Objective. To evaluate the effectiveness of the combined treatment of infertility in women with endometriosis with the use of progestogen (dienogest) and an agonist of gonadotropin-releasing hormone(aGnRH). Material and methods. The design was a prospective randomized study. The study included 62 patients with histologically verified endometriosis and infertility. Exclusion criteria were: age younger than 18 and older than 45 years, male factor of infertility, chronic anovulation, blocked tubes, severe extragenital diseases. 42 patients after surgical treatment has been administered aGnRH buserelin 3.75 mg or 3.75 mg Diferelin IM every 28 days for 3 months. 20 women has been administered dienogest at a dose of 2 mg per day for 6 months. Results. Combined treatment of infertility in patients with endometriosis with surgical method (coagulation and excision), followed by the use of aGnRH or dienogest is effective in 1/3 patients. The efficacy of treatment is not dependent on the variant of medical therapy. However, patients receiving aGnRH more likely had a miscarriage. The effectiveness of aGnRH and dienogest to endometriosis pain treatment was high in both groups, but the incidence and severity of adverse events was more significant in patients receiving aGnRH. Conclusion. The effectiveness of аGnRH and dienogest in infertile patients with endometriosis in the treatment of infertility and pain relief were similar. The frequency of side effects and miscarriageis was higher in patients who received GnRHa.