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Burlev V.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

The role of endometrial blood vessels in the formation of the trophoblast and placenta

Authors:

Burlev V.A.

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Journal: Russian Journal of Human Reproduction. 2016;22(6): 8‑17

DOI: 10.17116/repro20162268-17

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Table of contents

THE ROLE OF ENDOMETRIAL BLOOD VESSELS IN THE FORMATION OF THE TROPHOBLAST AND PLACENTA
THE ROLE OF ENDOMETRIAL BLOOD VESSELS IN THE FORMATION OF THE TROPHOBLAST AND PLACENTA

To cite this article:

Burlev VA. The role of endometrial blood vessels in the formation of the trophoblast and placenta. Russian Journal of Human Reproduction. 2016;22(6):8‑17. (In Russ.)
https://doi.org/10.17116/repro20162268-17

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objectives — to systematize and present the most important current data on the early processes of neoangiogenesis and angiogenesis in the endometrium to nidation and after it and in the process of formation and functioning of the trophoblast and placenta. Material and methods. Database PubMed was searched using realincest key words to identify studies on the role of endometrial blood vessels in the formation of the trophoblast and placenta. Results. The literature data and the cycle of their own research on the role of endometrial blood vessels in the formation of the trophoblast and placenta indicates the presence of cause-effect relationships of balanced processes in the phenotypic-dependent functions of pregnancy and the lack thereof, when it is not offensive. The beginning of various events in the endometrium due to: the state of the endometrium to nidation, conversion of vessels in the uterus after nidation, formation of trophoblast and placenta, the condition of the vessels of the placenta. All these processes are based on biochemical cascades and changes of angiogenesis and associated regulatory systems. Conclusion. The use of data on the role of angiogenesis in the endometrium in the formation of the trophoblast and placenta indicate that the blood vessels of the endometrium are the triggers of the onset and maintenance of pregnancy.

Keywords:

eutopic endometrium
angiogenesis
trophoblast
placenta

Authors:

Burlev V.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

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References:

