Objective - to define the most significant factors and mechanisms of selectin system in embryo implantation. Material and methods. PubMed database was searched using relevant keywords to identify studies that reported on selectins and pregnancy outcomes after IVF. Results. The entry criteria were fulfilled by 467 studies, 27 of them showed statistically significant differences in results (p<0.001). The analysis of L-selectin level in cultural medium can improve embryo selection for transfer and increase the efficiency of IVF program. L-selectin level >1710 ng/ml in blood in time of "implantation window" demands additional analysis of endometrium and treatment. Conclusion. High L-selectin expression in stromal cells and a low expression МЕCА-79 in superficial epithelium and glands requires preliminary preparation of endometrium before IVF program.