to thyroid peroxidase
antibodies to thyroglobulin
in vitro fertilization/intracytoplasmic sperm injection
clinical pregnancy
assisted reproductive technologies
follicular fluid

Authors:

Safarian G.Kh.

Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Obedkova K.V.

Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Komarova E.M.

Ott Research Institute of Obstetrics, Gynecology and Reproduction

Niauri D.A.

Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Gzgzyan A.M.

Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Tapilskaya N.I.

Ott Research Institute of Obstetrics, Gynecology and Reproduction

Bespalova O.N.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproduction

Received:

25.12.2023

Accepted:

29.05.2024

Close metadata

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