  1. Burlev VA. Svobodnoradikal'noe okislenie v sisteme mat'-placenta-plod pri akusherskoj patologii: Dis. ... d-ra med. nauk. М.1992;50. (In Russ.). Available at: http://medical-diss.com/medicina/svobodnoradikalnoe-okislenie-v-sisteme-mat-platsenta-plod-pri-akusherskoy-patologii Accessed June 27,2016
  2. Burlev VA. Proliferativnaja i angiogennaja aktivnost' jeutopicheskogo i jektopicheskogo jendometrija u bol'nyh s peritoneal'noj formoj jendometrioza. Problemy reproduktsii. 2006;1:78-87. (In Russ.). Available at: http://elibrary.ru/item.asp?id=21947357 Accessed June 27,2016
  3. Burlev VA. Autoparacrine impairments of angiogenesis regulation in proliferative forms of female reproductive diseases. Akusherstvo i ginekologija. 2006;3:34-40. (In Russ.). Available at: http://elibrary.ru/item.asp?id=9226321 Accessed June 27,2016
  4. Burlev VA. Angiogenesis inversion in pregnancy. Problemy reproduktsii. 2013;3:54-62. (In Russ.). Available at: http://elibrary.ru/item.asp?id=19119520 Accessed June 27,2016
  5. Burlev VA, Pavlovich SV. Angiogenez i angiogennye faktory rosta v reguljacii reproduktivnoj sistemy u zhenshhin. Probl Reproduktsii. 1999;5:6-13. (In Russ.). Available at: http://www.rusmedserv.com/problreprod/1999g/5/article_821.html Accessed June 27,2016
  6. Burlev VA, Zajdieva ZS, Tjutjunnik VL. Kliniko-diagnosticheskoe znachenie opredelenija faktora rosta placenty u beremennyh s hronicheskoj placentarnoj nedostatochnost'ju. Probl Reproduktsii. 2001;5:31-35. (In Russ.). Available at: http://www.rusmedserv.com/problreprod/2001g/5/article_903.html Accessed June 27,2016
  7. Burlev VA, Zaidieva ZS, Ilyasova NA. Angiogenesis of gestation regulation (a review). Probl Reproduktsii. 2008;3:18-22. (In Russ.). Available at: http://elibrary.ru/item.asp?id=11572554 Accessed June 27,2016
  8. Burlev VA, Zaydieva ZS, Kan NE, Ilyasova NA. The vascular-endothelial growth factor and soluble receptors in pregnant women with intrauterine infection of the fetus. Gynecology, Obstetrics and Perinatology. 2007;3:13-17. (In Russ.). Available at: http://old.phdynasty.ru/article/1134/ Accessed June 27,2016
  9. Burlev VA, Zaidieva ZS, Kan NE, Ilyasova NA, Burlev AV. Paraplacental angiogenesis in pregnant women with intrauterine infection. Probl Reproduktsii. 2008;5:59-63. (In Russ.). Available at: http://elibrary.ru/item.asp?id=11678738 Accessed June 27,2016
  10. Burlev VA, Zajdieva ZS, Tjutjunik VL, Kravchenko NF, Pavlovich SV, Konovodova EN. Rol' faktorov rosta v razvitii placentarnoj nedostatochnosti (obzor literatury). Probl Reproduktsii. 1999;6:7-12. (In Russ.). Available at: http://www.rusmedserv.com/problreprod/1999g/6/article_850.html Accessed June 27,2016
  11. Burlev VA, Ilyasova NA. The influence of LIF, LIF-Rα, gp130, SOCS1 pathways in the endometrium on pregnancy outcomes after IVF/ICSI in patients with tubal infertility. Problemy reproduktsii. 2015;5:49-57. (In Russ.). doi:10.17116/repro201521549-57
  12. Burlev VA, Ilyasova NA. Cluster of signaling pathway LIF/LIFR/gp130 activation in embryos during IVF/ICSI. Problemy reproduktsii. 2015;2:8-13. (In Russ.). doi: 10.17116/repro20152128-13
  13. Burlev VA, Ilyasova NA. AlphaB-crystallin expression in eutopic and ectopic endometrium among the patients with peritoneal form endometriosis: pregnancy outcome. Problemy reproduktsii. 2016;22(1):12-19. (In Russ.). doi: 10.17116/repro201622112-19
  14. Burlev VA, Ilyasova NA. Particular signaling LIF/LIFE/gp130/SOCS1 pathway in patients with peritoneal endometriosis and infertility. Problemy reproduktsii. 2016;22(2):24-32. (In Russ.). doi: 10.17116/repro201622224-32
  15. Burlev VA, Ilyasova NA, Shishkanova OA. Ciklicheskij angiogenez jeutopicheskogo jendometrija. Problemy reproduktsii. 2006;6:22-30. (In Russ.). Available at: http://www.fesmu.ru/elib/Article.aspx?id=157767 Accessed June 27,2016
  16. Baston-Buest DM, Porn AC, Schanz A, et al. Expression of VEGF receptor neuropilin-1 at the human embryo-maternal interface. Eur J Obstet Gynecol Reprod Biol. 2011;154:151-156. doi: 10.1016/j.ejogrb.2010.10.018
