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Momot A.P.

Altai Branch of the FSBI «National Research Center for Hematology», Barnaul, Russia

Lydina I.V.

Kraevoe GBU "Kraevaia klinicheskaia bol'nitsa", Barnaul

Borisova O.G.

Kraevoe GBU "Kraevaia klinicheskaia bol'nitsa", Barnaul

Elykomov V.A.

Kraevoe GBU "Kraevaia klinicheskaia bol'nitsa", Barnaul

Tsyvkina L.P.

Altaĭskiĭ filial FGBU "Gematologicheskiĭ nauchnyĭ tsentr" Minzdrava Rossii

IN VITRO FERTILIZATION AND MANAGEMENT OF HAEMOSTASIS DISORDERS

Authors:

Momot A.P., Lydina I.V., Borisova O.G., Elykomov V.A., Tsyvkina L.P.

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Journal: Russian Journal of Human Reproduction. 2012;(6): 47‑55

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IN VITRO FERTILIZATION AND MANAGEMENT OF HAEMOSTASIS DISORDERS
IN VITRO FERTILIZATION AND MANAGEMENT OF HAEMOSTASIS DISORDERS

To cite this article:

Momot AP, Lydina IV, Borisova OG, Elykomov VA, Tsyvkina LP. IN VITRO FERTILIZATION AND MANAGEMENT OF HAEMOSTASIS DISORDERS. Russian Journal of Human Reproduction. 2012;(6):47‑55. (In Russ.)

Подписка 2025-2 (Russian Journal of Human Reproduction)
 
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The association of excess thrombin production and hypofibrinolysis is associated with IVF failures, reducing the chance of pregnancy in 12.1 times. On the basis of selected laboratory parameters three groups of women were formed for therapeutic correction (heparin prophylaxis and/or calf-thigh compression) in the cycles of IVF. The treatment of 98 women with hemostasis disorders resulted in pregnancy rate increase in 4.7 times.

Keywords:

IVF
pregnancy
risk factors
thrombin
hypofibrinolysis
heparin
prophylaxis
calf-thigh compressio

Authors:

Momot A.P.

Altai Branch of the FSBI «National Research Center for Hematology», Barnaul, Russia

Lydina I.V.

Kraevoe GBU "Kraevaia klinicheskaia bol'nitsa", Barnaul

Borisova O.G.

Kraevoe GBU "Kraevaia klinicheskaia bol'nitsa", Barnaul

Elykomov V.A.

Kraevoe GBU "Kraevaia klinicheskaia bol'nitsa", Barnaul

Tsyvkina L.P.

Altaĭskiĭ filial FGBU "Gematologicheskiĭ nauchnyĭ tsentr" Minzdrava Rossii

List of references:

  1. Current Practices and Controversies in Assisted Reproduction. Report of a meeting on "Medical, Ethical and Social Aspects of Assisted Reproduction" held at WHO Headquarters in Geneva, Switzerland, 17-21 September 2001. WHO (Geneva) 2002; 396.
  2. Nyboe Andersen A., Goossens V., Bhattacharya S. and The European IVF-monitoring (EIM) Consortium, for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology and intrauterine inseminations in Europe, 2005: results generated from European registers by ESHRE: ESHRE. The European IVF Monitoring Programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Hum Reprod 2009; 24: 6: 1267-1287.
  3. Christiansen O.B., Nielsen H.S., Kolte A.M. Future directions of failed implantation and recurrent miscarriage research. Reprod Biomedicine Online 2006; 13: 71-83.
  4. Amirova A.A., Nazarenko T.A., Mishieva N.G. Faktory, vliyayushchie na iskhody EKO (obzor literatury). Probl reprod 2010; 1: 68-74.
  5. Vartanyan E.V., Aizikovich I.V., Antonov A.R. Prichiny neudach EKO (obzor literatury). Probl reprod 2010; 3: 57-61.
  6. Okhtyrskaya T.A., Yavorovskaya K.A., Shurshalina A.V. i dr. Implantatsionnye poteri v programmakh EKO: rol' nasledstvennoi i priobretennoi trombofilii (obzor literatury). Probl reprod 2010; 2: 53-57.
  7. Gleicher N., Vidali A., Karande V. The immunological "Wars of the Roses": disagreemants amongst reproductive immunologists. Hum Reprod 2002; 17: 539-542.
  8. American Society for Reproductive Immunology Antiphospholipid Antibody Committee: A rational basis for antiphospholipid antibody testing and selective immunotherapy in assisted reproduction: a rebuttal to the American Society for Reproductive Medicine Practice Committee Opinion. Fertil Steril 2000; 74: 631-634.
  9. American Society of Reproductive Medcine. Birmingham. Alabama. Antiphospholipid Antibodies Do Not Affect IVF Success. Fertil Steril 2008; 90: S172-S173.
  10. Zaynulina M., Mirashvili M. The prevalence of congenital and acquired thrombophilia and hyperhomocysteinemia in women with repeated in vitro fertilization failure. J Thrombos Res 2012; 130: 1: S160.
  11. Khizroeva D., Bitsadze V. Clinical value of thrombophilia diagnostics in women with repeated IVF failure. J Thrombos Res 2012; 130: 1: S160.
  12. Momot A.P., Tsyvkina L.P., Taranenko I.A. i dr. Sovremennye metody raspoznavaniya sostoyaniya tromboticheskoi gotovnosti. Barnaul: Izd-vo Altaiskogo gosudarstvennogo universiteta 2011; 138.
  13. Hemker H.C., Al Dieri R., De Smalt F. et al. Thrombin generation, a function test of the haemostatic-thrombotic system. Thromb Haemost 2006; 96: 5: 553-561.
  14. Hemker H.C., Giesen P., Al Dieri R. et al. Calibrated automated thrombin generation measurement in clotting plasma. Pathophys Haemost Thromb 2003; 33: 4-15.
  15. Westerlund E., Henriksson P., Wallén H. et al. Detection of a procoagulable state during controlled ovarian hyperstimulation for in vitro fertilization with global assays of haemostasis. Thromb Res 2012; 46: 4: 417-425.
  16. Martinez-Zamora M.A., Creus M., Tassies D. et al. Reduced plasma fibrinolytic potential in patients with recurrent implantation failure after IVF and embryo transfer. Hum Reprod 2011; 26: 3: 510-516.
  17. Meltzer M.E., Lisman T., De Groot P.G. et al. Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1. Blood 2010; 116: 113-121.
  18. Zorio E., Gilabert-Estellés J., España F. et al. Fibrinolysis: the key to new pathogenetic mechanisms. Curr Med Chem 2008; 15: 923-929.
  19. Nelson S.M., Greer I.A. The potential role of heparin in assisted conception. Hum Reprod Update 2008; 14: 623-645.
  20. Urman B., Ata B., Yakin K. et al. Luteal phase empirical low molecular weight heparin administration in patients with failed ICSI embryo transfer cycles: a randomized open-labeled pilot trial. Hum Reprod 2009; 24: 7: 1640-1647.
  21. Christen Y., Wutschert R., Weimer D. et al. Effects of intermittent pneumatic compression on venous haemodynamics and fibrinolytie activity. Blood Coagul Fibrinolys 1997; 8: 185-190.
  22. Salzman E.W., McManama G.P., Shapiro A.H. et al. Effect of optimization of hemodynamics on fibrinolytie activity and antithrombotic efficacy of external pneumatic calf compression. Ann Surg 1987; 206: 636-641.
  23. Knight M.T.N., Dawson R. Effect of intermittent compression of the arms on deep venous thrombosis in the legs. Lancet 1976; 2: 1265-1267.
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  25. Rova K., Passmark H., Lindqvist P.G. Venous thromboembolism in relation to in vitro fertilization: an approach to determining the incidence and increase in risk in successful cycles. Fertil Steril 2012; 97: 1: 95-100.
  26. Coulam C.B., Jeyendran D. Trombophilic gene polymorphisms are risk factors for unexplained infertility. Fertil Steril 2009; 91: 4: 1516-1517.

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