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Kokoeva F.B.

Kafedra akusherstva i ginekologii stomatologicheskogo fakul'teta Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta im. A.I. Evdokimova Minzdrava Rossii

Tsakhilova S.G.

Department of Obstetrics and Gynecology, Faculty of Dentistry, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

Nikulin B.A.

Moscow State University of Medicine and Dentistry Department of obstetrics and gynecology. Moscow, Russia, 127473

Sarakhova D.Kh.

Kafedra akusherstva i ginekologii stomatologicheskogo fakul'teta Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta Minzdravsotsrazvitiia Rossii

Dzansolova A.V.

Department of obstetrics and Gynecology, Stomatologic Faculty, Moscow State University of Medicine and Dentistry named after A.I. Evdokomov, Russian Federation, Moscow, Delegatskaya street, 20/1, 127473

Kravtsova M.E.

Department of obstetrics and Gynecology, Stomatologic Faculty, Moscow State University of Medicine and Dentistry named after A.I. Evdokomov, Russian Federation, Moscow, Delegatskaya street, 20/1, 127473

Phagocytes oxidative metabolism and antioxidative activity in patients with preeclampsia

Authors:

Kokoeva F.B., Tsakhilova S.G., Nikulin B.A., Sarakhova D.Kh., Dzansolova A.V., Kravtsova M.E.

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Journal: Russian Journal of Human Reproduction. 2015;21(5): 17‑22

DOI: 10.17116/repro201521517-22

Views: 820

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Table of contents

PHAGOCYTES OXIDATIVE METABOLISM AND ANTIOXIDATIVE ACTIVITY IN PATIENTS WITH PREECLAMPSIA
PHAGOCYTES OXIDATIVE METABOLISM AND ANTIOXIDATIVE ACTIVITY IN PATIENTS WITH PREECLAMPSIA

To cite this article:

Kokoeva FB, Tsakhilova SG, Nikulin BA, Sarakhova DKh, Dzansolova AV, Kravtsova ME. Phagocytes oxidative metabolism and antioxidative activity in patients with preeclampsia. Russian Journal of Human Reproduction. 2015;21(5):17‑22. (In Russ.)
https://doi.org/10.17116/repro201521517-22

Подписка 2025-2 (Russian Journal of Human Reproduction)
 
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Objective — to improve the treatment and to create the prevention and to determine prognostic risk criteria in pregnant women with preeclampsia by comparing oxidative metabolism of blood phagocytes, lipid peroxidation and endointoxication. Material and methods. The study enrolled 100 pregnant women at the age of 17 to 40 years. Study groups consisted of 78 patients with preeclampsia (case group) and 22 healthy normotensive pregnant women (control group). Results. The study showed correlation between blood phagocytes oxidative metabolism, antioxidative system changes and severity of preeclampsia. Increased serum levels of superoxide anion more than 210 nM/l could be suggested as prognostic index of preeclampsia. Conclusion. Preeclampsia is characterized by oxidative stress, increased phagocyte production of superoxide anion coupled with deficiency of superoxide dismutase. Our study suggests that oxidative stress is an important factor in the pathogenesis of preeclampsia.

Keywords:

preeclampsia
superoxide anion phagocyte production
oxidative stress
endointoxication

Authors:

Kokoeva F.B.

Kafedra akusherstva i ginekologii stomatologicheskogo fakul'teta Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta im. A.I. Evdokimova Minzdrava Rossii

Tsakhilova S.G.

Department of Obstetrics and Gynecology, Faculty of Dentistry, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

Nikulin B.A.

Moscow State University of Medicine and Dentistry Department of obstetrics and gynecology. Moscow, Russia, 127473

Sarakhova D.Kh.

Kafedra akusherstva i ginekologii stomatologicheskogo fakul'teta Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta Minzdravsotsrazvitiia Rossii

Dzansolova A.V.

Department of obstetrics and Gynecology, Stomatologic Faculty, Moscow State University of Medicine and Dentistry named after A.I. Evdokomov, Russian Federation, Moscow, Delegatskaya street, 20/1, 127473

Kravtsova M.E.

Department of obstetrics and Gynecology, Stomatologic Faculty, Moscow State University of Medicine and Dentistry named after A.I. Evdokomov, Russian Federation, Moscow, Delegatskaya street, 20/1, 127473

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