Objective. To assess the features of formation of the "syndrome after artificial menopause" depending on the extent of surgery and to develop an algorithm of examination and treatment of these women. Мaterial and methods. Carbohydrate and lipid metabolism, hormonal profile, blood cytochemical profile and indicators of daily monitoring HELL were investigated in 138 women after hysterectomy (group 1) and 130 women after hysterectomy with unilateral adnexectomy (group 2). The control group included 40 patients with small asymptomatic uterine fibroid. Results. The study showed a rapid progression of metabolic disorders, arterial hypertension with duration of hysterectomy. The performed research showed no hypoestrogenemia after hysterectomy with preservation of ovarian tissue in women of reproductive age. Increased concentrations of serotonin and histamine was revealed. The functional activity of mitochondria showed that 33% of women had altered enzymatic status of leukocytes with increased mitochondria activity. Conclusions. The revealed disorders may indicate the hypothalamic and medulla oblongata dysfunction, manifested with eating disorders and altered vegetative regulation of cardiovascular system. The mitochondrial dysfunction can play role in the pathogenesis of the "syndrome after artificial menopause".