Objective. To analyse the morphofunctional state of Leydig cells of adult posterity from female rats with experimental chronic liver injury of various genesis. Material and methods. Sexually mature (70-day) posterity of female rats with experimental injury of the hepatobiliary system of various genesis were investigated. Results. Immobilization stress causes a significant decrease in sperm concentration. Conclusion. Female rats with experimental liver injury of various genesis in conditions of immobilization stress born the posterity with low antistress resistance of Leydig cells leading to the reduction in the total amount of interstitial endocrine cells and their active fractions. The effect of immobilization stress in intact animals , by contrast, caused an increase in the number of active Leydig cells in the posterity's gonads.