Objective. To define the efficacy of complex evaluation of endometrium (adequacy of endometrial wavelike activity and perfusion) for prognosis of successful implantation at in vitro fertilization (IVF) cycles. Material and methods. Comparative retrospective analysis of 101 IVF cycles. Inclusion criteria: age younger than 41, good quality of embryos. Exclusion criteria: age older than 41, poor quality of embryos, presence of fibroids of large size, hydrosalpinx, the presence of endometrial pathology, severe extragenital disorders. Embryo transfer (ET) was carried out during ovarian stimulation (if low risk of ovarian hyper stimulation syndrome), also at frozen-thawed ET cycles. The patients were divided into two groups: 1st group (n=38) - the cases of adequate endometrial wavelike activity, 2nd group (n=63) - the cases of absence of endometrial wavelike activity. Results. Significant differences of endometrial wavelike activity depending on the main reason of infertility were fixed in groups. Absence of adequate endometrial wavelike activity during the «implantation window» was associated with presence of chronic endometritis (85.7% vs. 28.9%; p<0.05), tubal factor of infertility (50.8% vs. 23.7%; p<0.05), adenomyosis (50.8% vs. 23.7%; p<0.05) thin endometrium (61.9% vs. 15.9%; p<0.05). Adequate endometrial blood flow was registered significantly more often in the 1st group (73.7% vs. 20.6%; p<0.05). The pregnancy rates were also significantly higher in the 1st group (63.1% vs. 39.7%; p<0.05). Conclusion. The combination of features: presence of adequate endometrial wavelike activity and blood flow during the «implantation window» is a strong predictor of successful implantation at IVF cycles.