The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Samulyzhko V.S.

FGBU "NII akusherstva i ginekologii im. D.O. Otta" SZO RAMN, Sankt-Peterburg

Kogan I.Iu.

FGBU "NII akusherstva i ginekologii im. D.O. Otta" SZO RAMN, Sankt-Peterburg

Empty follicle syndrome in assisted reproductive technology programs (a review)

Authors:

Samulyzhko V.S., Kogan I.Iu.

More about the authors

Read: 3598 times


To cite this article:

Samulyzhko VS, Kogan IIu. Empty follicle syndrome in assisted reproductive technology programs (a review). Russian Journal of Human Reproduction. 2013;(2):65‑69. (In Russ.)

Recommended articles:
The Pate­rnity Test. Russian Journal of Human Reproduction. 2025;(4):41-45
The role of pelvic inflammatory diseases in reproductive function diso­rders in women. Russian Bulletin of Obstetrician-Gynecologist. 2025;(2):48-54

References:

  1. Lok F., Pritchard J., Lashen H. Successful treatment of empty follicle syndrome by triggering endogenous LH surge using GnRH agonist in an antagonist down-regulated IVF cycle. Hum Reprod 2003; 18: 10: 2079-2081.
  2. Coulam C.B., Bustillo M., Schulman J.D. Empty follicle syndrome. Fertil Steril 1986; 46: 6: 1153-1155.
  3. Sagamonova K.Yu., Palieva N.V., Kazantseva T.A. Puti optimizatsii programm EKO u patsientok s sindromom "pustykh" follikulov. Sb. mater. XVI mezhdunarodnoi konferentsii RARCh "Vspomogatel'nye reproduktivnye tekhnologii segodnya i zavtra". Rostov-na-Donu 2007; 23-26.
  4. Reichman D.E., Greenwood E., Meyer L. et al. Can in vitro fertilization cycles be salvaged by repeat administration of intramuscular human chorionic gonadotropin the day after failed. Fertil Steril 2012; 98: 3: 671-674.
  5. Baum M., Machtinger R., Yeruchalmi G.M. et al. Recurrence of empty follicles syndrome with stimulated IVF cycles. Gynecol Endocrinol 2012; 28: 4: 293-295.
  6. Ng S.P., Jamil M.A., Nurshaireen A. et al. The empty follicles syndrome. Med J Malaysia 2006; 61: 4: 499-500.
  7. Mesen T.B., Yu B., Richter K.S. et al. The prevalence of genuine empty follicles syndrome. Fertil Steril 2011; 96: 6: 1375-1377.
  8. Bustillo M. Unsuccessfuloocyte retrieval: technical artefact or genuine 'empty follicles syndrome'? Reprod Biomed Online 2004; 8: 1: 59-67.
  9. van Heusden A.M., van Santbrink E.J., Schipper I. et al. The empty follicle syndrome is dead. Fertil Steril 2008; 89: 3: 746.
  10. Rybalka A.N., Baskakov P.N., Yakovenko S.A. i dr. Sindrom "pustykh" follikulov. Tavricheskii mediko-biol vestn 2012; 15: 2: 244-246.
  11. Awonuga A., Govindbhai J., Zierke S. et al. Continuing the debate on empty follicles syndrome: can it be associated with normal bioavailability of beta-human chorionic gonadotrophin on the day of oocyte recovery. Hum Reprod 1998; 13: 5: 1281-1284.
  12. Quintans C.J., Donaldson M.J., Blanco L.A. et al. Empty follicle syndrome due to human errors: its occurrence in an in-vitro fertilization programme. Hum Reprod 1998; 13: 10: 2703-2705.
  13. Beck-Fruchter R., Weiss A., Lavee M. et al. Empty follicles syndrome: successful treatment in a recurrent case and review of the literature. Hum Reprod 2012; 27: 5: 1357-1367.
  14. Ben-Shlomo I., Schiff E., Levran D. et al. Failure of oocyte retrieval during in vitro fertilization: a sporadic event rather than a syndrome. Fertil Steril 1991; 55: 2: 324-327.
  15. Doyle J.O., Attaman J.A., Styer A.K. et al. Rescue human chorionic gonadotropin for false empty follicle syndrome: optimism for successful pregnancy outcome. Fertil Steril 2012; 98: 2: 450-452.
  16. Zegers-Hochschild F., Fernández E., Mackenna A. et al. The empty follicles syndrome: a pharmaceutical industry syndrome. Hum Reprod 1995; 10: 9: 2262-2265.
  17. Onalan G., Pabuçcu R., Onalan R. et al. Empty follicles syndrome in two sisters with three cycles: case report. Hum Reprod 2003; 18: 9: 1864-1867.
