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Pluzhnikova T.A.

Tsentr profilaktiki i lecheniia nevynashivaniia beremennosti, rodil'nyĭ dom #1;
NII akusherstva i ginekologii im. D.O. Otta SZO RAMN, Sankt-Peterburg

Komarov E.K.

Tsentr profilaktiki i lecheniia nevynashivaniia beremennosti, rodil'nyĭ dom #1;
NII akusherstva i ginekologii im. D.O. Otta SZO RAMN, Sankt-Peterburg

DIAGNOSIS AND TREATMENT OF CHRONIC ENDOMETRITIS IN WOMEN WITH PREVIOUS MISCARRIAGES

Authors:

Pluzhnikova T.A., Komarov E.K.

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Journal: Russian Journal of Human Reproduction. 2012;(6): 30‑33

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To cite this article:

Pluzhnikova TA, Komarov EK. DIAGNOSIS AND TREATMENT OF CHRONIC ENDOMETRITIS IN WOMEN WITH PREVIOUS MISCARRIAGES. Russian Journal of Human Reproduction. 2012;(6):30‑33. (In Russ.)

 
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159 women with previous miscarriages were investigated and in 105 of them (66%) chronic endometritis was revealed. The immunohistochemical method with monoclonal antibodies to NK cells (CD16+, CD56+), HLA-DR+ and B-lymphocytes (CD20+) was used for diagnosis of chronic endometritis. More than a half of patients had chronic endometritis with autoimmune component (AIC) leading to the increase of antiendometrial antibodies (AEA) concentration in peripheral blood. The patients with chronic endometritis and AIC had significantly delayed secretory transformation of endometrium despite of normal ovarian luteal activity. AEA could have independent influence on hormone-receptor interaction provoking thus morphologic and functional disorders of endometrium. Complex therapy of chronic endometritis led to elimination of AEA and normalization of secretory transformation of endometrium.

Keywords:

miscarriage
chronic endometritis
endometrial antibodies

Authors:

Pluzhnikova T.A.

Tsentr profilaktiki i lecheniia nevynashivaniia beremennosti, rodil'nyĭ dom #1;
NII akusherstva i ginekologii im. D.O. Otta SZO RAMN, Sankt-Peterburg

Komarov E.K.

Tsentr profilaktiki i lecheniia nevynashivaniia beremennosti, rodil'nyĭ dom #1;
NII akusherstva i ginekologii im. D.O. Otta SZO RAMN, Sankt-Peterburg

List of references:

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  2. Komarov E.K., Mikhnina E.A., Khokhlov P.P. Immunologicheskii metod kolichestvennogo opredeleniya antitel k endometrial'nomu antigenu v syvorotke krovi: posobie dlya vrachei. Pod red. E.K. Ailamazyana. SPb 2007.
  3. Manukhin I.B., Zakharova T.P. Kompleksnoe lechenie khronicheskogo endometrita u zhenshchin s privychnym nevynashivaniem beremennosti. Ross vestn akush ginekol 2001; 3: 5: 54-55.
  4. Mikhnina E.A. Morfofunktsional'noe sostoyanie endometriya u zhenshchin s besplodiem i nevynashivaniem beremennosti: Avtoref. dis. … d-ra med. nauk. SPb 2009; 40.
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  7. Elinidi V.N. i dr. Sovremennye vozmozhnosti diagnostiki khronicheskogo endometrita. Zhurn akush i zhen bol 2003; 3: 64-68.
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