  17. Barut F, Barut A, Gun BD, et al. Intrauterine growth restriction and placental angiogenesis. Diagn Pathol. 2010;5:24-30. doi: 10.1186/1746-1596-5-24
  18. Bernabeu C, Conley BA, Vary CP. Novel biochemical pathways of endoglin in vascular cell physiology. J Cell Biochem. 2007;102:1375-1388. doi: 10.1002/jcb.21594
  19. Carmeliet P. Angiogenesis in health and disease. Nat Med. 2003;9:653-660. doi: 10.1038/nm0603-653
  20. Clark DE, Smith SK, Sharkey AM, et al. Localization of VEGF and expression of its receptors flt and KDR in human placenta throughout pregnancy. Hum Reprod. 1996;11:1090-1098. doi: 10.1093/oxfordjournals.humrep.a019303
  21. Charnock JDS. Soluble flt 1 and the angiopoietins in the development and regulation of placental vasculature. J Anat. 2002;200(6):607-615. doi: 10.1046/j.1469-7580.2002.00063.x
  22. D'Andrea LD, Romanelli A, Di Stasi R, et al. Bioinorganic aspects of angiogenesis. Dalton Trans. 2010;39:7625-7636. doi: 10.1039/c002439b. Epub 2010 Jun 10
  23. Demir R, Seval Y, Huppertz B. Vasculogenesis and angiogenesis in the early human placenta. Acta Histochem. 2007;109:257-265. doi: 10.1016/j.acthis.2007.02.008
  24. Demir R, Yaba A, Huppertz B. Vasculogenesis and angiogenesis in the endometrium during menstrual cycle and implantation. Acta Histochem. 2010;112:203-214. doi: 10.1016/j.acthis.2009.04.004
  25. Dimberg A, Rylova S, Dieterich LC, Olsson AK, Schiller P, Wikner C, Bohman S, Botling J, Lukinius A, Wawrousek EF, et al. alphaB-crystallin promotes tumor angiogenesis by increasing vascular survival during tube morphogenesis. Blood. 2008;111:2015-2023. doi: 10.1182/blood-2007-04-087841
  26. Ferrara N. Vascular endothelial growth factor. Arterioscler Thromb Vasc Biol. 2009;29:789-791. doi: 10.1161/ATVBAHA.108.179663
  27. Gourvas V, Dalpa E, Konstantinidou A, et al. Angiogenic factors in placentas from pregnancies complicated by fetal growth restriction (review). Mol Med Report. 2012;6:23-27. doi: 10.3892/mmr.2012.898
  28. Govinden R, Bhoola KD. Genealogy, expression, and cellular function of transforming growth factor beta. Pharmacol Ther. 2003;98;257-265. doi: 10.1016/S0163-7258(03)00035-4
  29. Harris LK. Review: Trophoblast-vascular cell interactions in early pregnancy: how to remodel a vessel. Placenta. 2010;31:93-98. doi: 10.1016/j.placenta.2009.12.012
  30. Hess AP, Hirchenhain J, Schanz A, et al. Angiopoietin-1 and Ang-2 mRNA and protein expression in mouse preimplantation embryos and uteri suggests a role in angiogenesis during implantation. Reprod Fertil Dev. 2006;18:509-516. doi: 10.1071/RD05110
  31. Jauniaux E. Design, beauty and differentiation: the human fetus during the first trimester of gestation. Reprod Biomed Online. 2000;1:107-108. doi: 10.1016/S1472-6483(10)61948-7
  32. Jauniaux E, Watson AL, Hempstock J, et al. Onset of maternal arterial blood flow and placental oxidative stress. A possible factor in human early pregnancy failure. Am J Pathol. 2000;157:2111-2122. doi: 10.1016/S0002-9440(10)64849-3
  33. Jones RL, Stoikos C, Findlay JK, et al. TGF-beta superfamily expression and actions in the endometrium and placenta. Reproduction. 2006;132:217-232. doi: 10.1530/rep.1.01076
  34. Kaluz S, Kaluzová M, Stanbridge EJ. Regulation of gene expression by hypoxia: integration of the HIF transduced hypoxic signal at the hypoxia responsive element. Clin Chim Acta. 2008;395:6-13. doi: 10.1016/j.cca.2008.05.002
  35. Khankin EV, Royle C, Karumanchi SA. Placental vasculature in health and disease. Semin Thromb Hemost. 2010;36:309-320. doi: 10.1055/s-0030-1253453
  36. Lafontaine L, Chaudhry P, Lafleur MJ, et al. Transforming growth factor-β regulates proliferation and invasion of rat placental cell lines. Biol Reprod. 2011;84:553-559. doi: 10.1095/biolreprod.110.086348
  37. Lala PK, Nandi P. Mechanisms of trophoblast migration, endometrial angiogenesis in preeclampsia: The role of decorin. Cell Addh Migr. 2016 Mar 3;10(1-2):111-125. doi: 10.1080/19336918.2015.1106669
