The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Surkova E.V.

FGBU Éndokrinologicheskiĭ nauchnyĭ tsentr MZ RF, Moskva

Biphasic insulin analog NovoMix 30 is a possible solution to overcome key problems of biphasic human insulin therapy for DM type 2 patients

Authors:

Surkova E.V.

More about the authors

Journal: Problems of Endocrinology. 2012;58(4): 58‑62

Read: 694 times

Download PDF (RU)
Contact the author
Table of contents

BIPHASIC INSULIN ANALOG NOVOMIX 30 IS A POSSIBLE SOLUTION TO OVERCOME KEY PROBLEMS OF BIPHASIC HUMAN INSULIN THERAPY FOR DM TYPE 2 PATIENTS
BIPHASIC INSULIN ANALOG NOVOMIX 30 IS A POSSIBLE SOLUTION TO OVERCOME KEY PROBLEMS OF BIPHASIC HUMAN INSULIN THERAPY FOR DM TYPE 2 PATIENTS

To cite this article:

Surkova EV. Biphasic insulin analog NovoMix 30 is a possible solution to overcome key problems of biphasic human insulin therapy for DM type 2 patients. Problems of Endocrinology. 2012;58(4):58‑62. (In Russ.)

МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
The role of quantitative body composition analysis in popu­lation in the asse­ssment and moni­toring of cardiovascular risk meta­bolic factors. Russian Journal of Preventive Medi­cine. 2024;(12):128-134
Restoration of spermatogenesis suppressed by the use of testosterone, antiestrogen therapy in men with type 2 diabetes mellitus. Russian Journal of Human Reproduction. 2024;(6):156-160
Diabetic reti­nopathy and pregnancy. Russian Annals of Ophthalmology. 2024;(6):145-151
Psoriasis: analysis of como­rbid pathology. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(1):16-21
Cognitive functions asse­ssment of elde­rly patients with type 2 diabetes mellitus. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):46-50
A clinical case of diabulimia in type 1 diabetes mellitus: Psychopathological mechanisms and psychosomatic rela­tionships. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):118-123
Features of comprehensive treatment in a patient with complicated type 2 diabetes mellitus: A clinical case. Piro­gov Russian Journal of Surgery. 2025;(6):128-132
Early diagnosis and effe­ctive therapy of diabetic poly­neuropathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):62-68
Hype­rtensive diso­rders of pregnancy as a risk factor for chro­nic non-communicable diseases. Russian Journal of Preventive Medi­cine. 2025;(6):114-119
Cere­brovascular disease in clinical practice. Reso­lution of the Expert Council of the Russian Scientific Medi­cal Society of Therapists. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):105-111
Abstract:

This review discusses publications on the usage of biphasic analogue insulin aspart 30/70 (NovoMix 30) in the treatment of patients with type 2 diabetes mellitus. Data on the clinical and pharmaco-economic advantages of NovoMix 30 versus biphasic human insulin was analyzed. The problems of doctor's clinical inertia and patient's psychological insulin resistance, as well as possible solutions to key problems of insulin therapy with help of biphasic insulin aspart 30/70 were discussed.

Keywords:

diabetes mellitus
biphasic insulin analogs
insulin therapy

Authors:

Surkova E.V.

FGBU Éndokrinologicheskiĭ nauchnyĭ tsentr MZ RF, Moskva

Close metadata

References:

  1. Algoritmy spetsializirovannoi meditsinskoi pomoshchi bol'nym sakharnym diabetom. Pod red. I.I. Dedova, M.V. Shestakovoi, 5-i vyp. M 2011.
  2. Suntsov Yu.I., Bolotskaya L.L., Maslova O.V., Kazakov I.V. Epidemiologiya sakharnogo diabeta i prognoz ego rasprostranennosti v Rossiiskoi Federatsii. Sakharnyi diabet 2011; 1: 15-18.
  3. Shah D.R., Hux J.E., Laupacis A., Zinman B., Walraven C. Clinical Inertia in Response to Inadequate Glycemic Control. Do specialists differ from primary care physicians? Diabet Care 2005; 28: 3: 600-606.
  4. O'Connor P. Commentary - improving diabetes care by combating clinical inertia. Health Serv Res 2005; 40: 6: 1854-1860.
  5. Polonsky W.H., Fisher L., Guzman S., Villa-Caballero L., Edelman S.V. Psychological insulin resistance in patients with type 2 diabetes. Diabet Care 2005; 28: 10: 2543-2545.
  6. Karter A.J., Subramanian U., Saha Ch., Crosson J.G., Parker M.M., Swain B.E., Moffet H.H., Marrero D.G. Barriers to insulin initiation. Diabet Care 2010; 33: 4: 733-735.
  7. Heinemann L. Do insulin-treated diabetic patients use an injection-meal-interval in daily life? Diabet Med 1995; 12: 449-450.
  8. Overmann H., Heinemann L. Injection-meal interval: recommendations of diabetologistsand how patients handle it. Diabet Res Clin Pract 1999; 43: 137-142.
  9. McSorley K.M., Bell P.M., Jacobsen L.V., Kristensen A., Lindholm A. Twice-daily biphasic insulin aspart 30 versus biphasic human insulin 30: a double blind cross-over study in adults with type 2 diabetes mellitus. Clin Ther 2002; 24: 530-539.
  10. McNally P.G., Dean J.D., Morris .D., Wilkinson P.D., Compion G., Heller S.R. Used continuous glucose monitoring to measure the frequency of low glucose values when using biphasic insulin aspart 30 compared with biphasic human insulin 30: a double-blind crossover study in individuals with type 2 diabetes. Diabet Care 2007; 30: 1044-1048.
  11. Rizvi A.A., Lightelm R.J. The use of premixed insulin analogs in the treatment of patients with type 2 diabetes mellitus: advantages and limitations. Insulin 2007; 2: 68-79.
  12. Boehm B.O., Home P.D., Kamp B.N.M., Behrend C., Kamp N.M., Lindhoolm A. Premixed insulin aspart 30 vs. premixed human insulin 30/70 twice daily: a randomized trial in type 1 and type 2 diabetic patients. Diabet Med 2002; 19: 393-399.
  13. Boehm B.O., Vaz J.A., Bronsted L., Home P.D. Long-term efficacy and safety of biphasic insulin aspart in patients with type 2 diabetes. Eur J Inter Med 2004; 15: 496-502.
  14. Heise T., Heinemann L., Hovelmann U., Brauns B., Nosek L., Haahr H.L., Olsen K.J. Biphasic Insulin Aspart 30/70: Pharmacokinetics and Pharmacodynamics Compared With Once-Daily Biphasic Human Insulin and Basal-Bolus Therapy. Diabet Care 2009, 32: 1431-1433.
  15. Shestakova M., Sharma S.K., Almustafa M., Min K.W., Ayad N., Azar S.T., Dansiulesku R., Khutsoan D., Guler S. Transferring type 2 diabetes patients with uncontrolled glycaemia from biphasic human insulin to biphasic insulin aspart 30: experiences from the PRESENT study. Curr Med Res Opin 2007; 23: 12: 3209-3214.
  16. Gao Y., Guo X. Switching from human insulin to biphasic insulin aspart 30 treatment gets more patients with type 2 diabetes to reach target glycosylated hemoglobin <7%: the results from the PRESENT study. Chinese Med J 2010; 123: 9: 1107-1111.
  17. Davidson J.A., Liebl A., Christiansen J.S., Flucher G., Lightelm R.J., Brown D., Gylvin T., Kawamori N. Risk for nocturnal hypoglycemia with biphasic insulin Aspart 30 compared with biphasic human insulin 30 in adults with type 2 diabetes mellitus: a metaanalysis. Clin Ther 2009; 31: 8: 1641-1651.
  18. Morgan C.L., Evans M., Toft A.D., Jankin-Jones S., Pool C.D., Currie C.J. Clinical Effectiveness of Biphasic Insulin Aspart 30:70 Versus Biphasic Human Insulin 30 in UK General Clinical Practice: A Retrospective Database Study. Clin Ther 2011; 33: 27-35.
  19. Velojic-Golubovic M., Mikic D., Pesic M., Dimic D., Radencovic S., Antic S. Biphasic insulin aspart 30: Better glycemic control than with premixed human insulin 30 in obese patients with Type 2 diabetes. J Endocrinol Inv 2009; 32: 23-27.
  20. Ohira M., Endo K., Oyama T., Yamaguchi T., Ban N., Kawana H., Nagayama D., Nagumo A., Saiki A., Murano T., Watanabe H., Miyashita Y., Shirai K. Improvement of postprandial hyperglycemia and arterial stiffness upon switching from premixed human insulin 30/70 to biphasic insulin aspart 30/70. Metabol Clin Experiment 2011; 60: 78-85.
  21. Fakhoury W.K.H., Richter H., Christensen T.E. Real-Life Dosage and Clinical Efficacy of Biphasic Insulin Preparations in Patients With Type 2 Diabetes. Adv Ther 2010; 27: 11: 859-869.
  22. Valentine W.J., Pollock R.F., Plun-Favreau J., White J. Systematic review of the cost-effectiveness of biphasic insulin aspart 30 in type 2 diabetes. Curr Med Res Opin 2010; 26: 6: 1399-1412.
  23. Palmer J.L., Gibbs M., Scheijbeler WKFH, Kotchie R.W., Nielsen S., White J., Valentine W.J. Cost-Effectiveness of Switching to Biphasic Insulin Aspart in Poorly-Controlled Type 2 Diabetes Patients in China. Adv Ther 2008; 25: 8: 752-774.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.