  18. Zreik T.G., Garcia-Velasco J.A., Vergara T.M. et al. Empty follicles syndrome: evidence for recurrence. Hum Reprod 2000; 15: 5: 999-1002.
  19. Desai N., Austin C., AbdelHafez F. et al. Evidence of 'genuine empty follicles' in follicular aspirate: a case report. Hum Reprod 2009; 24: 5: 1171-1175.
  20. Yariz K.O., Walsh T., Uzak A. et al. Inheritedmutation of the luteinizing hormone/choriogonadotropin receptor (LHCGR) in empty follicle syndrome. Fertil Steril 2011; 96: 2: 125-130.
  21. Krishna D., Rajashekar L., Patil M. Empty follicle syndrome-Still an enigma. J Hum Reprod Sci 2008; 1: 2: 86-89.
  22. Meniru G.I., Craft I.L. Evidence from a salvaged treatment cycle supports an aetiology for the empty follicle syndrome that is related to terminal follicular developmental events. Hum Reprod 1997; 12: 11: 2385-2387.
  23. Vujisic S., Stipoljev F., Bauman R. et al. Pericentric inversion of chromosome 2 in a patient with the empty follicle syndrome: case report. Hum Reprod 2005; 20: 9: 2552-2555.
  24. Laufer N., DeCherney A.H., Tarlatzis B.C. et al. Delaying human chorionic gonadotropin administration in human menopausal gonadotropin-induced cycles decreases successful in vitro fertilization of human oocytes. Fertil Steril 1984; 42: 2: 198-203.
  25. Hassan H.A., Saleh H.A., Khalil O. et al. Double oocyte aspiration may be a solution for empty follicle syndrome: case report. Fertil Steril 1998; 69: 1: 138-139.
  26. Snaifer E., Hugues J.N., Poncelet C. et al. 'Empty follicle syndrome' after human errow: pregnancy obtained after repeated oocyte retrieval in a gonadotropin-releasing hormone antagonist cycle. Fertil Steril 2008; 90: 3: 850: e13-e15.
  27. Duru N.K., Cincik M., Dede M. et al. Retrieval of zona-free immature oocytes in a woman with recurrent empty follicle syndrome: a case report. J Reprod Med 2007; 52: 9: 858-863.
  28. Inan M.S., Al-Hassan S., Ozand P. et al. Transcriptional profiling of granulosa cells from a patient with recurrent empty follicle syndrome. Reprod Biomed Online 2006; 13: 4: 481-491.
  29. Uygur D., Alkan R.N., Batuoğlu S. Recurrent empty follicle syndrome. J Ass Reprod Genet 2003; 20: 9: 390-392.
  30. Rowland G.F., Forsey T., Moss T.R. et al. Failure of in vitro fertilization and embryo replacement following infection with Chlamydia trachomatis. J In vitro Fertil Embryo Transf 1985; 2: 3: 151-155.
  31. Smisha M.P., Sankar K., Thomas B. et al. Recurrent genuine empty follicle syndrome. J Hum Reprod Sci 2011; 4: 3: 147-149.
  32. Vutyavanich T., Piromlertamorn W., Ellis J. Immature Oocytes in "Apparent Empty Follicle Syndrome": a Case Report. Case Report Med 2010; 367-505.
  33. Stevenson T.L., Lashen H. Empty follicle syndrome: the reality of a controversial syndrome, a systematic review. Fertil Steril 2008; 90: 3: 691-698.
  34. Asch R.H., Li H.P., Yovich J.L. et al. Failed oocyte retrieval after lack of human chorionic gonadotropin administration in assisted reproductive technology. Fertil Steril 1992; 58: 2: 361-365.
  35. Khalaf Y., Braude P. 'Curing' empty follicle syndrome. Hum Reprod 1997; 12: 7: 1601.
  36. Yu B., Richter K.S., Widra E.A. et al. The incidence of genuine empty follicle syndrome. Fertil Steril 2010; 94: 95.
  37. Klepikova A.A., Sagamonova K.Yu., Palieva N.V. i dr. Kriterii fertil'nosti patsientok s sindromom "pustykh" follikulov v programmakh vspomogatel'nykh reproduktivnykh tekhnologii. Ross vestn akush-gin 2008; 8: 3: 25-28.
  38. Nikolettos N., Asimakopoulos B., Simopoulou M. et al. A borderline form of empty follicle syndrome. Case report. Clin Exp Obstet Gynecol 2004; 31: 7: 79-80.
  39. Hourvitz A., Maman E., Brengauz M. et al. In vitro maturation for patients with repeated in vitro fertilization failure due to "oocyte maturation abnormalities". Fertil Steril 2010; 94: 2: 496-501.
