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Ivanets T.Iu.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdravsotsrazvitiia Rossii, Moskva

Alekseeva M.L.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdravsotsrazvitiia Rossii, Moskva

Goncharova E.A.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdravsotsrazvitiia Rossii, Moskva

Khodzhaeva Z.S.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdravsotsrazvitiia Rossii, Moskva

Vavina O.V.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdravsotsrazvitiia Rossii, Moskva

The markers of preeclampsia in the first and second trimesters of pregnancy

Authors:

Ivanets T.Iu., Alekseeva M.L., Goncharova E.A., Khodzhaeva Z.S., Vavina O.V.

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Journal: Russian Journal of Human Reproduction. 2012;(3): 83‑87

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To cite this article:

Ivanets TIu, Alekseeva ML, Goncharova EA, Khodzhaeva ZS, Vavina OV. The markers of preeclampsia in the first and second trimesters of pregnancy. Russian Journal of Human Reproduction. 2012;(3):83‑87. (In Russ.)

 
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The reference limits of PlGF and sFlt-1 concentration and their ratio are presented in the patients blood during first and second trimesters of pregnancy. A screening algorithm is presented.

Keywords:

preeclampsia
placental grows factor (PlFG)
soluble fms-like tyrosine kinase-1 (sFlt-1)
calcium
vitamin

Authors:

Ivanets T.Iu.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdravsotsrazvitiia Rossii, Moskva

Alekseeva M.L.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdravsotsrazvitiia Rossii, Moskva

Goncharova E.A.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdravsotsrazvitiia Rossii, Moskva

Khodzhaeva Z.S.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdravsotsrazvitiia Rossii, Moskva

Vavina O.V.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdravsotsrazvitiia Rossii, Moskva

List of references:

  1. Shilin D.E. Primenenie kal'tsiya v pervichnoi profilaktike gestoza. RMZh 2008; 16: 25: 1689-1695.
  2. Shilin D.E., Adamyan L.V., Shilin D.A. i dr. Novoe v profilaktike preeklampsii. V kn.: Novye tekhnologii v diagnostike i lechenii ginekologicheskikh zabolevanii. M 2009; 125-126.
  3. Aroch I., Srebro H., Shpigel N.Y. Serum electrolyte concentrations in bitches with eclampsia. Vet Rec 1999; 145: 318-320.
  4. Chandiramani M., Waugh J., Shennan A. Management of hypertension and pre-eclampsia in pregnancy. Trends Urol Gynaecol Sex Health 2007; 12: 23-28.
  5. Drobatz K.J., Casey K.K. Eclampsia in dogs - 31 cases (1995-1998). JAMA 2000; 217: 216-219.
  6. De Vivo A., Baviera G., Giorano D. et al. Endoglin, PlGF and SFLT-1 as markers for predicting preeclampsia. Acta Obstet Gynecol Scand 2008; 87: 837-842.
  7. Frascetti A.A., Hickman M.A. Perparturient hypocalcaemia in four cats. JAMA 1999; 215: 1127-1129.
  8. Lam C., Lim K.-H., Karumanchi S.A. Circulating angiogenic factors in the pathogenesis and prediction of preeclampsia. Hypertens Res 2005; 46: 1077-1085.
  9. Levine R., Maynard S., Qian C., Lim K., England H. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004; 350: 672-683.
  10. Maynard S., Min J., Merchan J., Lim K. Excess placental soluble fms-like tyrosine kinase-1 (sFlt-1) may contribute to endometrial disfunction, hypertension and proteinuria in preeclampsia. J Clin Invest 2003; 111: 649-658.
  11. Roberts J.M., Cooper D.V. Pathogenesis and genetics of pre-eclampsia. Lancet 2001; 357: 53-56.
  12. Shibata E., Rajakumar A., Roberts R.W. et al. Soluble fms-like tyrosine kinase 1 is increased in preeclampsia but not in normo­tensive pregnancies with small-for-gestational-age neonates: relationship to circulating placental growth factor. J Clin Endocrinol Metab 2005; 90: 4895-4903.
  13. Verlohren S., Galindo A., Schlembach D., Zeisler H., Herraiz J. An automated method for the determination of the sFIT-1/PlGF ratio in the assessment of preeclampsia. Am J Obstet Gynecol 2010; 202: 161-173.
  14. Wallace M.S. Management of parturition and problems of the periparturient period of dogs and cats. Semin Vet Med Surg (Small Anim) 1994; 1: 28-37.
  15. Wang A., Rana S., Karumanchi S.A. Preeclampsia: the role of angiogenic factors inits pathogenesis. Physiology 2009; 24: 147-158.

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