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Andreeva E.A.

Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia, 630099

Khonina N.A.

Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia, 630099

Pasman N.M.

Novosibirskiĭ gosudarstvennyĭ universitet

Chernykh E.R.

Research Institute of Fundamental and Clinical Immunology, 14 Yadrintsevskaya St., Novosibirsk, Russian Federation, 630099

Сytokins in the regulation of ovarian folliculogenesis (a review)

Authors:

Andreeva E.A., Khonina N.A., Pasman N.M., Chernykh E.R.

More about the authors

Journal: Russian Journal of Human Reproduction. 2017;23(1): 8‑14

DOI: 10.17116/repro20172318-14

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Table of contents

СYTOKINS IN THE REGULATION OF OVARIAN FOLLICULOGENESIS (A REVIEW)
СYTOKINS IN THE REGULATION OF OVARIAN FOLLICULOGENESIS (A REVIEW)

To cite this article:

Andreeva EA, Khonina NA, Pasman NM, Chernykh ER. Сytokins in the regulation of ovarian folliculogenesis (a review). Russian Journal of Human Reproduction. 2017;23(1):8‑14. (In Russ.)
https://doi.org/10.17116/repro20172318-14

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This review is devoted to the regulatory role of cytokines on the different stages of folliculogenesis, from primordial follicle development to oocyte maturation and ovulation. Disturbance of cytokine regulation is associated with reduced quality of oocyte and embryo implantation failure. The level of some cytokines (TGF-β1, LIF, GDF-9, G-CSF, IGF) in follicular fluid is associated with the maturity of the oocytes, the number and quality of embryos, as well as a positive outcome of an IVF cycle. Elevated levels of other cytokines (TNF-α, IL-1, IL-2, IL-6, IL-12, IL-17) may have negative affect on the IVF outcome and embryogenesis. Cytokine levels in the follicular fluid can be considered as a marker and predictor of IVF outcome.

Keywords:

infertility
folliculogenesis
oocyte
cytokines
IVF
follicular fluid

Authors:

Andreeva E.A.

Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia, 630099

Khonina N.A.

Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia, 630099

Pasman N.M.

Novosibirskiĭ gosudarstvennyĭ universitet

Chernykh E.R.

Research Institute of Fundamental and Clinical Immunology, 14 Yadrintsevskaya St., Novosibirsk, Russian Federation, 630099

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