  40. Lorusso F., Depalo R., Tsadilas S. et al. Is the occurrence of the empty follicle syndrome a predictor that a subsequent stimulated cycle will be an unfavourable one. Reprod Biomed Online 2005; 10: 5: 571-574.
  41. Rosen M.P., Shen S., Dobson A.T. et al. A quantitative assessment of folliclesize on oocyte developmental competence. Fertil Steril 2008; 90: 3: 684-690.
  42. Rosen M.P., Zamah A.M., Shen S. et al. The effect of follicular fluid hormones on oocyte recovery after ovarian stimulation: FSH level predicts oocyte recovery. Reprod Biol Endocrinol 2009; 7: published online.
  43. Harrison R.F., Fawzy M. Empty follicle syndrome. Hum Reprod 1996; 11: 2: 459-460.
  44. Stefunidis K., Grammatis M.,Pappas K. et al. Empty follicle syndrome associated with ovarian torsion in an in vitro fertilization program. JSLS 2002; 6: 3: 215-216.
  45. Ndukwe G., Thornton S., Fishel S. et al. 'Curing' empty follicle syndrome. Hum Reprod 1997; 12: 1: 21-23.
  46. Esposito M.A., Patrizio P. Partial follicular aspiration for salvaging an IVF cycle after improper hCG administration. A case report. J Reprod Med 2000; 45: 6: 511-514.
  47. Kourtis A., Rousso D., Panidis D. The empty follicle syndrome. J Endocrinol Invest 2004; 27: 2: 187-191.
  48. Hirshfeld-Cytron J.,Kim H.H. Empty follicle syndrome in the setting of dramatic weight loss after bariatric surgery: case report and review of available literature. Fertil Steril 2008; 90: 4: 1199: e21-e23.
  49. Qublan H., Tahat Y., Al-Masri A. Primary ovarian pregnancy after the empty follicle syndrome: a case report. J Obstet Gynaecol Res 2008; 34: 3: 422-444.
  50. Mulders A.G., Laven J.S., Imani B. et al. IVF outcome in anovulatory infertility (WHO group 2)-including polycystic ovary syndrome--following previous unsuccessful ovulation induction. Reprod Biomed Online 2003; 7: 1: 50-58.
  51. Coskun S., Madan S., Bukhari I. et al. Poor prognosis in cycles following "genuine" empty follicle syndrome. Eur J Obstet Gynecol Reprod Biol 2010; 150: 2: 157-159.
  52. Reichman D.E., Hornstein M.D., Jackson K.V. et al. Empty follicle syndrome - does repeat administration of hCG really work. Fertil Steril 2010; 94: 1: 375-377.
  53. Head J.G., Giannios N.M., Weil S.J. et al. Measuring serum hCG levels between hCG injection and egg retrieval is an effective approach to avoiding 'empty follicle syndrome'. Fertil Steril 2008; 90: 232.
  54. Aktas M., Beckers N.G., van Inzen W.G. et al. Oocytes in the empty follicle: a controversial syndrome. Fertil Steril 2005; 84: 6: 1643-1648.
  55. Peñarrubia J., Balasch J., Fábregues F. et al. Recurrent empty follicle syndrome successfully treated with recombinant HCG. Hum Reprod 1999; 14: 1703-1706.
  56. Evbuomwan I.O., Fenwick J.D., Shiels R. et al. Severe ovarian hyperstimulation syndrome following salvage of empty follicle syndrome. Hum Reprod 1999; 14: 7: 1707-1709.
  57. Sahebkashaf H., Moghadam R., Sahand M. et al. 6 hours more exposure of Β-HCG may salvage the majority of ART empty follicle syndrome (EFS) cycles. Fertil Steril 2004; 82: 229.
  58. Doyle J.O., Attaman J.A., Styer A.K. et al. Rescue human chorionic gonadotropin for false empty follicle syndrome: optimism for successful pregnancy outcome. Fertil Steril 2012; 98: 450-452.
  59. Ubaldi F., Nagy Z., Janssenwillen C. et al. Ovulation by repeated human chorionic gonadotrophin in 'empty follicle syndrome' yields a twin clinical pregnancy. Hum Reprod 1997; 12: 454-456.
  60. Papier S., Lipowicz R., De Vincentiis S. et al. Pregnancy obtained by the transfer of frozen-thawed embryos originating from a rescued empty follicle syndrome cycle. Fertil Steril 2000; 74: 603-604

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.