Objective. To study the isolated blood flow disorders in the pool of uterine arteries in the low-risk pregnancy after 18-week gestation and to detect the connection between blood flow disorders and infection processes. Material and methods. Doppler screening as well as analysis of spectrograms of uteroplacental and fetal blood flow of 357 pregnant women was performed. Results. Low-risk pregnancy was accompanied by high hemodynamic disorders rate (14%) in the system of mother—placenta—fetus. The reduced perfusion of utero-placental blood flow (67.9%) with mainly one-side disorders were most common. High correlation between utero-placental blood flow reduction and extragenital chronic infection was revealed. The treatment improved the hemodynamics in idiopathic forms of uteroplacental perfusion disorders. The method of choice is dipiridamol (75 mg daily). Conclusion. Isolated one-side disorders of uteroplacental blood flow in low-risk pregnancy may be considered as the sign of chronic infection. Proper diagnostics and treatment allow to avoid the hemodynamic disorders progression.