  38. Levine RJ, Lam C, Qian C, et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med. 2006;355:992-1005. doi: 10.1056/NEJMoa055352
  39. Maglione D, Guerriero V, Viglietto G, et al. Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc Natl Acad Sci USA. 1991;88(20):9267-9271. doi: 10.1073/pnas.88.20.9267
  40. Mano Y, Kotani T, Shibata K, et al. The loss of endoglin promotes the invasion of extravillous trophoblasts. Endocrinology. 2011;152:4386-4394. doi: 10.1210/en.2011-1088
  41. Mihu CM, Suşman S, Rus Ciucă D, et al. Aspects of placental morphogenesis and angiogenesis. Rom J Morphol Embryol. 2009;50:549-557. Available at: http://www.rjme.ro/RJME/resources/files/500409549557.pdf Accessed June 27,2016
  42. Pepper MS. Transforming growth factor beta: vasculogenesis, angiogenesis, and vessel wall integrity. Cytokine Growth Factor Rev. 1997;8:21-43. doi: 10.1016/S1359-6101(96)00048-2
  43. Pijnenborg R, Vercruysse L, Hanssens M. The uterine spiral arteries in human pregnancy: facts and controversies. Placenta. 2006;27:939-958. doi: 10.1016/j.placenta.2005.12.006
  44. Plaisier M. Decidualisation and angiogenesis. Best Pract Res Clin Obstet Gynaecol. 2011;25:259-271. doi: 10.1016/j.bpobgyn.2010.10.011
  45. Plaisier M, Rodrigues S, Willems F, et al. Different degree of vascularisation and their relationship to the expression of vascular endothelial growth factor, placental growth factor, angiopoietins, and their receptors in first-trimester decidual tissues. Fertil Steril. 2007;88(1):176-187. doi: 10.1016/j.fertnstert.2006.11.102
  46. Ribatti D, Conconi MT, Nussdorfer GG. Nonclassic endogenous novel regulators of angiogenesis. Pharmacol Rev. 2007;59:185-205. doi: 10.1124/pr.59.2.3
  47. Salafia CM, Pezzullo JC, López-Zeno JA, et al. Placental pathologic features of preterm preeclampsia. Am J Obstet Gynecol. 1995;173:1097-1105. doi: 10.1016/0002-9378(95)91333-5
  48. Schiessl B, Innes BA, Bulmer JN, et al. Localization of angiogenic growth factors and their receptors in the human placental bed throughout normal human pregnancy. Placenta. 2009;30:79-87. doi: 10.1016/j.placenta.2008.10.004
  49. Schuhmann RA. Placentone structure of the human placenta. Bibl Anat. 1982;22:46-57. Available at: http://www.ncbi.nlm.nih.gov/pubmed/7126152 Accessed June 27,2016
  50. Seval Y, Korgun ET, Demir R. Hofbauer cells in early human placenta: possible implications in vasculogenesis and angiogenesis. Placenta. 2007;28:841-845. doi: 10.1016/j.placenta.2007.01.010
  51. Shalaby F, Rossant J, Yamaguchi TP, et al. Failure of blood island formation and vasculogenesis in Flk 1 deficient mice. Nature.1995;376(6535):62-66. doi: 10.1038/376062a0
  52. Singh M, Kindelberger D, Nagymanyoki Z, et al. Vascular endothelial growth factors and their receptors and regulators in gestational trophoblastic diseases and normal placenta. J Reprod Med. 2012;57:197-203. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22696812?dopt=Abstract Accessed June 27,2016
  53. Torry DS, Leavenworth J, Chang M, et al. Angiogenesis in implantation. J Assist Reprod Genet. 2007;24:303-315. doi: 10.1007/s10815-007-9152-7
  54. Vuorela P, Carpén O, Tulppala M. VEGF, its receptors and the tie receptors in recurrent miscarriage. Mol Hum Reprod. 2000;6:276-282. doi: 10.1093/molehr/6.3.276
  55. Whitley GS, Cartwright JE. Trophoblast-mediated spiral artery remodelling: a role for apoptosis. J Anat. 2009;215:21-26. doi: 10.1111/j.1469-7580.2008.01039.x
  56. Zhong W, Wang QT, Sun T, et al. FGF ligand family mRNA expression profile for mouse preimplantation embryos, early gestation human placenta, and mouse trophoblast stem cells. Mol Reprod Dev. 2006;73:540-550. doi: 10.1002/mrd.20417
  57. Zygmund M, Herr F, Münstedt K, et al. Angiogenesis and vasculogenesis in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2003;110:10-18. doi: 10.1016/S0301-2115(03)00168-4
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